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  4. Recombinant Mouse Betaine--homocysteine S-methyltransferase 1 (Bhmt)

Recombinant Mouse Betaine--homocysteine S-methyltransferase 1 (Bhmt)

  • 中文名稱：
    Recombinant Mouse Betaine--homocysteine S-methyltransferase 1(Bhmt)
  • 貨號：
    CSB-YP002693MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Betaine--homocysteine S-methyltransferase 1(Bhmt)
  • 貨號：
    CSB-EP002693MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Betaine--homocysteine S-methyltransferase 1(Bhmt)
  • 貨號：
    CSB-EP002693MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Betaine--homocysteine S-methyltransferase 1(Bhmt)
  • 貨號：
    CSB-BP002693MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Betaine--homocysteine S-methyltransferase 1(Bhmt)
  • 貨號：
    CSB-MP002693MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Bhmt
  • Uniprot No.：
  • 別名：
    BhmtBetaine--homocysteine S-methyltransferase 1; EC 2.1.1.5
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-407
  • 氨基酸序列
    APVAGKKAK KGILERLNAG EVVIGDGGFV FALEKRGYVK AGPWTPEAAV EHPEAVRQLH REFLRAGSNV MQTFTFYASE DKLENRGNYV AEKISGQKVN EAACDIARQV ADEGDALVAG GVSQTPSYLS CKSEVEVKKI FRQQLEVFMK KNVDFLIAEY FEHVEEAVWA VEALKASGKP VAATMCIGPE GDLHGVPPGE CAVRLVKAGA SIVGVNCHFD PSVSLQTVKL MKEGLEAARL KAYLMSQPLA YHTPDCGKQG FIDLPEFPFG LEPRVATRWD IQKYAREAYN LGVRYIGGCC GFEPYHIRAI AEELAPERGF LPPASEKHGS WGSGLDMHTK PWIRARARKE YWQNLRIASG RPYNPSMSRP DAWGVTKGAA ELMQQKEATT EQQLRELFEK QKFKSAQ
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Involved in the regulation of homocysteine metabolism. Converts betaine and homocysteine to dimethylglycine and methionine, respectively. This reaction is also required for the irreversible oxidation of choline.
  • 基因功能參考文獻：
    1. Data indicate that improved Sp1 transcription factor (Sp1) and betaine homocysteine-S-methyltransferase (BHMT) expression are involved in the effects of zinc on oxidative stress. PMID: 29204947
    2. Bhmt(-/-) mice maintained on a control diet had elevated concentrations of homocysteine, reduced total brain magnetic resonance imaging volume, as well as impaired reference and short-term memories. PMID: 28715642
    3. BHMT expression is robustly regulated by taurine. PMID: 26481005
    4. It was concluded that the BHMT pathway is a major route for the elimination of Hcy in mice and that the methionine synthase pathway has little excess capacity to methylate the Hcy that accumulates when the BHMT pathway is blocked. PMID: 23014492
    5. mouse blastocysts are unusual in being able to generate AdoMet not only by the ubiquitous folate-dependent mechanism but also from betaine metabolized by BHMT PMID: 22847001
    6. a role for BHMT in energy homeostasis. PMID: 22362777
    7. BHMT has an important role in Hcy, choline, and one-carbon homeostasis PMID: 21878621
    8. The BHMT/betaine system directly protects hepatocytes from homocysteine-induced injury but not tunicamycin-induced injury, including an endoplasmic reticulum stress response, lipid accumulation, and cell death. PMID: 17705221

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  • 亞細胞定位：
    Cytoplasm.
  • 數據庫鏈接：


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