在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse C-C motif chemokine 20 (Ccl20)

Recombinant Mouse C-C motif chemokine 20 (Ccl20)

  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 20(Ccl20)
  • 貨號：
    CSB-YP004784MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 20(Ccl20)
  • 貨號：
    CSB-EP004784MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 20(Ccl20)
  • 貨號：
    CSB-EP004784MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 20(Ccl20)
  • 貨號：
    CSB-BP004784MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse C-C motif chemokine 20(Ccl20)
  • 貨號：
    CSB-MP004784MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Ccl20; Larc; Scya20C-C motif chemokine 20; Beta-chemokine exodus-1; CC chemokine LARC; CC chemokine ST38; Liver and activation-regulated chemokine; Macrophage inflammatory protein 3 alpha; MIP-3-alpha; Small-inducible cytokine A20
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    28-97
  • 氨基酸序列
    ASN YDCCLSYIQT PLPSRAIVGF TRQMADEACD INAIIFHTKK RKSVCADPKQ NWVKRAVNLL SLRVKKM
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a ligand for C-C chemokine receptor CCR6. Signals through binding and activation of CCR6 and induces a strong chemotactic response and mobilization of intracellular calcium ions. The ligand-receptor pair CCL20-CCR6 is responsible for the chemotaxis of dendritic cells (DC), effector/memory T-cells and B-cells and plays an important role at skin and mucosal surfaces under homeostatic and inflammatory conditions, as well as in pathology, including cancer and autoimmune diseases. CCL20 acts as a chemotactic factor that attracts lymphocytes and, slightly, neutrophils, but not monocytes. Involved in the recruitment of both the proinflammatory IL17 producing helper T-cells (Th17) and the regulatory T-cells (Treg) to sites of inflammation. Required for optimal migration of thymic natural regulatory T cells (nTregs) and DN1 early thymocyte progenitor cells. Positively regulates sperm motility and chemotaxis via its binding to CCR6 which triggers Ca2+ mobilization in the sperm which is important for its motility. May be involved in formation and function of the mucosal lymphoid tissues by attracting lymphocytes and dendritic cells towards epithelial cells.
  • 基因功能參考文獻：
    1. Obesity-induced IL-6 shifts macrophage polarization towards tumor-promoting macrophages that produce the CCL-20 in the colitis-associated colorectal cancer (CAC) microenvironment. CCL-20 promotes CAC progression by recruiting CCR6-expressing B-cells and gammadelta T cells via chemotaxis. PMID: 29695802
    2. Blocking or knockdown CCN1 expression ameliorated skin inflammation and reduced the expression of CCL20 in both imiquimod and IL-23-induced psoriasis-like mouse models. PMID: 28602508
    3. these data indicate that CCL20/CCR6 signaling may play an important role in regulating bone mass accrual, potentially by modulating osteoblast maturation, survival, and the recruitment of osteoblast-supporting cells. PMID: 26890063
    4. We crossed Ptf1a(Cre/+) ;Kras(G12D/+) mice with JNK1(-/-) mice to generate Ptf1a(Cre/+) ;Kras(G12D/+) ;JNK1(-/-) (Kras;JNK1(-/-) ) mice. Tumor weight was significantly lower in Kras;JNK1(-/-) mice than in Kras;JNK1(+/-) mice, whereas histopathological features were similar.we concluded that inhibition of activated JNK in pancreatic tumor stroma could be a potential therapeutic target to increase Ccl20 secretion PMID: 28837246
