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  4. Recombinant Mouse Amiloride-sensitive sodium channel subunit gamma (Scnn1g), partial

Recombinant Mouse Amiloride-sensitive sodium channel subunit gamma (Scnn1g), partial

  • 中文名稱：
    小鼠Scnn1g重組蛋白
  • 貨號：
    CSB-YP896238MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Scnn1g重組蛋白
  • 貨號：
    CSB-EP896238MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Scnn1g重組蛋白
  • 貨號：
    CSB-EP896238MO-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Scnn1g重組蛋白
  • 貨號：
    CSB-BP896238MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Scnn1g重組蛋白
  • 貨號：
    CSB-MP896238MO
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Scnn1g
  • Uniprot No.：
  • 別名：
    Scnn1g; Amiloride-sensitive sodium channel subunit gamma; Epithelial Na(+) channel subunit gamma; Gamma-ENaC; Gamma-NaCH; Nonvoltage-gated sodium channel 1 subunit gamma; SCNEG
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
  • 基因功能參考文獻：
    1. Mouse cells conditionally overexpressing gamma ENAC had enhanced apical Na(+) entry increased the basolateral cell surface expression of Na,K-ATPase by inhibiting p38 kinase-mediated endocytosis of Na,K-ATPase. PMID: 24179170
    2. TMPRSS4 primarily activates ENaC by cleaving basic residues within the tract gammaK173-K186 distal to the furin cleavage site, thereby releasing a previously defined key inhibitory tract encompassing gammaR158-F168 from the gamma-subunit. PMID: 21993886
    3. estrogen regulates expression and function of epithelial sodium channel gamma in osteoblasts PMID: 21624334
    4. Il-6 activates ENaC-gamma channels in cortical collecting duct cells. PMID: 20504903
    5. residues within Gln573-Arg583 of gammaENaC are necessary for normal channel gating PMID: 12897071
    6. Scnn1g is a PPARgamma target gene in the renal collecting duct. PMID: 16007095
    7. Aldosterone-induced transcriptional up-regulation of the channel's beta- and gamma-subunit (beta ENaC and gamma ENaC) and of the serum- and glucocorticoid-inducible kinase 1 (SGK1) was similar in colon tissue from Liddle and wild-type animals PMID: 18006588
    8. SGK1 is essential for optimal processing of ENaC but is not required for activation of the channel by aldosterone PMID: 18385268
    9. P2Y2 receptor activation by nucleotides thus provides physiologically important regulation of ENaC and electrolyte handling in mammalian kidney PMID: 18981175
    10. Plasmin activates epithelial Na+ channels by cleaving the gamma subunit PMID: 18981180

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  • 亞細胞定位：
    Apical cell membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Amiloride-sensitive sodium channel (TC 1.A.6) family, SCNN1G subfamily
  • 組織特異性：
    Lung and kidney.
  • 數(shù)據(jù)庫鏈接：


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