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  4. Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Arap1), partial

Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 (Arap1), partial

  • 中文名稱：
    Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1(Arap1) ,partial
  • 貨號：
    CSB-YP708957MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1(Arap1) ,partial
  • 貨號：
    CSB-EP708957MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1(Arap1) ,partial
  • 貨號：
    CSB-EP708957MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1(Arap1) ,partial
  • 貨號：
    CSB-BP708957MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1(Arap1) ,partial
  • 貨號：
    CSB-MP708957MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    Arap1; Centd2; Kiaa0782Arf-GAP with Rho-GAP domain; ANK repeat and PH domain-containing protein 1; Centaurin-delta-2; Cnt-d2
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Phosphatidylinositol 3,4,5-trisphosphate-dependent GTPase-activating protein that modulates actin cytoskeleton remodeling by regulating ARF and RHO family members. Is activated by phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3) binding. Can be activated by phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4,5)P2) binding, albeit with lower efficiency. Has a preference for ARF1 and ARF5.
  • 基因功能參考文獻：
    1. competitive analytical gel-filtration chromatography and isothermal titration calorimetry (ITC) results showed that ARAP1 could compete with Cbl for CIN85 binding, which provides a biochemical basis for the regulatory roles of ARAP1 in the CIN85-mediated EGFR internalizing process. PMID: 29589748
    2. Quantitative trait loci genes analysis reveals association between T2D risk variants at the ARAP1/STARD10 locus and STARD10 but not ARAP1 expression. PMID: 28132686
    3. Increased ARAP1 expression might contribute to type 2 diabetes susceptibility at this Genome-wide association studies locus. PMID: 24439111
    4. Arap1 is highly expressed in the renal vasculature, and its expression is suppressed by angiotensin II. PMID: 22357923
    5. afadin regulates the cyclical activation and inactivation of Rap1, Rac1, and RhoA through SPA-1 and ARAP1. PMID: 19589776

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  • 亞細胞定位：
    Cytoplasm. Golgi apparatus, Golgi stack membrane; Peripheral membrane protein. Cell membrane.
  • 數據庫鏈接：


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