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  4. Recombinant Mouse Atrophin-1 (Atn1), partial

Recombinant Mouse Atrophin-1 (Atn1), partial

  • 中文名稱：
    Recombinant Mouse Atrophin-1(Atn1) ,partial
  • 貨號：
    CSB-YP002305MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Atrophin-1(Atn1) ,partial
  • 貨號：
    CSB-EP002305MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Atrophin-1(Atn1) ,partial
  • 貨號：
    CSB-EP002305MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Atrophin-1(Atn1) ,partial
  • 貨號：
    CSB-BP002305MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Atrophin-1(Atn1) ,partial
  • 貨號：
    CSB-MP002305MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Atn1
  • Uniprot No.：
  • 別名：
    Atn1; DrplaAtrophin-1; Dentatorubral-pallidoluysian atrophy protein homolog
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional corepressor. Corepressor of MTG8 transcriptional repression. Has some intrinsic repression activity which is independent of the number of the poly-Q repeats. Recruits NR2E1 to repress transcription. Promotes vascular smooth cell (VSMC) migration and orientation.
  • 基因功能參考文獻：
    1. These results support the model that poly-Q expanded Atrophin-1 proteins cause dentatorubral-pallidoluysian atrophy in a manner independent of any functional interaction with wild-type Atrophin-1 proteins. PMID: 19681162
    2. mutant atropphin with polyglutamine expansion does not simply function in a dominant negative manner PMID: 16407196
    3. TLX interacts with atrophin1 (Atn1), a corepressor that is involved in human neurodegenerative dentatorubral-pallidoluysian atrophy (DRPLA) and that is essential for development of multiple tissues. PMID: 16702404
    4. Atrophin-1 and the short form of Atrophin-2 can act as potent and evolutionarily conserved transcriptional activators. PMID: 17150957
    5. Fat1 and Atrs 1,2 act in concert after vascular injury but show further that distinct Atr isoforms have disparate effects on VSMC directional migration. PMID: 19131340

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  • 亞細胞定位：
    Cytoplasm, perinuclear region. Cell junction. Nucleus.
  • 組織特異性：
    Widely expressed. Most abundant in the brain.
  • 數據庫鏈接：


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