在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse B-cell lymphoma/leukemia 11A (Bcl11a)

Recombinant Mouse B-cell lymphoma/leukemia 11A (Bcl11a)

  • 中文名稱：
    Recombinant Mouse B-cell lymphoma/leukemia 11A(Bcl11a)
  • 貨號：
    CSB-YP865592MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse B-cell lymphoma/leukemia 11A(Bcl11a)
  • 貨號：
    CSB-EP865592MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse B-cell lymphoma/leukemia 11A(Bcl11a)
  • 貨號：
    CSB-EP865592MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse B-cell lymphoma/leukemia 11A(Bcl11a)
  • 貨號：
    CSB-BP865592MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse B-cell lymphoma/leukemia 11A(Bcl11a)
  • 貨號：
    CSB-MP865592MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Bcl11a; Ctip1; Evi9; Kiaa1809B-cell lymphoma/leukemia 11A; BCL-11A; B-cell CLL/lymphoma 11A; COUP-TF-interacting protein 1; Ecotropic viral integration site 9 protein; EVI-9
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-773
  • 氨基酸序列
    MSRRKQGKPQ HLSKREFSPE PLEAILTDDE PDHGPLGAPE GDHDLLTCGQ CQMNFPLGDI LIFIEHKRKQ CNGSLCLEKG VDKPPSPSPI EMKKASNPVE VGIQVTPEDD DCLSTSSRGI CPKQEHIADK LLHWRGLSSP RSAHGALIPT PGMSAEYAPQ GICKDEPSSY TCTTCKQPFT SAWFLLQHAQ NTHGLRIYLE SEHGSPLTPR VGIPSGLGAE CPSQPPLHGI HIADNNPFNL LRIPGSVSRE ASGLAEGRFP PTPPLFSPPP RHHLDPHRIE RLGAEEMALA THHPSAFDRV LRLNPMAMEP PAMDFSRRLR ELAGNTSSPP LSPGRPSPMQ RLLQPFQPGS KPPFLATPPL PPLQSAPPPS QPPVKSKSCE FCGKTFKFQS NLVVHRRSHT GEKPYKCNLC DHACTQASKL KRHMKTHMHK SSPMTVKSDD GLSTASSPEP GTSDLVGSAS SALKSVVAKF KSENDPNLIP ENGDEEEEED DEEEEEEEEE EEEELTESER VDYGFGLSLE AARHHENSSR GAVVGVGDEG RALPDVMQGM VLSSMQHFSE AFHQVLGEKH KRSHLAEAEG HRDTCDEDSV AGESDRIDDG TVNGRGCSPG ESASGGLSKK LLLGSPSSLS PFSKRIKLEK EFDLPPAAMP NTENVYSQWL AGYAASRQLK DPFLTFGDSR QSPFASSSEH SSENGSLRFS TPPGELDGGI SGRSGTGSGG STPHISGPGP GRPSSKEGRR SDTCPSHTPV RRSTPRAQDV WQFSDGSSRT LKF
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Transcription factor. Associated with the BAF SWI/SNF chromatin remodeling complex. Binds to the 5'-TGACCA-3' sequence motif in regulatory regions of target genes. May play a role in hematopoiesis. Essential factor in lymphopoiesis, required for B-cell formation in fetal liver. May function as a modulator of the transcriptional repression activity of NR2F2.
  • 基因功能參考文獻：
    1. Our studies define a mechanism for BCL11A in regulation of hematopoietic stem cell function PMID: 27653684
    2. Bcl11a enhancer-deleted mice, Bcl11a(Deltaenh), phenocopy the BCL11A-null state with respect to alterations of globin expression. PMID: 27707736
    3. data identify Ctip1 as a critical control over sensory cortex development PMID: 27100196
    4. Bcl11a haploinsufficiency in mice causes impaired cognition, abnormal social behavior, and microcephaly in accordance with the human phenotype PMID: 27453576
    5. deletion of Bcl11a alters the regulation of hematopoietic stem cell quiescence, self-renewal, and fate choice PMID: 26390863
    6. This study showed that the expression of Sema3c is increased in migrating Bcl11a-deficient neurons and that Bcl11a is a direct negative regulator of Sema3c transcription PMID: 26182416
    7. The results of this study support a role for CTIP1 on the specification of the Subcerebral Projection Neurons in layer 5 through the repression of TBR1 and the promotion of CTIP2 expression. PMID: 25972180
    8. BCL11A is an essential, lineage-specific factor that regulates plasmacytoid dendritic cell development, supporting a model wherein differentiation into pDCs represents a primed "default" pathway for common dendritic cell progenitors. PMID: 24591644
    9. Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo. PMID: 23741395
    10. BCL11A contains F/YSXXLXXL/Y motifs that mediate highly selective binding to the LBDs of orphan nuclear receptors NR2E1/TLX, NR2E3/PNR and the NR2F/COUP-TF family. These motifs are required for BCL11A/COUP-TFII-mediated repression of foetal globin genes and a lncRNA termed Bgl3. The motifs are conserved in other nuclear receptor cofactors such as NSD1, constituting a new signature motif related to LXXLL and the CoRNR box. PMID: 23975195
    11. Immunohistochemical staining of mouse brain showed strong expression of BCL11A in the cortical regions and also in the pyramidal cell layers in the CA1 and CA3 regions of the hippocampus. PMID: 23975195
    12. data support an important role for the KLF1-BCL11A axis in erythroid maturation and developmental regulation of globin expression PMID: 23361909
    13. Overexpression of Bcl2 and Mdm2, or p53 deficiency, rescues both lethality and proliferative defects in Bcl11a-deficient early B cells. PMID: 23230003
    14. BCL11A is required for silencing of gamma-globin expression in adult animals yet dispensable for red cell production; inactivation of BCL11A in sickle cell disease (SCD) transgenic mice corrects defects associated with SCD through HbF induction PMID: 21998251
    15. Bcl11a is essential for postnatal development and normal lymphopoiesis. PMID: 12717432
    16. CTIP1 and CTIP2 have roles in the development and function of both the central nervous and immune systems PMID: 15465497
    17. Bcl11a is a SUMOylated protein and recruits SUMO-conjugation enzymes in its nuclear body. PMID: 18681895
    18. deregulated Bcl11a cooperates with Nf1 in leukemogenesis PMID: 18948576
    19. BCL11A is a critical mediator of species-divergent globin switching PMID: 19657335

