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  4. Recombinant Leucine-rich repeat serine/threonine-protein kinase 1 (lrk-1), partial

Recombinant Leucine-rich repeat serine/threonine-protein kinase 1 (lrk-1), partial

  • 中文名稱：
    秀麗隱桿線蟲lrk-1重組蛋白
  • 貨號：
    CSB-YP883321CXY
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲lrk-1重組蛋白
  • 貨號：
    CSB-EP883321CXY
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲lrk-1重組蛋白
  • 貨號：
    CSB-EP883321CXY-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲lrk-1重組蛋白
  • 貨號：
    CSB-BP883321CXY
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    秀麗隱桿線蟲lrk-1重組蛋白
  • 貨號：
    CSB-MP883321CXY
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    lrk-1
  • Uniprot No.：
  • 別名：
    lrk-1; T27C10.6; Leucine-rich repeat serine/threonine-protein kinase 1; EC 2.7.11.1; Leucine-rich repeats; ras-like domain; kinase protein 1; PARK8-related kinase
  • 種屬：
    Caenorhabditis elegans
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Determines polarized sorting of synaptic vesicle (SV) proteins to the axons by excluding SV proteins from the dendrite-specific transport machinery in the Golgi. Role in stress response. Appears to antagonize the effects of pink-1 both in the regulation of axon guidance and stress response.
  • 基因功能參考文獻：
    1. LRRK2 functions together with a second Parkinson's disease-associated gene, RAB7L1, within an evolutionarily conserved genetic module in diverse cellular contexts. PMID: 27424887
    2. Study investigated the role of UNC-23 and HSP-1 on LRK-1 function in C. elegans; results suggest that the UNC-23-HSP-1 chaperone complex regulates LRK-1 localization to the Golgi apparatus and consequently determines the polarized sorting of synaptic vesicle proteins to the axons. PMID: 26853528
    3. Lack of Grx1 homolog exacerbates LRRK2-mediated dopaminergic neurodegeneration in Caenorhabditis elegans. PMID: 25355420
    4. Findings establish a critical functional link between LRRK2 and ER stress. PMID: 21857923
    5. Study identified a novel protein kinase LRK-1, a C. elegans homolog of the familial Parkinsonism gene PARK8/LRRK2 that is required for polarized localization of synaptic vesicle proteins. PMID: 17346966
    6. LRRK2 can regulate the mitochondrial physiology of Caenorhabditis elegans, possibly via the worm lrk-1 pathway. PMID: 18322385
    7. Due to the similarity of the C. elegans proteins to human LRRK2 and PINK1, we suggest a common role of both factors in cellular functions including stress response and regulation of neurite outgrowth PMID: 19251702

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  • 亞細胞定位：
    Golgi apparatus.
  • 蛋白家族：
    Protein kinase superfamily, TKL Ser/Thr protein kinase family, ROCO subfamily
  • 組織特異性：
    Expressed in cell bodies, but not in dendritic or axonal processes, of adult head neurons. Also present in non-neuronal tissues, such as the body wall musculature and the epithelial cells of the nematode vulva.
  • 數據庫鏈接：

    KEGG: cel:CELE_T27C10.6

    STRING: 6239.T27C10.6

    UniGene: Cel.20322



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