在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Mouse AT-rich interactive domain-containing protein 3A (Arid3a)

Recombinant Mouse AT-rich interactive domain-containing protein 3A (Arid3a)

  • 中文名稱：
    Recombinant Mouse AT-rich interactive domain-containing protein 3A(Arid3a)
  • 貨號：
    CSB-YP720301MO
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mouse AT-rich interactive domain-containing protein 3A(Arid3a)
  • 貨號：
    CSB-EP720301MO
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mouse AT-rich interactive domain-containing protein 3A(Arid3a)
  • 貨號：
    CSB-EP720301MO-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mouse AT-rich interactive domain-containing protein 3A(Arid3a)
  • 貨號：
    CSB-BP720301MO
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mouse AT-rich interactive domain-containing protein 3A(Arid3a)
  • 貨號：
    CSB-MP720301MO
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Arid3a
  • Uniprot No.：
  • 別名：
    Arid3a; Dri1; Dril1AT-rich interactive domain-containing protein 3A; ARID domain-containing protein 3A; B-cell regulator of IgH transcription; Bright; Dead ringer-like protein 1
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-601
  • 氨基酸序列
    MKLQAVMETL IQRQQRARQE LEARQAPPPP PPEPTGVRAR TTMTDEDREP ENARMHRTQM AALAAMRAAA AGLGHPSSPG GSEDGPPISG DEDTAREGTL SSPALHGSVL EGAGHAEGDR HLMDVGSDDD DTKSKWEEQE LEELGEEEEE EEEEDDFEEE EEEEEGLGPP ESASLGTAGL FTRKAPPAQA FRGDGGPRML SGPERLGPGP AHPSHMASQM PPPDHGDWTF EEQFKQLYEL DADPKRKEFL DDLFSFMQKR GTPVNRIPIM AKQVLDLFML YVLVTEKGGL VEVINKKLWR EITKGLNLPT SITSAAFTLR TQYMKYLYPY ECERRGLSSP NELQAAIDSN RREGRRQSFG GSLFAYSPSG AHSMLPSPKL PVTPLGLAAS TNGSSITPAP KIKKEEDSAI PITVPGRLPV SLAGHPVVAA QAAAVQAAAA QAAVAAQAAA LEQLREKLES TEPPEKKMAL VADEQQRLMQ RAVQQSFLAM TAQLPMNIRI NSQASESRQD SAVSLTSANG SNSISMSVEM NGIVYTGVLF AQPPPPTAPS APGKGGVSSI GTNTTTGSRT GASGSTVSGG QVGLPGVSTP TMSSTSNNSL P
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription factor involved in B-cell differentiation. Binds a VH promoter proximal site necessary for induced mu-heavy-chain transcription. Binds the minor groove of a restricted ATC sequence that is sufficient for nuclear matrix association. This sequence motif is present in matrix-associating regions (MARS) proximal to the promoter and flanking E mu. Activates E mu-driven transcription by binding these sites. May be involved in the control of cell cycle progression by the RB1/E2F1 pathway.
  • 基因功能參考文獻：
    1. Our data show that signals provided by thymic epithelial cells control thymic B cell development by up-regulating Let-7, suppressing Arid3a expression in intrathymic progenitor B cells to limit their proliferation during the neonatal to adult transition. PMID: 29462197
    2. ARID3A is required for normal murine trophoblast development in vivo. The results reveal an essential, conserved function for ARID3A in mammalian placental development through regulation of both intrinsic and extrinsic developmental programs. PMID: 27965054
    3. identify the Arid3a transcription factor as a key target of Let-7, whose ectopic expression is sufficient to induce B-1 development in adult pro-B cells and whose silencing by knockdown blocks B-1 development in fetal pro-B cells. PMID: 25753579
    4. These data reveal new functions for ARID3a in early hematopoiesis and suggest that knowledge regarding ARID3a levels in HSPCs could be informative for applications requiring transplantation of those cells. PMID: 25535283
    5. identify Arid3a as a critical regulator of TE and placental development through execution of the commitment and differentiation phases of the first cell fate decision PMID: 25319825
    6. These data suggest a novel role for Bright in the normal development of mature B cell subsets and in autoantibody production PMID: 21963220
    7. these results place Bright/Arid3a on a select list of transcriptional regulators required to program both hematopoietic stem cell and lineage-specific differentiation. PMID: 21199920
    8. Id1 inhibited DNA binding by Dril1, and the two proteins co-localized in vitro and in vivo, providing a potential mechanism for suppression of fibrosis by Id1 through inhibition of the profibrotic function of Dril1.(Dril1) PMID: 18583319
    9. Bright/ARID3a inhibition causes increased developmental plasticity in mouse and human cells. PMID: 20680960
    10. Variations in Bright binding and matrix attachment region activity contribute to localized control of accessibility and therefore nonrandom gene use during V(D)J recombination. PMID: 12193717
    11. identify regions within Bright that are required for the DNA binding activity of Bright and for its function as a transcription factor PMID: 15456761
    12. The ability of Bright to enhance immunoglobulin transcription critically requires functional Bruton's tyrosine kinase . PMID: 15743806
    13. For IgH transactivation, Bright binds to nuclear matrix association regions.Bright actively shuttles between the nucleus and the cytoplasm, regulation of Bright's cellular localization appears to be required for its function. PMID: 16507996
    14. Bright functions in a subset of Bruton's tyrosine kinase-dependent pathways in vivo, particularly those responses dominated by B1 B cells. PMID: 18981111
    15. A palmitoylated pool of Bright is diverted to lipid rafts of resting B cells where it associates with signalosome components. PMID: 19214191

    顯示更多

    收起更多

  • 亞細胞定位：
    Nucleus. Cytoplasm. Note=Shuttles between nucleus and cytoplasm.
  • 組織特異性：
    B-cell specific in the adult. Expressed in B-cell progenitors, down-regulated in the immature B-cell stage, and is up-regulated again at later stages of B-lymphocyte differentiation.
  • 數據庫鏈接：


主站蜘蛛池模板： 精品国精品无码自拍自在线| 一本一久本久a久久精品综合 | 日产精品久久久久久久性色| 无码av无码天堂资源网| 亚洲精品无码av黄瓜影视| 99热精品国自产拍天天拍| 国产精品免费久久久久软件| 成人精品一区日本无码网| 无码免费一区二区三区免费播放| 欧洲无码精品a码无人区| 国产女人抽搐喷浆视频| 久久综合九色综合网站| 国产伦子沙发午休系列资源曝光| 亚洲日韩在线a视频在线观看| 2022国产日产欧产精品| 国产无遮挡aaa片爽爽| 亚洲成在人线av无码| 国产麻豆一精品av一免费软件| 无码国产成人午夜在线观看| 西西人体www大胆高清视频| 一群黑人大战亚裔女在线播放| 免费无码av片在线观看网址| 少妇被又大又粗又爽毛片久久黑人 | 夜夜爱夜鲁夜鲁很鲁| 一个人看的www视频免费观看| 大肉大捧一进一出好爽app| 国内永久福利在线视频图片| 国产极品久久久久极品| 99久久无码一区人妻| 日韩精品无码一区二区忘忧草| 777米奇色狠狠俺去啦奇米77| 狠狠躁天天躁中文字幕| 8av国产精品爽爽ⅴa在线观看| 欧美变态另类牲交| 与子敌伦刺激对白播放| 中文字幕在线观看亚洲日韩| 久久中文字幕无码中文字幕有码| 又色又爽又黄高潮的免费视频| 午夜成人理论福利片| 国产精品亚洲а∨天堂网| 久久国产亚洲精品无码|