在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse Acid sphingomyelinase-like phosphodiesterase 3b (Smpdl3b)

In Stock
  • 中文名稱:
    小鼠Smpdl3b重組蛋白
  • 貨號:
    CSB-EP021850MO
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    Smpdl3b
  • Uniprot No.:
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length of Mature Protein
  • 來源:
    E.coli
  • 分子量:
    57.1 kDa
  • 表達區域:
    19-456aa
  • 氨基酸序列
    QLGRFWHISDLHLDPNYTVSKDPLQVCPSAGSQPVLNAGPWGDYLCDSPWALINSSLYAMKEIEPKPDFILWTGDDTPHVPNESLGEAAVLAIVERLTNLIKEVFPDTKVYAALGNHDFHPKNQFPAQSNRIYNQVAELWRPWLSNESYALFKRGAFYSEKLPGPSRAGRVVVLNTNLYYSNNEQTAGMADPGEQFRWLGDVLSNASRDGEMVYVIGHVPPGFFEKTQNKAWFRESFNEEYLKVIQKHHRVIAGQFFGHHHTDSFRMFYDNTGAPINVMFLTPGVTPWKTTLPGVVDGANNPGIRIFEYDRATLNLKDLVTYFLNLRQANVQETPRWEQEYRLTEAYQVPDASVSSMHTALTRIASEPHILQRYYVYNSVSYNHLTCEDSCRIEHVCAIQHVAFNTYATCLHGLGAKLVPGFLLILTLLPSLHVLEVL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20°C/-80°C. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Lipid-modulating phosphodiesterase. Active on the surface of macrophages and dendritic cells and strongly influences macrophage lipid composition and membrane fluidity. Acts as a negative regulator of Toll-like receptor signaling. Has in vitro phosphodiesterase activity, but the physiological substrate is unknown. Lacks activity with phosphocholine-containing lipids, but can cleave CDP-choline, and can release phosphate from ATP and ADP (in vitro).
  • 基因功能參考文獻:
    1. These results demonstrate that radiation injury induces early cytoskeletal remodeling, down-regulation of SMPDL3b, and elevation of cellular ceramide levels. Overexpression of SMPDL3b and pretreatment with rituximab confer a radioprotective effect in cultured podocytes. PMID: 27836988
    2. Although a potential substrate for SMPDL3B is sphingomyelin, we identify other possible substrates such as CDP-choline, ATP, and ADP. PMID: 27687724
    3. our results identify the membrane-modulating enzyme SMPDL3B as a negative regulator of TLR signaling that functions at the interface of membrane biology and innate immunity. PMID: 26095358
    4. SMPDL3b may be an important modulator of podocyte function by shifting suPAR-mediated podocyte injury from a migratory phenotype to an apoptotic phenotype and that it represents a novel therapeutic glomerular disease target PMID: 24925721
  • 亞細胞定位:
    Secreted. Cell membrane; Lipid-anchor, GPI-anchor.
  • 蛋白家族:
    Acid sphingomyelinase family
  • 組織特異性:
    Macrophages and dendritic cells.
  • 數據庫鏈接:


主站蜘蛛池模板: 精品国产一区av天美传媒| 亚洲国产区男人本色| 久久久亚洲欧洲日产国码是av| 人妻另类 专区 欧美 制服| 狼群社区www中文视频| 2021麻豆剧传媒一二三区| 免费裸体无遮挡黄网站免费看| 日韩精品一区二区三区免费视频| 国产高清japanese在线播放e| 久久综合亚洲鲁鲁五月天| 成人一区二区免费中文字幕视频| 国内熟妇人妻色无码视频在线| 亚洲日韩国产精品第一页一区| 免费无码又爽又刺激高潮| 人人妻人人爽人人澡欧美一区| 九九视频麻婆豆腐在线观看| 午夜成人无码福利免费视频| 中国浓毛少妇毛茸茸| 久久精品熟女亚州av麻豆| 国产成人精品免费视频大全软件| 久久久久久久性潮| 曰韩免费无码av一区二区| 亚洲色一色噜一噜噜噜| 久久精品免费一区二区三区| 色一情一乱一伦麻豆| 日本精品一区二区三区四区| 欧美激情精品成人一区| 朋友的丰满人妻中文字幕| 亚洲中文无码永久免费| 永久免费的av片在线电影网| 久久婷婷五月综合色俺也想去| 精品国偷自产在线视频| 国产精品久久久久久无码| 精品aⅴ一区二区三区| 精品人成视频免费国产| 欧洲吸奶大片在线看| 亚洲成aⅴ人片久青草影院| 久久欧美一区二区三区性牲奴| 国产98在线 | 免费、| 欧美丰满妇大ass| 日本高清在线www3344|