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  4. Recombinant Mouse B-cell CLL/lymphoma 9-like protein (Bcl9l), partial

Recombinant Mouse B-cell CLL/lymphoma 9-like protein (Bcl9l), partial

  • 中文名稱：
    Recombinant Mouse B-cell CLL/lymphoma 9-like protein(Bcl9l) ,partial
  • 貨號：
    CSB-YP717998MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse B-cell CLL/lymphoma 9-like protein(Bcl9l) ,partial
  • 貨號：
    CSB-EP717998MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse B-cell CLL/lymphoma 9-like protein(Bcl9l) ,partial
  • 貨號：
    CSB-EP717998MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse B-cell CLL/lymphoma 9-like protein(Bcl9l) ,partial
  • 貨號：
    CSB-BP717998MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse B-cell CLL/lymphoma 9-like protein(Bcl9l) ,partial
  • 貨號：
    CSB-MP717998MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Bcl9l; B9lB-cell CLL/lymphoma 9-like protein; B-cell lymphoma 9-like protein; BCL9-like protein; BCL9-related beta-catenin-binding protein; Protein BCL9-2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional regulator that acts as an activator. Promotes beta-catenin transcriptional activity. Plays a role in tumorigenesis. Enhances the neoplastic transforming activity of CTNNB1.
  • 基因功能參考文獻：
    1. BCL9-2 induces ER positive breast cancers in vivo, regulates ER expression by a novel ss-catenin independent mechanism in breast cancer cells. PMID: 25149534
    2. Data show that the GCM1/syncytin-B pathway is significantly downregulated in the placenta of BCL9L-deficient mice and that the fusion and differentiation of ST-II cells are blocked. PMID: 22109522
    3. BCL9-2 promotes early phases of intestinal tumor progression in humans and in transgenic mice. BCL9-2 increases the expression of a subset of canonical Wnt target genes but also regulates genes that are required for early stages of tumor progression. PMID: 21703997
    4. We demonstrated that nuclear B9L expression was closely associated with the high nuclear grade cancer phenotype and the expression of ErbB2/HER-2 in breast cancers. PMID: 17309600
  • 亞細胞定位：
    Nucleus. Note=localized also in punctate nuclear bodies as well in the cytoplasm. Colocalizes with CTNNB1.
  • 蛋白家族：
    BCL9 family
  • 組織特異性：
    Expressed in kidney, liver, lung, testis, brain, spleen, heart and skeletal muscle. Highly expressed in numerous colorectal tumors compared to corresponding non-cancerous tissues.
  • 數據庫鏈接：


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