在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Alpha-actinin-4 (Actn4), partial

  • 中文名稱:
    Recombinant Mouse Alpha-actinin-4 (Actn4), partial
  • 貨號:
    CSB-EP001244MO
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    37.2 kDa
  • 表達區域:
    1-267aa
  • 氨基酸序列
    MVDYHAANQAYQYGPNSGGGNGAGGGGSMGDYMAQEDDWDRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPKPERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQDISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPELIEYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSFYH
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 3-7 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. Probably involved in vesicular trafficking via its association with the CART complex. The CART complex is necessary for efficient transferrin receptor recycling but not for EGFR degradation. Involved in tight junction assembly in epithelial cells probably through interaction with MICALL2. Links MICALL2 to the actin cytoskeleton and recruits it to the tight junctions. May also function as a transcriptional coactivator, stimulating transcription mediated by the nuclear hormone receptors PPARG and RARA.
  • 基因功能參考文獻:
    1. Focal segmental glomerulosclerosis Actn4 mutation promotes podocyte detachment through maladaptation to periodic stretch. PMID: 29378953
    2. ACTN4 is a transcriptional coactivator of NF-kappaB. PMID: 25411248
    3. sLZIP negatively regulates skeletal muscle differentiation via interaction with ACTN4. PMID: 24375477
    4. the C-terminal tail of alpha-actinin-4 is essential for its function in cell migration and adhesion to substratum. PMID: 23466492
    5. Dexamethasone mey protect actin cytoskeleton stabilization from adriamycin-induced podocyte injury via alpha-actinin-4. PMID: 22804863
    6. anti-dsDNA Fab may enhance F-actin formation by the proprietary modification of alpha-actinin-4 PMID: 22929799
    7. Together, these results indicate that alpha-actinin and the actin cytoskeleton are important components of the cisternal organelle that are probably required to stabilize the AIS. PMID: 21940706
    8. Results suggest that ACTN4 is essential for maintaining normal spreading, motility, cellular and nuclear cross-sectional area, and contractility of lung fibroblasts by maintaining the balance between transcellular contractility and cell-adhesion. PMID: 21085685
    9. newly developed mouse model of ACTN4-associated FSGS suggests a cause-and-effect relationship between actin cytoskeleton dysregulation by mutant alpha-actinin-4 and the deterioration of the nephrin-supported slit diaphragm complex. PMID: 12707390
    10. nonsarcomeric alpha-actinin-4 is involved in the regulation of cell movement PMID: 12782671
    11. ACTN4 has a role promoting tumorigenicity and regulating cell motility PMID: 15048094
    12. FSGS-associated Actn4 impairs cytoskeletal dynamcs in podocytes. PMID: 16837921
    13. alpha-actinin-4 interacts with integrins and strengthens the podocyte-GBM interaction thereby stabilizing glomerular architecture and preventing disease PMID: 17082197
    14. The different genetic defects in Actn4 produce a spectrum of glomerular morphologic lesions depending on the specific combination of normal and/or defective alleles. PMID: 18185509
    15. Although actinin-4 bound to JRAB/MICAL-L2 without Rab13, the actinin-4-JRAB/MICAL-L2 interaction was enhanced by Rab13 activation. PMID: 18332111
    16. Alpha-actinin-4 K256E triggers several metabolic abnormalities, which may lead to glomerular epithelial cell injury and glomerulosclerosis. PMID: 19640905

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Cell junction. Cytoplasm, cytoskeleton, stress fiber. Cytoplasm, perinuclear region.
  • 蛋白家族:
    Alpha-actinin family
  • 數據庫鏈接:


主站蜘蛛池模板: 国产麻豆md传媒视频| 日韩视频 中文字幕 视频一区| 国产精品视频二区不卡| 亚洲午夜国产精品无码老牛影视| 日产亚洲一区二区三区| 电影久久久久久| 久久不见久久见免费视频观看| 人妻无码一区二区三区| 亚洲国产精品一区第二页| 亚洲国产成人久久综合同性| 久久久久久夜精品精品免费啦| 影视先锋av资源噜噜| 亚洲最大成人网色| 久久国产午夜精品理论片| 99久久er热在这里只有精品99| 国产高清在线a视频大全| 亚洲欧洲∨国产一区二区三区| 欧美亚洲国产第一精品久久| 48沈阳熟女高潮嗷嗷叫| 亚洲狠狠婷婷综合久久蜜芽| 日日躁狠狠躁狠狠爱| 丰满少妇夜夜爽爽高潮水| 久久久久久av无码免费看大片| 强开小婷嫩苞又嫩又紧视频韩国| 午夜男女爽爽影院免费视频| 人成午夜免费视频无码| 午夜精品久久久久久久无码 | 久久久精品456亚洲影院| 精品无码一区二区三区的天堂| 日韩欧美一区二区三区免费观看| 亚洲中文字幕丝祙制服| 日韩人妻少妇一区二区三区| 日本阿v网站在线观看中文| 一本色综合网久久| 120秒试看无码体验区| 在线观看午夜亚洲一区| 在线观看无码不卡av| 成人性三级欧美在线观看| 亚洲精品国产一区二区的区别| 久久五月精品中文字幕| 国产精品青青在线麻豆|