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus. Note=Associates with the nuclear body. Colocalizes with SUMO1 and SENP2 in nuclear speckles.
  • 組織特異性：
    Isoforms are expressed in a tissue-specific fashion. Isoforms 1, isoform 2, and isoform 3 are expressed at similar levels in testis, kidney and spleen. Isoform 1 is expressed in the stomach, and isoform 2 is expressed exclusively in the lung. Overexpressi
  • 數(shù)據(jù)庫鏈接：


主站蜘蛛池模板： 精品人妻无码一区二区三区性| 日本工口里番无遮█彩色| 牲交a欧美牲交aⅴ免费一| 亚洲 a v无 码免 费 成 人 a v| 狠狠躁夜夜躁人人爽超碰97香蕉| 国产又黄又刺激又高潮的网站| 国产成人亚洲无吗淙合青草| 亚洲精品国产av成拍色拍婷婷| 国产露脸无套对白在线播放| 又色又污又爽又黄的网站| 欧美人与动人物牲交免费观看 | 国产精品夜夜春夜夜爽久久小说| 337p日本欧洲亚洲大胆裸体艺术| 久久777国产线看观看精品| 国产福利姬喷水福利在线观看 | 久久香综合精品久久伊人| 亚洲爆乳成av人在线视水卜| 五月天激情国产综合婷婷婷| 黄网站欧美内射| 伊人婷婷色香五月综合缴缴情| 97免费人妻在线视频| 国产精品爽爽久久久久久| 俄罗斯大荫蒂女人毛茸茸| 国产成久久免费精品av片| 欧美人与性动交g欧美精器| 国产蜜臀av在线一区尤物| 在线精品视频一区二区| 精品久久久久中文字幕app| 午夜男女很黄的视频| 日韩精品乱码av一区二区| 精品免费国产一区二区| 女人被男人躁得好爽免费视频 | 国产麻豆精品av在线观看| 精品国产一区二区三区av色诱| 精品无码专区毛片| 久久人人爽人人爽人人爽| 国产婷婷亚洲999精品小说| 国内精品一区二区三区| 亚洲一区av在线观看| 国产精品高潮呻吟av久久小说 | 久久99国产精一区二区三区|