在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Aldo-keto reductase family 1 member A1 (Akr1a1)

In Stock
  • 中文名稱:
    Recombinant Mouse Aldo-keto reductase family 1 member A1 (Akr1a1)
  • 貨號:
    CSB-EP878064MO
  • 規格:
    ¥1536
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 95% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
    Akr1a1
  • Uniprot No.:
  • 別名:
    Alcohol dehydrogenase [NADP+;Aldehyde reductase;Glucuronate reductase;EC 1.1.1.19;Glucuronolactone reductase
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    43.9 kDa
  • 表達區域:
    2-325aa
  • 氨基酸序列
    TASSVLLHTGQKMPLIGLGTWKSEPGQVKAAIKHALSAGYRHIDCASVYGNETEIGEALKESVGSGKAVPREELFVTSKLWNTKHHPEDVEPALRKTLADLQLEYLDLYLMHWPYAFERGDNPFPKNADGTVRYDSTHYKETWKALEVLVAKGLVKALGLSNFNSRQIDDVLSVASVRPAVLQVECHPYLAQNELIAHCHARGLEVTAYSPLGSSDRAWRHPDEPVLLEEPVVLALAEKHGRSPAQILLRWQVQRKVICIPKSINPSRILQNIQVFDFTFSPEEMKQLDALNKNWRYIVPMITVDGKRVPRDAGHPLYPFNDPY
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols. Displays enzymatic activity towards endogenous metabolites such as aromatic and aliphatic aldehydes, ketones, monosaccharides and bile acids, with a preference for negatively charged substrates, such as glucuronate and succinic semialdehyde. Plays an important role in ascorbic acid biosynthesis by catalyzing the reduction of D-glucuronic acid and D-glucurono-gamma-lactone. Functions as a detoxifiying enzyme by reducing a range of toxic aldehydes. Reduces methylglyoxal and 3-deoxyglucosone, which are present at elevated levels under hyperglycemic conditions and are cytotoxic. Involved in the detoxification of lipid-derived aldehydes like acrolein. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs. Displays no reductase activity towards retinoids.
  • 基因功能參考文獻:
    1. Data (including data from studies in knockout and transgenic mice) suggest that Akr1a1 in liver is involved in bioactivation of xenobiotic/carcinogen thioacetamide (TAA); Akr1a-/- knockout mice are resistant to TAA-induced liver injury/hepatotoxicity. PMID: 29763686
    2. Akr1A1 gene knockout mice exhibit insufficient serum ascorbic acid levels, abnormal bone development and osteoporosis. PMID: 28060768
    3. These results suggest that Akr1a might be involved in the metabolism of steroids and other carbonyl-containing compounds. PMID: 27888021
    4. Aldehyde reductase exerts a protective effect against carbon tetrachloride-induced hepatic steatosis by replenishing ascorbic acid via its antioxidative properties. PMID: 27501753
    5. The crystal structure of AKR1a4 in its apo form at high resolution. PMID: 23143230

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm, cytosol. Apical cell membrane.
  • 蛋白家族:
    Aldo/keto reductase family
  • 組織特異性:
    Widely expressed.
  • 數據庫鏈接:


主站蜘蛛池模板: 免费国产成人高清在线观看网站| 免费啪视频在线观看视频网页| 最近最好的中文字幕2019免费| 亚洲成av 人片在线观看无码| 亚洲精品久久午夜麻豆| 日本少妇被黑人猛cao| 亚洲aⅴ无码成人网站国产app| 99国产精品白浆在线观看免费| 高潮内射免费看片| 免费人成网站在线观看不卡| 大伊香蕉在线精品视频75| 欧美成人精品第一区| 亚洲一区av无码专区在线观看| 女人大荫蒂毛茸茸视频| 无码专区天天躁天天躁在线| 琪琪秋霞午夜av影视在线| 2021在线不卡国产麻豆| 成人试看120秒体验区| 美女裸体无遮挡免费视频网站| 国产成人免费ā片在线观看老同学| 大肉大捧一进一出视频出来呀| 亚洲熟妇丰满大屁股熟妇图片| 伊人久久综合无码成人网| 久久综合久久久久88| 亚洲午夜性猛春交xxxx| 亚洲性无码一区二区三区| 影音先锋日日狠狠久久| 亚洲欧美日韩国产精品一区| 中文字幕亚洲欧美在线不卡 | 亚洲婷婷五月激情综合app| 在线亚洲精品国产成人av剧情| 波多野美乳人妻hd电影欧美| 天堂网在线最新版www资源网| 久久精品亚洲精品国产色婷| 亚洲精品人成网线在播放va| 欧美一区二区三区| 一本久道高清无码视频 | 最新亚洲春色av无码专区| 超碰aⅴ人人做人人爽| 韩国 欧美 日产 国产精品| 亚洲国产欧美在线人成最新|