在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Acid sphingomyelinase-like phosphodiesterase 3b (Smpdl3b)

In Stock
  • 中文名稱:
    小鼠Smpdl3b重組蛋白
  • 貨號:
    CSB-EP021850MO
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Smpdl3b
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    57.1 kDa
  • 表達區域:
    19-456aa
  • 氨基酸序列
    QLGRFWHISDLHLDPNYTVSKDPLQVCPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQSNRIYNQVAELWRPWLSNESYALFKRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNKAWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNLKDLVTYFLNLRQANVQETPRWEQEYRLTEAYQVPDASVSSMHTALTRIASEPHILQRYYVYNSVSYNHLTCEDSCRIEHVCAIQHVAFNTYATCLHGLGAKLVPGFLLILTLLPSLHVLEVL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro).
  • 基因功能參考文獻:
    1. These results demonstrate that radiation injury induces early cytoskeletal remodeling, down-regulation of SMPDL3b, and elevation of cellular ceramide levels. Overexpression of SMPDL3b and pretreatment with rituximab confer a radioprotective effect in cultured podocytes. PMID: 27836988
    2. Although a potential substrate for SMPDL3B is sphingomyelin, we identify other possible substrates such as CDP-choline, ATP, and ADP. PMID: 27687724
    3. our results identify the membrane-modulating enzyme SMPDL3B as a negative regulator of TLR signaling that functions at the interface of membrane biology and innate immunity. PMID: 26095358
    4. SMPDL3b may be an important modulator of podocyte function by shifting suPAR-mediated podocyte injury from a migratory phenotype to an apoptotic phenotype and that it represents a novel therapeutic glomerular disease target PMID: 24925721
  • 亞細胞定位:
    Secreted. Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族:
    Acid sphingomyelinase family
  • 組織特異性:
    Macrophages and dendritic cells.
  • 數據庫鏈接:


主站蜘蛛池模板: 日韩av中文无码影院| 国产av无码专区国产乱码| 欧美疯狂做受xxxxx高潮| 亚洲欧美国产毛片在线| 国产成人欧美综合在线影院| 揄拍成人国产精品视频| 免费无码不卡视频在线观看| 亚洲精品第一国产综合境外资源 | 国产98色在线 | 日韩| 国产麻豆天美果冻无码视频| 国产免国产免费| 亚洲欧美国产双大乳头| 偷窥国产亚洲免费视频| 92午夜福利少妇系列| 高清免费精品国自产拍| 人妻聚色窝窝人体www一区| 久久午夜福利电影| 成人性生交大片免费看r链接 | 337p日本欧洲亚洲大胆张筱雨| 亚洲a∨无码男人的天堂| 久久躁狠狠躁夜夜av| 国产精品久免费的黄网站| 中文天堂在线www最新版官网| 亚洲mv国产mv在线mv综合试看 | 蜜桃视频网站| 久久97久久97精品免视看秋霞| 中文字幕人妻av一区二区| 羞涩的丰满人妻40p| 国产在线视频主播区| 超碰aⅴ人人做人人爽欧美| 日本熟妇浓毛hdsex| 国产精品久久久久久吹潮| 无码人妻丰满熟妇精品区| 国产白丝精品爽爽久久蜜臀| 国产精品三级av三级av三级| 日韩亚洲欧美中文高清在线| 麻豆传传媒久久久爱| 亚洲 欧美 偷自乱 图片| 国产精品制服| 国产无遮挡又黄又爽动态图| 亚洲国产欧美在线人成app|