Recombinant Mouse Beta-crystallin B2 (Crybb2)

中文名稱：

Recombinant Mouse Beta-crystallin B2(Crybb2)
貨號(hào)：

CSB-YP006013MO
規(guī)格：
來源：

Yeast
其他：

中文名稱：

Recombinant Mouse Beta-crystallin B2(Crybb2)
貨號(hào)：

CSB-EP006013MO
規(guī)格：
來源：

E.coli
其他：

中文名稱：

Recombinant Mouse Beta-crystallin B2(Crybb2)
貨號(hào)：

CSB-EP006013MO-B
規(guī)格：
來源：

E.coli
共軛：

Avi-tag Biotinylated
E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.
其他：

中文名稱：

Recombinant Mouse Beta-crystallin B2(Crybb2)
貨號(hào)：

CSB-BP006013MO
規(guī)格：
來源：

Baculovirus
其他：

中文名稱：

Recombinant Mouse Beta-crystallin B2(Crybb2)
貨號(hào)：

CSB-MP006013MO
規(guī)格：
來源：

Mammalian cell
其他：

產(chǎn)品詳情
產(chǎn)品評(píng)價(jià)
靶點(diǎn)詳情

產(chǎn)品詳情

純度：

>85% (SDS-PAGE)
基因名：

Crybb2
Uniprot No.：

P62696
別名：

Crybb2Beta-crystallin B2; Beta-B2 crystallin; Beta-crystallin Bp
種屬：

Mus musculus (Mouse)
蛋白長(zhǎng)度：

Full Length of Mature Protein
表達(dá)區(qū)域：

2-205
氨基酸序列

ASDHQTQAG KPQPLNPKII IFEQENFQGH SHELSGPCPN LKETGMEKAG SVLVQAGPWV GYEQANCKGE QFVFEKGEYP RWDSWTSSRR TDSLSSLRPI KVDSQEHKII LYENPNFTGK KMEIVDDDVP SFHAHGYQEK VSSVRVQSGT WVGYQYPGYR GLQYLLEKGD YKDNSDFGAP HPQVQSVRRI RDMQWHQRGA FHPSS
蛋白標(biāo)簽：

Tag?type?will?be?determined?during?the?manufacturing?process.

The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
產(chǎn)品提供形式：

Lyophilized powder
Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
復(fù)溶：

We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
儲(chǔ)存條件：

Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
保質(zhì)期：

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
貨期：

Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
注意事項(xiàng)：

Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
Datasheet ：

Please contact us to get it.

產(chǎn)品評(píng)價(jià)

靶點(diǎn)詳情

功能：

Crystallins are the dominant structural components of the vertebrate eye lens.
基因功能參考文獻(xiàn)：
1. Tmsb4X was up-regulated in Crybb2 mutant brain. Additionally, Tmsb4X was co-expressed with Crybb2 at actin-enriched cell ruffles. Over-expression of Tmsb4X in cultured hippocampal neurons inhibited dendritogenesis, which phenocopied Crybb2 knock-down. PMID: 29864422
2. In conclusion, CRYBB2 regulates expression of different lncRNAs to influence ovary development PMID: 27666820
3. ovaries from female Crybb2(-/-) mice exhibited significantly reduced numbers of primordial, secondary and pre-ovulatory follicles when compared with WT mice, while the rate of atretic follicles was also increased PMID: 25245288
4. BetaB2-crystallin has a role in hippocampal function and behavioral phenotypes. PMID: 24096375
5. Removal of both amino- and carboxyl-terminal extensions of recombinant crystallin beta B2 increases the entropy and enthalpy of dimer binding but to a lesser degree than occurs in truncated recombinant beta A3 crystallin. PMID: 14717595
6. Thus, some of the fiber differentiation processes are likely mediated by RTK-dependent but Ras-independent pathways. PMID: 16889766
7. betaB2-crystallin is expressed in developing and mature sperm and mice of both sexes harboring the Philly mutation in the betaB2-crystallin gene are subfertile when analyzed on a Swiss Webster genetic background. PMID: 17392687
8. presence of measurable interactions between MIP26 and all crystallins, with the extent of interactions decreasing from alphaA- and alphaB-crystallin to betaB2- and gammaC-crystallin. PMID: 18004741
9. These results confirm the third allele of Crybb2 in the mouse that also affected exon 6 and the fourth Greek key motif. Moreover, expression analysis of Crybb2 identified for the first time distinct regions of expression in the brain. PMID: 18385073
10. BetaB2-crystallin is not essential for the normal development of a transparent lens in the mouse. It plays an increasingly important role in maintaining the transparency of the lens after birth. PMID: 18719080
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蛋白家族：

Beta/gamma-crystallin family
數(shù)據(jù)庫鏈接：

KEGG: mmu:12961

STRING: 10090.ENSMUSP00000031295

UniGene: Mm.1215