在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse AT-rich interactive domain-containing protein 5A (Arid5a)

In Stock
  • 中文名稱:
    Recombinant Mouse AT-rich interactive domain-containing protein 5A(Arid5a)
  • 貨號:
    CSB-YP667554MO
  • 規(guī)格:
    ¥2208
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    Arid5a
  • Uniprot No.:
  • 別名:
    Arid5a; AT-rich interactive domain-containing protein 5A; ARID domain-containing protein 5A
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    Yeast
  • 分子量:
    65.9kDa
  • 表達區(qū)域:
    1-590aa
  • 氨基酸序列
    MAAPPAKGNTEQSEEGDLPQLPVSPKPDDEQSRSQSPTQLQDSPEAGGEQEEEQAFLVSLYKFMKERHTPIERVPHLGFKQINLWKIYKAVEKLGAYELVTGRRLWKNVYDELGGSPGSTSAATCTRRHYERLVLPYVRHLKGEDDKPLPPTKPRKQYKMAKELRGDDGTTEKLKKAKDSEERRVEQTTPGKTKSDATGQTQLPCQGSSRDSTEQLGPVSGPSPPLTGASSCPEAYKRLLSSFYCKGAHGIMSPLAKKKLLAQVSKAEALQCQEEGCRHGARSPNKDIQDSPQNLRGPAENSEHQLTPREGLQAPGGSTRMEAQVGPCPTAPMFSGCFHAYPTEVLKPVSQHPRDFFSGLKDRVLLGPPGKEEGPTTKESHLVWGGDANHPSAFHKGSTRKRSFYPKPKACWVSPMAKVPTERPGAPSPHPSSPGLGSKRGLEEEGFAHGGKKLRAVSPFLKEVDSKETGGKPAAPGLAVSCLLGPTPGPTPPEAYRGTMLRCPLNFTGSADPLKGQASLPFSPLVIPAFPAHLLATTGSSPMAASLMHFPPTPYDAVLRNRLGPASSAWHMPPVTTYAAPHFFHLNTKL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    DNA-binding protein that may regulate transcription and act as a repressor by binding to AT-rich stretches in the promoter region of target genes. May positively regulate chondrocyte-specific transcription such as of COL2A1 in collaboration with SOX9 and positively regulate histone H3 acetylation at chondrocyte-specific genes. May stimulate early-stage chondrocyte differentiation and inhibit later stage differention. Can repress ESR1-mediated transcriptional activation; proposed to act as corepressor for selective nuclear hormone receptors. As RNA-binding protein involved in the regulation of inflammatory response by stabilizing selective inflammation-related mRNAs, such as IL6, STAT3 and TBX21. Binds to stem loop structures located in the 3'UTRs of IL6, STAT3 and TBX21 mRNAs; at least for STAT3 prevents binding of ZC3H12A to the mRNA stem loop structure thus inhibiting its degradation activity. Contributes to elevated IL6 levels possibly implicated in autoimmunity processes. IL6-dependent stabilization of STAT3 mRNA may promote differentiation of naive CD4+ T-cells into T-helper Th17 cells. In CD4+ T-cells may also inhibit RORC-induced Th17 cell differentiation independently of IL6 signaling. Stabilization of TBX21 mRNA contributes to elevated interferon-gamma secretion in Th1 cells possibly implicated in the establishment of septic shock. Stabilizes TNFRSF4/OX40 mRNA by binding to the conserved stem loop structure in its 3'UTR; thereby competing with the mRNA-destabilizing functions of RC3H1 and endoribonuclease ZC3H12A.
  • 基因功能參考文獻:
    1. High Arid5a expression is associated with inflammation. PMID: 29358370
    2. Arid5a deficiency resulted in decreased levels of IFN-gamma under Th1 cell conditions, in which T-box expressed in T cells (T-bet) mRNA expression was inhibited. PMID: 27671645
    3. data showed that regulation of Arid5a by NF-kappaB and MAPK signaling is required to maintain the balance of IL-6 mRNA expression PMID: 28168301
    4. this study shows that Arid5a-deficient mice were highly refractory to bleomycin-induced lung injury PMID: 28379390
    5. T cell-intrinsic role of Arid5a on fate decisions of naive CD4(+)T cells through selective stabilization of Stat3 mRNA. PMID: 27022145
    6. Arid5a controls IL-6 mRNA stability, which contributes to elevation of IL-6 level in vivo. PMID: 23676272
    7. AT-rich interactive domain-containing protein 5a (Arid5a) cooperates with Sox9 to stimulate chondrocyte-specific transcription. PMID: 21346191

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus.
  • 組織特異性:
    Expressed in T cells (at protein level). Expressed at high levels in cartilage, heart, testis and bone.
  • 數據庫鏈接:


主站蜘蛛池模板: 巨大黑人极品videos精品| 又紧又黄的免费视频网站 | 五月综合缴情婷婷六月| 无码三级在线看中文字幕完整版| 久久精品久久精品久久39| 亚洲欧美丝袜精品久久| 亚洲色在线v中文字幕| 亚洲欧美成人一区二区在线| 国产偷窥熟女高潮精品视频| 乱码av麻豆丝袜熟女系列| 大乳丰满人妻中文字幕日本电影| 青楼妓女禁脔道具调教sm| 人妻 校园 激情 另类| 天天av天天爽无码中文| 电影内射视频免费观看| 成人午夜福利免费体验区| 少妇激情一区二区三区视频小说| 最新成年女人毛片免费基地| 337p日本大胆欧久久| 久久久久亚洲国产av麻豆| 国产精品后入内射日本在线观看| 狠狠做深爱婷婷久久综合一区| 精品日产一卡二卡| 新版天堂资源中文8在线| 国产精品久久久久野外| 久久激情日本亚洲欧洲国产中文| 亚洲.日韩.欧美另类| 水蜜桃亚洲一二三四在线| 成人午夜国产内射主播| 日本国产成人国产在线播放| 成人影院yy111111| 天天弄天天模| 欧洲熟妇色xxxxx视频| 久久综合色老色| 97久久精品人人澡人人爽| 猫咪www免费人成网站无码| 久久久久久久久久久免费精品| 青青青国产精品一区二区| 国产精品成人a区在线观看| av区无码字幕中文色| 亚洲男人的天堂av手机在线观看|