在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human parvovirus B19 Non-capsid protein NS-1 (NS1), partial

In Stock
  • 中文名稱:
    Recombinant Human parvovirus B19 Non-capsid protein NS-1(NS1),partial
  • 貨號:
    CSB-EP357083HPM
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP357083HPM could indicate that this peptide derived from E.coli-expressed Human parvovirus B19 (isolate AU) (HPV B19) NS1.
    • Based on the SEQUEST from database of E.coli host and target protein, the LC-MS/MS Analysis result of CSB-EP357083HPM could indicate that this peptide derived from E.coli-expressed Human parvovirus B19 (isolate AU) (HPV B19) NS1.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    NS1
  • Uniprot No.:
  • 別名:
    NS1; Initiator protein NS1; NS1; EC 3.1.21.-; EC 3.6.4.12; NCVP1; Non-capsid protein NS-1; Non-structural protein 1; Non-structural protein NS1
  • 種屬:
    Human parvovirus B19 (isolate AU) (HPV B19)
  • 蛋白長度:
    Partial
  • 來源:
    E.coli
  • 分子量:
    44.6kDa
  • 表達區域:
    1-255aa
  • 氨基酸序列
    MELFRGVLQVSSNVLDCANDNWWCSLLDLDTSDWEPLTHTNRLMAIYLSSVASKLDFTGGPLAGCLYFFQVECNKFEEGYHIHVVTGGPGLNPRNLTVCVEGLFNNVLYHLVTENVKLKFLPGMTTKGKYFRDGEQFIENYLMKKIPLNVVWCVTNIDGYIDTCISATFRRGACHAKKPRITTAINDTSSDAGESSGTGAEVVPFNGKGTKASIKFQTMVNWLCENRVFTEDKWKLVDFNQYTLLSSSHSGSFQI
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產品描述:

    The production of this recombinant HPV B19 NS1 protein is just like all recombinant proteins. The process involved transfecting E.coli cells with DNA vector containing the template of recombinant DNA. The E.coli cells containing the template were then cultured so that they could transcribe and translate the NS1 protein. N-terminal 6xHis-SUMO tag was used in the process. The purity is 0.9 determined by SDS-PAGE.

    The non-structural protein 1 (NS1) of human parvovirus B19 plays a critical role in viral DNA replication, which performs many diferent functions during the virus life cycle. NS1 of parvovirus B19 induces cell death by apoptosis in at least erythroid-lineage cells by a pathway that involves caspase 3, whose activation may be a key event during NS1-induced cell death. Some studies showed that have shown that NS1 initiates apoptosis by activating caspase 3 (but not caspase 1) in a manner which is deferent from the IL-6 activation pathway. The cytotoxicity of NS1 in such cells results from chromosomal DNA damage caused by the DNA-nicking and DNA-attaching activities of NS1. Studies have been shown NS1 covalently binds to cellular DNA and is modiied by PARP (Poly ADP ribose polymerase), an enzyme involved in repairing single-stranded DNA nicks.

  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Multifunctional protein essential for viral DNA replication, which cooperatively interacts with the viral DNA origin of replication and transactivates several promoters including the viral p6 promoter. Binds the origin of replication and performs an endonucleolytic nick within a conserved sequence in the viral genome, thereby initiating the rolling circle replication (RCR). Participates in the transcriptional regulation the viral p6 promoter that regulates all viral transcripts and the cellular CDN1A or IL6 promoters. Transactivates several host promoters some of which induce the S cell cycle phase for the production of host replicative proteins. Upregulates the expression of host E2F4 and E2F5 and interacts with both these factors thereby inhibiting the host cell cycle G2/M transition. This arrest promotes apoptosis for viral release.
  • 亞細胞定位:
    Host nucleus.
  • 蛋白家族:
    Parvoviruses non-capsid protein family


主站蜘蛛池模板: 大地资源网第二页免费观看| 纯肉无遮挡h肉动漫在线观看国产| 亚洲男人综合久久综合天堂| 十八禁视频在线观看免费无码无遮挡骂过| 综合激情五月综合激情五月激情1| 欧美日产国产精品日产| 无码国产精品一区二区免费模式| 人妻色综合网站| 成人网站免费大全日韩国产| 国产在线一区二区在线视频 | 试看120分钟做受小视频| 青娱乐极品视觉盛宴av| 国精品无码av人妻受辱系| 麻豆国产av丝袜白领传媒| 久久综合九色综合网站| 国产熟妇勾子乱视频| 国产又黄又潮娇喘视频在线观看| 国产成人一区二区三区免费视频| 欧美xxxx做受视频| 欧美又大又硬又粗bbbbb| √8天堂资源地址中文在线| 久久久噜噜噜久久熟女色| 亚洲精品国偷拍自产在线麻豆| 欧美奶涨边摸边做爰视频| 欧美激情一区二区三区| 亚洲男人综合久久综合天堂| 丰满少妇人妻无码| 中国女人内谢69xxxxxa片| 五月婷六月婷婷俺也去| 亚洲国产成人久久一区| 国产涩涩视频在线观看| 尤物网址在线观看| 无码人妻一区二区中文| 午夜成人无码福利免费视频| 国产情侣真实露脸在线| 一本大道久久东京热av| 中文字幕无线码成人免费看| 亚洲a∨国产av综合av下载| 久久人妻无码中文字幕第一| 自偷自拍亚洲综合精品麻豆| 亚洲国产精品无码中文字2022|