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  4. Recombinant Mesobuthus martensii Beta-insect depressant toxin BmKIT2

Recombinant Mesobuthus martensii Beta-insect depressant toxin BmKIT2

  • 中文名稱：
    Recombinant Mesobuthus martensii Beta-insect depressant toxin BmKIT2
  • 貨號：
    CSB-YP304746MRE
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mesobuthus martensii Beta-insect depressant toxin BmKIT2
  • 貨號：
    CSB-EP304746MRE
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mesobuthus martensii Beta-insect depressant toxin BmKIT2
  • 貨號：
    CSB-EP304746MRE-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mesobuthus martensii Beta-insect depressant toxin BmKIT2
  • 貨號：
    CSB-BP304746MRE
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mesobuthus martensii Beta-insect depressant toxin BmKIT2
  • 貨號：
    CSB-MP304746MRE
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 別名：
    ; Beta-insect depressant toxin BmKIT2; Depressant insect toxin BmK IT2
  • 種屬：
    Mesobuthus martensii (Manchurian scorpion) (Buthus martensii)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-61
  • 氨基酸序列
    DGYIKGKSGC RVACLIGNQG CLKDCRAYGA SYGYCWTWGL ACWCEGLPDN KTWKSESNTC G
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    On insects, this depressant beta-toxins cause a transient contraction paralysis followed by a slow flaccid paralysis. They bind voltage-independently at site-4 of sodium channels (Nav) and shift the voltage of activation toward more negative potentials thereby affecting sodium channel activation and promoting spontaneous and repetitive firing. This toxin is active against insects and mammals. It is capable of binding to not only cockroach neuronal membranes, but also rat cerebrocortical and hippocampal synaptosomes. This toxin also has potent peripheral and central suppressive effects on rat nociceptive spontaneous responses, thermal hyperalgesia and spinal c-Fos expression induced by formalin and carrageenan, which may be derived from its modulation on the activity of sodium channels of the neurons. Administration of BmKIT2 into rat brain can also suppress the epileptic seizures significantly.
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Long (4 C-C) scorpion toxin superfamily, Sodium channel inhibitor family, Beta subfamily
  • 組織特異性：
    Expressed by the venom gland.


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