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  4. Recombinant Mesobuthus eupeus Potassium channel toxin gamma-KTx 2.1

Recombinant Mesobuthus eupeus Potassium channel toxin gamma-KTx 2.1

  • 中文名稱：
    Recombinant Mesobuthus eupeus Potassium channel toxin gamma-KTx 2.1
  • 貨號：
    CSB-YP859000MRD
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Mesobuthus eupeus Potassium channel toxin gamma-KTx 2.1
  • 貨號：
    CSB-EP859000MRD
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Mesobuthus eupeus Potassium channel toxin gamma-KTx 2.1
  • 貨號：
    CSB-EP859000MRD-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Mesobuthus eupeus Potassium channel toxin gamma-KTx 2.1
  • 貨號：
    CSB-BP859000MRD
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Mesobuthus eupeus Potassium channel toxin gamma-KTx 2.1
  • 貨號：
    CSB-MP859000MRD
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 別名：
    Potassium channel toxin gamma-KTx 2.1; Neurotoxin BeKm-1; BeKm1
  • 種屬：
    Mesobuthus eupeus (Lesser Asian scorpion) (Buthus eupeus)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區(qū)域：
    22-57
  • 氨基酸序列
    RPTDIKCSE SYQCFPVCKS RFGKTNGRCV NGFCDCF
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 668
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Blocks human and/or rat Kv11.1/KCNH2/ERG1, Kv11.2/KCNH6/ERG2 and Kv11.3/KCNH7/ERG3 by binding to channel outer vestibule (S5P domain) with a 1:1 stoichiometry. Inhibition data are the following: hERG1 (reversible, Kd=7.7 nM, IC(50)=3.3 nM, IC(50)=11.9 nM), rERG1 (reversible, Kd=19 nM), hERG2 (reversible, Kd=77 nM), rERG2 (irreversible, Kd=4.2 nM), hERG3 (reversible, Kd=11.5 nM) and rERG3 (reversible, Kd=747 nM) potassium channels. Has also a minimal effect on rat ELK1/KCNH4 potassium channels (9% inhibition at 100 nM). Both this toxin and CnErgTx1 (AC Q86QT3) share mechanism of action and have overlapping binding sites on ERG1. The potency of these two toxins is not affected by elevating potassium ion concentration from 2 to 98 mM. In addition, at high toxin concentrations, block of ERG1 macroscopic currents by these two toxins is incomplete (88%). The blockade by this toxin is preferentially closed channel state-dependent, with a component of open, but not inactive state-dependent blockade. This toxin produces a concentration-dependent prolongation of QTc in the isolated rabbit heart (16.3% at 100 nM).
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Short scorpion toxin superfamily, Potassium channel inhibitor family, Gamma-KTx 2 subfamily
  • 組織特異性：
    Expressed by the venom gland.


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