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  4. Recombinant Mouse 80 kDa MCM3-associated protein (Mcm3ap), partial

Recombinant Mouse 80 kDa MCM3-associated protein (Mcm3ap), partial

  • 中文名稱：
    小鼠Mcm3ap重組蛋白
  • 貨號：
    CSB-YP895755MO
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    小鼠Mcm3ap重組蛋白
  • 貨號：
    CSB-EP895755MO
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    小鼠Mcm3ap重組蛋白
  • 貨號：
    CSB-EP895755MO-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    小鼠Mcm3ap重組蛋白
  • 貨號：
    CSB-BP895755MO
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    小鼠Mcm3ap重組蛋白
  • 貨號：
    CSB-MP895755MO
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    Mcm3ap
  • Uniprot No.：
  • 別名：
    Mcm3ap; Ganp; Map80; Germinal-center associated nuclear protein; GANP; EC 2.3.1.48; GC-associated DNA primase
  • 種屬：
    Mus musculus (Mouse)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores. Through the acetylation of histones, affects the assembly of nucleosomes at immunoglobulin variable region genes and promotes the recruitment and positioning of transcription complex to favor DNA cytosine deaminase AICDA/AID targeting, hence promoting somatic hypermutations.
  • 基因功能參考文獻：
    1. GANP works to maintain antibody structure by reducing drastic changes in the IgV framework regions in affinity maturation PMID: 28541550
    2. These results indicated that the GANP protein is associated with breast cancer resistance. PMID: 26749495
    3. GANP plays a positive role in IgV region diversification of DT40 B cells in a nonhomologous end joining-proficient state. DNA-PKcs physically interacts with GANP, and this interaction is dissociated by dsDNA breaks PMID: 24808370
    4. GANP-mediated chromatin modification promotes transcription complex recruitment and positioning at immunoglobulin variable loci to favour AID targeting. PMID: 23652018
    5. GANP may serve as an essential link required to transport AID to B-cell nuclei and to target AID to actively transcribed IgV regions PMID: 20507984
    6. interaction with MCM3 is associated with a novel phosphatase component G5PR PMID: 12167160
    7. GANP(hi)plasma-like cells appear in lymph nodes of autoimmune mice during aging PMID: 12791315
    8. role in generation or maintenance of B cells with high-affinity B cell antigen receptors during the maturation in germinal centers PMID: 14715907
    9. Decreased expression of germinal center-associated protein (GANP) in Lyn kinase-deficient mice suggests that Lyn controls the formation and proliferation of germinal centers via GANP. PMID: 15034025
    10. GANP is involved in V region alteration generating high-affinity Ab. PMID: 15814669
    11. GANP has a critical role in suppression of DNA hyper-recombination in mammalian cells PMID: 17903179

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  • 亞細胞定位：
    Cytoplasm. Nucleus. Nucleus envelope. Nucleus, nuclear pore complex. Nucleus, nucleoplasm. Chromosome.
  • 蛋白家族：
    SAC3 family
  • 組織特異性：
    Expressed at low levels in lymphoid organs, including thymus, spleen and lymph nodes. Up-regulated in stimulated B-cells in spleen and Peyer's patch germinal centers (at protein level).
  • 數據庫鏈接：


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