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  4. Recombinant Mouse Bone morphogenetic protein 1 (Bmp1), partial

Recombinant Mouse Bone morphogenetic protein 1 (Bmp1), partial

  • 中文名稱：
    Recombinant Mouse Bone morphogenetic protein 1(Bmp1) ,partial
  • 貨號：
    CSB-YP002733MO
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Bone morphogenetic protein 1(Bmp1) ,partial
  • 貨號：
    CSB-EP002733MO
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Bone morphogenetic protein 1(Bmp1) ,partial
  • 貨號：
    CSB-EP002733MO-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Bone morphogenetic protein 1(Bmp1) ,partial
  • 貨號：
    CSB-BP002733MO
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Bone morphogenetic protein 1(Bmp1) ,partial
  • 貨號：
    CSB-MP002733MO
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Bmp1
  • Uniprot No.：
  • 別名：
    Bmp1; Bone morphogenetic protein 1; BMP-1; EC 3.4.24.19; Mammalian tolloid protein; mTld; Procollagen C-proteinase; PCP
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Metalloprotease that plays key roles in regulating the formation of the extracellular matrix (ECM) via processing of various precursor proteins into mature functional enzymes or structural proteins. Thereby participates in several developmental and physiological processes such as cartilage and bone formation, muscle growth and homeostasis, wound healing and tissue repair. Roles in ECM formation include cleavage of the C-terminal propeptides from procollagens such as procollagen I, II and III or the proteolytic activation of the enzyme lysyl oxidase LOX, necessary to formation of covalent cross-links in collagen and elastic fibers. Additional substrates include matricellular thrombospondin-1/THBS1 whose cleavage leads to cell adhesion disruption and TGF-beta activation.
  • 基因功能參考文獻：
    1. Biochemical studies identify a Bmp-mTORC1-Hif1a signaling cascade resulting in upregulation of Glut1 in chondrocytes that is essential for murine skeletal development. PMID: 30446646
    2. Loss of BMP1-like proteinase activity is shown to result in markedly thinned and fragile skin with unusually densely packed collagen fibrils and delayed wound healing. PMID: 27363389
    3. plays crucial role in maintaining extracellular matrix homeostasis essential to root formation and dentin mineralization PMID: 27847137
    4. Bone morphogenetic protein and retinoic acid synergistically specify female germ-cell fate in mice. PMID: 28928204
    5. the proteinases encoded by Bmp1 and Tll1 genes play essential roles in the development and maintenance of mouse dentin and periodontal ligaments. PMID: 28000152
    6. The presented data demonstrate Bmp1/Tll1 products to be of profound importance to bone growth and modeling. PMID: 24419319
    7. Bone morphogenetic protein-1 processes insulin-like growth factor-binding protein 3. PMID: 21697095
    8. during endochondral ossification, BMP and TGFbeta signaling can have antagonistic effects on chondrocyte proliferation and differentiation in vivo PMID: 21297990
    9. BMP-1 protein was expressed in type I and IIa but not in IIb muscle fibers. BMP-1 mRNA levels were unaffected by either food deprivation or hindlimb suspension. PMID: 20658214
    10. periostin supported BMP-1-mediated proteolytic activation of LOX on the extracellular matrix, which promoted collagen cross-linking. PMID: 20181949
    11. products of Bmp1 and Tll1 are responsible for in vivo cleavage of Chordin in mammals PMID: 12808086
    12. processing of the prodomain of OGN by BMP-1 potentiates the ability of OGN to modulate the formation of collagen fibrils PMID: 15292192
    13. BMP1 cleaves LTBP1 at two specific sites, liberating the large latent complex from the extracellular matrix and resulting in consequent activation of TGFbeta1 via cleavage of its prodomain, latency-associated peptide, by non-BMP1-like proteinases. PMID: 17015622
    14. BMP signaling promotes the generation of astrocytes and mature, myelinating oligodendrocytes in vivo but does not affect oligodendrocyte precursor development, thus suggesting tight regulation of BMP signaling to ensure proper gliogenesis PMID: 17391983
    15. Bmp1 processes prl to a 17-kDa anti-angiogenic factor. PMID: 17548836
    16. proteolytic cleavage of the propeptide by BMP-1/TLD proteases plays a critical role in the activation of latent myostatin in vivo PMID: 18286185
    17. FN binds BMP1-like proteinases in vivo and that FN is an important determinant of the in vivo activity levels of BMP1-like proteinases. PMID: 19617627

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  • 亞細胞定位：
    Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Secreted. Note=Co-localizes with POSTN in the Golgi.
  • 蛋白家族：
    Peptidase M12A family
  • 組織特異性：
    At high levels in embryonic maternal deciduum and floor plate region of the neural tube. Less in developing membranous and endochondral bone, submucosa of intestine, dermis of skin and the mesenchyme of spleen and lung.
  • 數(shù)據(jù)庫鏈接：


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