在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant JC polyomavirus Major capsid protein VP1

Recombinant JC polyomavirus Major capsid protein VP1

  • 中文名稱：
    Recombinant JC polyomavirus Major capsid protein VP1
  • 貨號：
    CSB-YP355946JAK
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant JC polyomavirus Major capsid protein VP1
  • 貨號：
    CSB-EP355946JAK
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant JC polyomavirus Major capsid protein VP1
  • 貨號：
    CSB-EP355946JAK-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant JC polyomavirus Major capsid protein VP1
  • 貨號：
    CSB-BP355946JAK
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant JC polyomavirus Major capsid protein VP1
  • 貨號：
    CSB-MP355946JAK
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    N/A
  • Uniprot No.：
  • 別名：
    ; Major capsid protein VP1; Major structural protein VP1
  • 種屬：
    JC polyomavirus (JCPyV) (JCV)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-354
  • 氨基酸序列
    MAPTKRKGER KDPVQVPKLL IRGGVEVLEV KTGVDSITEV ECFLTPEMGD PDEHLRGFSK SISISDTFES DSPNRDMLPC YSVARIPLPN LNEDLTCGNI LMWEAVTLKT EVIGVTSLMN VHSNGQATHD NGAGKPVQGT SFHFFSVGGE ALELQGVLFN YRTKYPDGTI FPKNATVQSQ VMNTEHKAYL DKNKAYPVEC WVPDPTRNEN TRYFGTLTGG ENVPPVLHIT NTATTVLLDE FGVGPLCKGD NLYLSAVDVC GMFTNRSGSQ QWRGLSRYFK VQLRKRRVKN PYPISFLLTD LINRRTPRVD GQPMYGMDAQ VEEVRVFEGT EELPGDPDMM RYVDKYGQLQ TKML
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with a N-linked glycoprotein containing terminal alpha(2-6)-linked sialic acids on the cell surface to provide virion attachment to target cell. The serotonergic receptor 5HT2AR also acts as a cellular receptor for JCV on human glial cells. Once attached, the virions enter predominantly by a ligand-inducible clathrin-dependent pathway and traffic to the ER. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA at nuclear domains called promyelocytic leukemia (PML) bodies, and participates in rearranging nucleosomes around the viral DNA.
  • 基因功能參考文獻：
    1. All viral populations were characterized by rearrangements within the noncoding regulatory region (NCCR) and 1 point mutation, S267L in the VP1 gene, suggestive of neurotropic strains. One patient with Progressive multifocal leukoencephalopathy (PML) had a single neurotropic strain with rearranged noncoding regulatory region (NCCR), and 1 patient had a single strain with small NCCR alterations. PMID: 28453853
    2. found that deletion of nucleotides 376-396 results in decreased levels of viral DNA replication and a lack of VP1 expression. PMID: 25142442
    3. Synthetic antibodies and peptides recognizing progressive multifocal leukoencephalopathy-specific point mutations in polyomavirus JC capsid viral protein 1. PMID: 25879139
    4. These data show that capsid proteins of Mad-1 and WT3 JC Polyomavirus can both engage alpha2,6-linked sialic acid on the lactoseries tetrasaccharide c as well as multiple sialylated gangliosides. PMID: 25855729
    5. This study demonstrated that the 5-fold VP1 pore is an important structural feature of JC polyomavirus and that minor modifications to this structure have significant impacts on infectious entry. PMID: 25609820
    6. C80 of JCV Vp1 is required for Vp1 stability and pentamer formation, and C247 is involved in capsid assembly in the nucleus PMID: 24130786
    7. These results demonstrate that viruses from progressive multifocal leukoencephalopathy patients with single point mutations in VP1 disrupt binding to sialic acid motifs and render these viruses noninfectious. PMID: 23760462
    8. VP1 C terminus mutants were replication-competent and remains stable overtime in vitro. PMID: 21940415
    9. mutations of JCV VP1 might favor progressive multifocal leukoencephalopathy onset; VP1 substitutions may favor JCV brain invasion by abrogation of sialic acid binding with peripheral cells while maintaining sialic acid-independent binding with brain cells PMID: 21628664
    10. model of the interaction between VP1 and the sialic acid component of the human JCV receptor PMID: 15347668
    11. frequent amino acid substitutions in the outer loops of VP1 of JCPyV associated with progressive multifocal leukoencephalopathy (PML) PMID: 15958683
    12. A unique deletion was found in the C terminus may be instrumental in facilitating entry or replication of JCV into granule cell neurons. PMID: 16894191
    13. A possible role for merkel cells Polyomavirus as an etiologic agent in the carcinogenesis of merkel cell carcinoma. PMID: 18593898
    14. JCV VP1 loop mutations are associated with a favorable prognosis for PML PMID: 19043822
    15. several amino acids on surface of VP1 display accelerated evolution in viral sequences isolated from progressive multifocal leukoencephalopathy patients but not healthy subjects; evidence that some mutations are involved in binding of sialic acid PMID: 19197354

    顯示更多

    收起更多

  • 亞細胞定位：
    Virion. Host nucleus.
  • 蛋白家族：
    Polyomaviruses coat protein VP1 family
  • 數據庫鏈接：

    KEGG: vg:1489518



主站蜘蛛池模板： 欧美日本特级婬片视频| 国产手机在线国内精品| av天堂永久资源网| 一边捏奶头一边啪高潮视频| 婷婷五月日韩av永久免费| 国产精品三级av三级av三级| 亚洲精品无码久久久| 吸咬奶头狂揉60分钟视频| 国产av天堂无码一区二区三区| 国产在线观看精品一区二区三区| 大伊香蕉在线精品视频75| 天天爽夜夜爽人人爽88| 四川丰满少妇被弄到高潮| 强奷人妻日本中文字幕| 小雪好紧好滑好湿好爽视频| 97精品国自产在线偷拍| 天天天狠天天碰天天爱| 免费人成在线观看网站| 中文在线最新版天堂| 国产精品人妻系列21p| 波多野成人无码精品电影| 国产成人久久精品二区三区| 精品欧美乱码久久久久久1区2区 | 熟女性饥渴一区二区三区| 精品国产乱码久久久久久郑州公司| 怡春院国产精品视频| 日韩a人毛片精品无人区乱码| 开心五月激情综合婷婷色| 国产精品欧美久久久久久日本一道| 风流老熟女一区二区三区| av高清无码 在线播放| 欧美日韩中文在线字幕视频| 欧美人妻一区二区三区| 最新系列国产专区|亚洲国产| 美女扒开腿让男人桶爽app免费看 精品国产免费人成电影在线看 | 国产精品久久久| 日韩人妻无码精品免费shipin| 国产乱人伦偷精品视频免| 老子影院午夜伦手机不四虎卡| 久久人人爽天天玩人人妻精品| 久久久亚洲欧洲日产国码αv|