    5. mutually exclusive transcriptional regulation by AP-1 (cjun/cfos) and non-canonical NF-kappaB (RelB/p52) downstream of MEK-ERK and NIK-IKK-alpha-NF-kappaB2 (p100) phosphorylation, respectively was responsible for persistent Ccl20 expression in the colonic cells. PMID: 27590109
    6. Taken together, these data show that, in adipose tissues, IL-17A contributes to exacerbating insulin resistance-enhancing IL-6 production and promotes the infiltration of Th17 cells in cooperation with TNFalpha; these findings represent a novel hypothesis for the association between IL-17A-producing cells and type 2 diabetes. PMID: 27311858
    7. Data (including data from studies in knockout/mutant mice) suggest that expression of Ahr (aryl-hydrocarbon receptor) and its translocation into nucleus are necessary for Ahr ligand-mediated synergistic induction of Ccl20; here, TCDD is Ahr ligand. PMID: 26259605
    8. alpha-hemolytic streptococcus may exacerbate kidney damage in IgA nephropathy through CCL20 response to the effect of Th17 cells. PMID: 25265199
    9. Acquired mtDNA mutations may promote tumorigenic phenotypes through up-regulation of chemokine CCL20. PMID: 25177208
    10. Overexpression of CCL20 in human proximal tubular cells is inhibited by blockade of KCa3.1 under diabetic conditions through inhibition of the NF-kappaB pathway. PMID: 24733189
    11. Our data indicate that estradiol is important in regulating the effects of keratinocyte growth factor on mouse uterine epithelial cell secretion of CCL20 and CXCL1. PMID: 24807244
    12. CCL20 blockage lead to a diminished cerebral immune response in experimental pneumococcal meningitis. PMID: 24699535
    13. This study suggests that CCL20/IL-15 can induce a strong antitumor immune response in tumor tissues and it is a suitable candidate for cancer immunotherapy. PMID: 24657179
    14. Estrogen receptors alpha regulates CCL20/CXCL1 secretion in the female reproductive tract. PMID: 23025258
    15. Cardiac fibroblasts could recruit Th17 cells infiltration into myocardium by secreting CCL20 in acute viral myocarditis. PMID: 24296428
    16. Data indicate that a CCR6/CCL20 chemokine loop instructed rapid increase of B cells in the spleen in response to systemic administration of Nod1 agonists in a TNF-alpha-dependent manner. PMID: 24534531
    17. Neutralization of CCL20 before induction of sepsis increased mortality during sepsis accompanied with increasing epithelial apoptosis in the jejunum and augmenting serum TNF-alpha. PMID: 23601903
    18. CXCR3 promotes recruitment of Th17 cells from the blood into the liver in both human and murine liver injury. Their subsequent positioning near bile ducts is dependent on CCR6 and cholangiocyte-secreted CCL20. PMID: 22796894
    19. Findings suggest that TNF-alpha is essential in the induction of autoimmune hepatitis (AIH) through upregulation of hepatic CCL20 expression, which allows migration of dysregulated splenic T cells. PMID: 23178752
    20. Regulation of CCL20 expression in astrocytes is stimulated by the addition of interleukin (IL)-6, IL-6 soluble receptor, and IL-17. PMID: 22319003
    21. Tumor-associated macrophages recruit CCR6+ regulatory T cells and promote the development of colorectal cancer via enhancing CCL20 production in mice PMID: 21559338
    22. the healing response to corneal epithelial abrasion includes CCL20-dependent influx of CCR6(+) IL-17(+) IL-22(+) gammadelta T cells, and IL-22 contributes to the inflammatory response and promotes epithelial healing PMID: 21518851
