在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Mouse 14-3-3 protein beta/alpha (Ywhab)

In Stock
  • 中文名稱:
    小鼠Ywhab重組蛋白
  • 貨號:
    CSB-EP875120MO
  • 規格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
  • Uniprot No.:
  • 別名:
    Ywhab; 14-3-3 protein beta/alpha; Protein kinase C inhibitor protein 1; KCIP-1) [Cleaved into: 14-3-3 protein beta/alpha; N-terminally processed]
  • 種屬:
    Mus musculus (Mouse)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    33.6 kDa
  • 表達區域:
    1-246aa
  • 氨基酸序列
    MTMDKSELVQKAKLAEQAERYDDMAAAMKAVTEQGHELSNEERNLLSVAYKNVVGARRSSWRVISSIEQKTERNEKKQQMGKEYREKIEAELQDICNDVLELLDKYLILNATQAESKVFYLKMKGDYFRYLSEVASGENKQTTVSNSQQAYQEAFEISKKEMQPTHPIRLGLALNFSVFYYEILNSPEKACSLAKTAFDEAIAELDTLNEESYKDSTLIMQLLRDNLTLWTSENQGDEGDAGEGEN
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Negative regulator of osteogenesis. Blocks the nuclear translocation of the phosphorylated form (by AKT1) of SRPK2 and antagonizes its stimulatory effect on cyclin D1 expression resulting in blockage of neuronal apoptosis elicited by SRPK2. Negative regulator of signaling cascades that mediate activation of MAP kinases via AKAP13.
  • 基因功能參考文獻:
    1. Data indicate 14-3-3 beta protein as an interacting partner of type 1 cannabinoid receptor (CB1R). PMID: 25002257
    2. the novel protein interaction mode in the 14-3-3beta.ChREBP alpha2 complex. PMID: 23086940
    3. Studies suggest that insulin may modulate the cellular function of lipin-1 by regulating its subcellular localization through interactions with 14-3-3 proteins. PMID: 19955570
    4. 14-3-3 participates in the intracellular trafficking of IRS-1 PMID: 11875115
    5. The transcription start site was identified and the polyadenylation signals (AATAAA) were found in exon 2 of the mouse gene. In the 5'-upstream sequence, we found three cis elements including a CRE sequence, a TATA box-like sequence, and a C/EBP element. PMID: 12008017
    6. PRAS40 is a novel substrate of Akt, the phosphorylation of which leads to the binding of this protein to 14-3-3. PMID: 12524439
    7. 14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity PMID: 12618428
    8. 14-3-3beta gene plays a pivotal role in abnormal growth of tumor cells in vitro and in vivo. PMID: 12896901
    9. These results indicate for the first time that 14-3-3 protein plays a critical anti-apoptotic role in diabetic myocardium by inhibiting the JNK pathway. PMID: 15240115
    10. aldosterone increases the expression of 14-3-3beta, which interacts with phospho-Nedd4-2 to block its interaction with ENaC, thus enhancing sodium absorption by increasing apical membrane ENaC density PMID: 16613846
    11. Cbl-b deficiency. Cbl-b deficiency resulted in increased phosphorylation of T758 in the beta2-chain of LFA-1 and thereby in enhanced association of 14-3-3beta protein with the beta2-chain PMID: 18239087
    12. Akt1 is necessary for the growth factor stimulated activation of 14-3-3beta-Rac1-p21 activated kinase (Pak) pathway in endothelial cells and fibroblasts. PMID: 18853424

    顯示更多

    收起更多

  • 亞細胞定位:
    Cytoplasm. Melanosome.
  • 蛋白家族:
    14-3-3 family
  • 數據庫鏈接:


主站蜘蛛池模板: 日本熟妇色xxxxxhd| 顶级欧美熟妇xx| 无码无遮挡又大又爽又黄的视频| 好男人日本社区www| 少妇被粗大的猛烈进出动视频| 国产成人精品免高潮在线观看| 欧美激情性做爰免费视频 | 精品国产午夜福利精品推荐| 波多野结衣一区二区三区av高清| 免费观看黄网站在线播放| 久久久精品人妻一区亚美研究所| 国产在线高清理伦片a| 99久久99视频只有精品| 69综合精品国产二区无码| 艳妇乳肉豪妇荡乳xxx| 女人张开双腿让男人猛桶| 亚洲国产精品自在拍在线播放蜜臀 | 午夜精品射精入后重之免费观看 | 亚洲色大成网站在线| 国产成人愉拍免费视频| 国内精品久久久久久tv| 日日摸天天摸爽爽狠狠97| 国产又黄又潮娇喘视频在线观看 | 亚洲一区二区三区无码av| 99国产精品无码| 18禁裸乳无遮挡啪啪无码免费| 国产无遮挡又黄又爽在线视频 | 精品亚洲欧美无人区乱码| 久久久久人妻一区精品色欧美 | 欧美成人免费全部| 日本一区二区三区不卡免费| 好男人社区www在线观看| 老外和中国女人毛片免费视频| 18禁黄无遮挡网站免费| 亚洲成av人片天堂网九九| 国产天堂亚洲国产碰碰| 精品一区二区三区东京热| 亚洲aⅴ在线无码播放毛片一线天| 亚洲欧美日韩一区二区| 无码人妻啪啪一区二区| 国产亚洲精品美女在线|