在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Bone morphogenetic protein 10 (Bmp10)

  • 中文名稱:
    Recombinant Mouse Bone morphogenetic protein 10(Bmp10)
  • 貨號:
    CSB-YP002734MO
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Mouse Bone morphogenetic protein 10(Bmp10)
  • 貨號:
    CSB-EP002734MO
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Mouse Bone morphogenetic protein 10(Bmp10)
  • 貨號:
    CSB-EP002734MO-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Mouse Bone morphogenetic protein 10(Bmp10)
  • 貨號:
    CSB-BP002734MO
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Mouse Bone morphogenetic protein 10(Bmp10)
  • 貨號:
    CSB-MP002734MO
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    Bmp10
  • Uniprot No.:
  • 別名:
    Bmp10Bone morphogenetic protein 10; BMP-10
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    314-421
  • 氨基酸序列
    NAKGNYC KKTPLYIDFK EIGWDSWIIA PPGYEAYECR GVCNYPLAEH LTPTKHAIIQ ALVHLKNSQK ASKACCVPTK LDPISILYLD KGVVTYKFKY EGMAVSECGC R
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth. May reduce cell migration and cell matrix adhesion in breast cancer cell lines.
  • 基因功能參考文獻:
    1. our data show that in a tumor environment BMP9 and BMP10 play different roles and thus blocking their shared receptor ALK1 is maybe not appropriate. Indeed, BMP9, but not BMP10, acts as a quiescence factor on tumor growth, lung metastasis and vessel normalization. PMID: 30165893
    2. CV2 binds directly to BMP10, as determined by co-immunoprecipitation, and inhibits BMP10 from initiating SMAD signaling, as determined by luciferase reporter gene assays. BMP10 and CV2 have important roles in coordinating cardiomyogenesis in progenitor cells. PMID: 28464239
    3. The Prodomain-bound Form of Bone Morphogenetic Protein 10 Is Biologically Active on Endothelial Cells. PMID: 26631724
    4. result was supported by the identification of the regulation by BMP9 and BMP10 of several genes known to be involved in this process PMID: 26056270
    5. BMP10 has an exclusive function in cardiac development, which cannot be substituted by BMP9. PMID: 23812757
    6. Myocardin transactivated Bmp10 via binding of a serum response factor-myocardin complex to a nonconsensus CArG element in the Bmp10 promoter. A myocardin/BMP10 signaling pathway regulates cardiomyocyte proliferation & apoptosis in embryonic heart. PMID: 22996691
    7. BMP9 and BMP10 are important in postnatal vascular remodeling of the retina and BMP10 can substitute for BMP9. PMID: 22566602
    8. the BMP10-Tbx20 signaling cascade is important for ventricular wall development and maturation. PMID: 21890625
    9. Soluble endoglin specifically binds bone morphogenetic proteins 9 and 10 via its orphan domain, inhibits blood vessel formation, and suppresses tumor growth. PMID: 21737454
    10. Furin is the major processing enzyme of the cardiac-specific growth factor bone morphogenetic protein 10. PMID: 21550985
    11. Results describe an essential role of bone morphogenetic protein 10 in regulating cardiac growth and chamber maturation. PMID: 15073151
    12. bone morphogenetic protein 10 in myocardium has a role in cardiac postnatal hypertrophic growth PMID: 16798733

    顯示更多

    收起更多

  • 亞細胞定位:
    Secreted.
  • 蛋白家族:
    TGF-beta family
  • 組織特異性:
    In the embryo, expressed exclusively in the ventricular trabecular myocardium of the developing heart from 9.0 dpc-13.5 dpc. By 16.5 dpc-18.5 dpc, only detectable in atria. Highly expressed in the adult heart where it is found in the right atrium but not
  • 數據庫鏈接:


主站蜘蛛池模板: 亚洲中文字幕无码中文字| 亚洲中国最大av网站| 国产精品高潮呻吟av久久男男| 18禁无遮挡啪啪无码网站| 欧美大荫蒂毛茸茸视频| 粗大猛烈进出高潮视频免费看 | 中文字幕无码精品三级在线电影| 色婷婷亚洲精品综合影院| 欧美日韩亚洲国产在线制服| 又白又嫩毛又多15p| 久久99国产精品久久99果冻传媒| 久久精品无码一区二区三区| 免费无码a片一区二三区| 色综合亚洲一区二区小说| 亚洲中文字幕日产无码2020| 亚洲熟女综合色一区二区三区| 欧美颜射内射中出口爆在线 | 国产精品55夜色66夜色| 免费观看全黄做爰大片国产| 老妇肥熟凸凹丰满刺激| 亚洲中文字幕永久在线不卡| 久久亚洲精品无码观看不卡| 免费看又色又爽又黄的国产软件| 亚洲熟妇少妇任你躁在线观看无码| 精品欧美乱码久久久久久1区2区 | 国内精品久久久久久久影院| 亚洲国产色播av在线| 九九久久精品无码专区| 国产寡妇偷人在线观看| 久久午夜色播影院| 亚洲 熟女 久久 国产| 女人下边被添全过视频的网址| 情欲少妇人妻100篇| 亚洲欧洲日产国产 最新| 精品少妇爆乳无码av无码专区| 69精品人人人人| 国产在线看片免费人成视频| 熟妇的奶头又大又长奶水视频| 国产亚洲欧美在线专区| 老鸭窝视频在线观看| 日日做夜狠狠爱欧美黑人|