    23. IL-9 is produced by several T helper (Th) cell subsets in the presence of IL-4 and induces CCL-20 production by astrocytes to induce the migration of Th17 cells into the central nervous system. PMID: 21346235
    24. Data show that the synergistic actions of pGM-CSF and pMIP3alpha presents a potentially feasible means of controlling immunogenic malignancies and provides a basis for the development of novel immunotherapeutic treatments. PMID: 20804501
    25. CCL20 is important in mediating leukocyte recruitment early upon infection with respiratory syncytial virus. PMID: 20101616
    26. Interfering with CCL20 significantly downregulates the expression of CD4(+)CD25(+) T cell development in mouse thymus. PMID: 18315924
    27. through secretion of CCL20, astrocytes could play an important role in orchestrating the recruitment of specific leukocyte subsets to the inflamed CNS and in regulating CNS-targeted immune responses. PMID: 12528183
    28. In experimental autoimmune encephalitis MIP-3 alpha is required for sensitization of T cells to antigen and for release of T cells from lymph nodes during the course of an immune response. PMID: 12794163
    29. CCL20 plays a vital role in B-cell adhesion to the inflamed endothelium PMID: 12816871
    30. our findings indicate that blockade of MIP-3alpha bioactivity can significantly reduce TNBS-mediated colonic injury and T cell recruitment, suggesting a role for this chemokine in the pathophysiology of intestinal inflammation. PMID: 17272517
    31. CXCL12-CXCR4 and CCL20-CCR6 systems are involved in T lymphocyte-endothelial interaction in microvessels of the small and large intestines. PMID: 17885999
    32. The joint cytokine milieu formed by T cells and synovial cells controls the production of CCL20 and, consequently, the recruitment of chemokine receptor 6 arthritogenic Th cells to the inflamed joints. PMID: 18025126
    33. Our studies suggest that TLR4 expressed by tumor cells may be involved in the induction of chemokines like CCL20. PMID: 18083111
    34. Th17 cytokines stimulate CCL20 production in vitro and in vivo, and thus provide a potential explanation of how CCR6-positive Th17 cells maintain their continual presence in psoriasis through a positive chemotactic feedback loop. PMID: 19295614
    35. Investigated the regulation of ccl20 expression and found different NF-kappaB pathways modulate CCL20 transcription by operating on the same NF-kappaB binding site in the same cell type. PMID: 19303953
    36. the CCR6-CCL20 axis in the choroid plexus controls immune surveillance of the CNS. PMID: 19305396

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Intercrine beta (chemokine CC) family
  • 組織特異性：
    Thymic medulla (at protein level). Prominently expressed in the small intestine, colon and appendix. Also found in thymus, spleen, lymph node and lung. The long form might be dominant in intestinal, and the short form in lymphoid tissues. Expressed by IL1
  • 數據庫鏈接：


主站蜘蛛池模板： 护士张开腿被奷日出白浆| 狠狠色噜噜狠狠狠888米奇视频| 精品国产一区二区三区色欲| 婷婷俺也去俺也去官网| 亚洲国产欧美日韩在线人成| 一二三四在线视频社区3| 老妇肥熟凸凹丰满刺激| 永久免费男同av无码入口| 亚洲成av人影院无码不卡| 巨胸爆乳美女露双奶头挤奶| 久久欧美国产伦子伦精品| 免费视频成人片在线观看| 一区二区三区在线 | 日本| 337p日本欧洲亚洲大胆裸体艺术 | 久久久欧美国产精品人妻噜噜| 国产爆乳无码av在线播放| 国产三级精品三级在线专区| 无套内谢孕妇毛片免费看| 无码人妻久久一区二区三区不卡 | 2021国产精品一卡2卡三卡4卡| 无码中文字幕va精品影院 | 大陆极品少妇内射aaaaaa| 久久久久久久女国产乱让韩| 免费无遮挡很爽很污很黄的网站| 亚洲高清国产拍精品闺蜜合租| 国产精品久线在线观看| 一本久道久久综合狠狠躁av| 秋霞国产精品一区二区| 成年无码av片在线免缓冲| 久久久精品94久久精品| 国产欧美久久一区二区| 国产又色又爽又黄的在线观看视频| 鲁一鲁av2019在线| 亚洲a∨无码男人的天堂| 久久国产avjust麻豆| 欧洲女人性开放免费网站| 女人被爽到呻吟gif动态图视看| 国产区女主播在线观看| 2021久久精品国产99国产精品| 国产aⅴ精品一区二区三区| 波多野结av衣东京热无码专区|