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  4. Recombinant Loxosceles intermedia Sphingomyelin phosphodiesterase D LiSicTox-alphaIA1bi

Recombinant Loxosceles intermedia Sphingomyelin phosphodiesterase D LiSicTox-alphaIA1bi

  • 中文名稱：
    Recombinant Loxosceles intermedia Sphingomyelin phosphodiesterase D LiSicTox-alphaIA1bi
  • 貨號：
    CSB-YP317164LRA
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Loxosceles intermedia Sphingomyelin phosphodiesterase D LiSicTox-alphaIA1bi
  • 貨號：
    CSB-EP317164LRA
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Loxosceles intermedia Sphingomyelin phosphodiesterase D LiSicTox-alphaIA1bi
  • 貨號：
    CSB-EP317164LRA-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Loxosceles intermedia Sphingomyelin phosphodiesterase D LiSicTox-alphaIA1bi
  • 貨號：
    CSB-BP317164LRA
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Loxosceles intermedia Sphingomyelin phosphodiesterase D LiSicTox-alphaIA1bi
  • 貨號：
    CSB-MP317164LRA
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 別名：
    ; Dermonecrotic toxin LiSicTox-alphaIA1bi; EC 4.6.1.-; LiD1; LiP1; P1; Phospholipase D; PLD; Sphingomyelin phosphodiesterase D 1; SMD 1; SMase D 1; Sphingomyelinase D 1; recLiD1
  • 種屬：
    Loxosceles intermedia (Spider)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    27-306
  • 氨基酸序列
    AGNR RPIWIMGHMV NAIGQIDEFV NLGANSIETD VSFDDNANPE YTYHGIPCDC GRNCKKYENF NDFLKGLRSA TTPGNSKYQE KLVLVVFDLK TGSLYDNQAN DAGKKLAKNL LQHYWNNGNN GGRAYIVLSI PDLNHYPLIK GFKDQLTKDG HPELMEKVGH DFSGNDDIGD VGKAYKKAGI TGHIWQSDGI TNCLPRGLSR VNAAVANRDS ANGFINKVYY WTVDKRSTTR DALDAGVDGI MTNYPDVITD VLNEAAYKKK FRVATYDDNP WVTFKK
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Dermonecrotic toxins cleave the phosphodiester linkage between the phosphate and headgroup of certain phospholipids (sphingolipid and lysolipid substrates), forming an alcohol (often choline) and a cyclic phosphate. This toxin acts on sphingomyelin (SM). The level of enzymatic activity is high according to Tambourgi and colleagues or low according to Felicori and colleagues. It may also act on ceramide phosphoethanolamine (CPE), lysophosphatidylcholine (LPC) and lysophosphatidylethanolamine (LPE), but not on lysophosphatidylserine (LPS), and lysophosphatidylglycerol (LPG). It acts by transphosphatidylation, releasing exclusively cyclic phosphate products as second products. It induces complement-dependent hemolysis, dermonecrosis, vascular permeability and platelet aggregation. Both C5a and the membrane attack complex may play a role in the induction of dermonecrosis. MMP-9 and MMP-2 produced by skin fibroblasts can also contribute to proteolytic tissue destruction.
  • 亞細胞定位：
    Secreted.
  • 蛋白家族：
    Arthropod phospholipase D family, Class II subfamily
  • 組織特異性：
    Expressed by the venom gland.


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