在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human papillomavirus type 16 protein E4 (E4)

Recombinant Human papillomavirus type 16 protein E4 (E4)

  • 中文名稱：
    Recombinant Human papillomavirus type 16 protein E4(E4)
  • 貨號：
    CSB-YP356968HML
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human papillomavirus type 16 protein E4(E4)
  • 貨號：
    CSB-EP356968HML-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human papillomavirus type 16 protein E4(E4)
  • 貨號：
    CSB-BP356968HML
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human papillomavirus type 16 protein E4(E4)
  • 貨號：
    CSB-MP356968HML
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    E4
  • Uniprot No.：
  • 別名：
    E4; Protein E4; E1^E4
  • 種屬：
    Human papillomavirus type 16
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-95
  • 氨基酸序列
    YYVLHLCLAA TKYPLLKLLG STWPTTPPRP IPKPSPWAPK KHRRLSSDQD QSQTPETPAT PLSCCTETQW TVLQSSLHLT AHTKDGLTVI VTLHP
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Contributes to multiple aspects of the viral life cycle including viral genome amplification, suppression of suprabasal cell differentiation and egress of newly formed virions. Induces host cell cycle arrest at the G2 phase by associating with and preventing the nuclear entry of host CDK1/cyclin B1 complexes. Inhibits cellular DNA replication by preventing loading of host replication licensing proteins MCM2 and MCM7 onto chromatin. Within the cytoplasm, associates with host kinase SRPK1, a splicing factor regulator, and inhibits its activity. Therefore, E4 favors expression of late viral transcripts by inhibiting SRPK1-mediated phosphorylation of host serine-arginine (SR) proteins that have critical roles in mRNA metabolism. Late in the infectious cycle, E4 also acts to diminish the integrity of the keratinocyte by disrupting the keratin cytoskeleton and inducing apoptosis through alteration of mitochondrial function to facilitate egress of the newly formed virions.
  • 基因功能參考文獻：
    1. These results suggest that 16E4-mediated enhancement of genome amplification involves its cell cycle inhibition and cellular kinase activation functions, with E4 modifying the activity and function of viral replication proteins including E1 PMID: 28306742
    2. Expression of the HPV16 E4 and E5 proteins results in a substantial change in the composition of the cell membrane and extracellular space, associated with alterations in cell adhesion and differentiation. PMID: 24898764
    3. 20 cervical cyology samples with HPV16 were tested by RT-PCR for HPV16 E4 mRNA, found in sqaumous intraepithelial lesion and squamous carcinoma, but not in samples negative for intrepithelial lesion. E4 expression assay may be useful in cancer diagnosis. PMID: 22299437
    4. The data suggest a model in which the expression of 16E5 from the major E1--E4-E5 mRNA promotes T57 phosphorylation of E1--E4 by ERK and keratin binding. PMID: 19211765
    5. identified the N-terminus of E2 as the first example of a viral protein that directly binds the E1--E4 protein PMID: 19783272

    顯示更多

    收起更多

  • 亞細胞定位：
    Host cytoplasm. Host nucleus.
  • 蛋白家族：
    Papillomaviridae E4 protein family
  • 數據庫鏈接：

    KEGG: vg:1489076



主站蜘蛛池模板： 老司机午夜免费精品视频| 亚洲制服丝中文字幕| 久久不见久久见免费视频1′| 三级网站视频在在线播放| 中文字幕人妻无码系列第三区| 久久99国产乱子伦精品免费| 无码人妻视频一区二区三区| 97精品国自产在线偷拍| 日韩做a爰片久久毛片a片| 亚洲欧美日韩在线一区| 国产午夜亚洲精品国产成人小说| 中文字幕乱码免费看电影| 女人被做到高潮免费视频| 人妻天天爽夜夜爽精品视频 | 亚洲成a人v电影在线观看| 精品人妻系列无码专区久久| 中文字幕亚洲无线码| 99久久国语露脸精品国产| 国产免费又色又爽又黄软件| 美女又色又爽视频免费| 丰满人妻被黑人猛烈进入| 无码日韩人妻精品久久| 精品国内自产拍在线播放观看| 一道精品视频一区二区三区| 麻豆国产成人av高清在线观看| 久久午夜羞羞影院免费观看| 国产真实夫妇交换视频| 午夜片无码区在线观看视频| 2021精品国产自在现线看| 97久久精品人人做人人爽| 久久久久久国产精品无码超碰| 亚洲人成人无码www| 正在播放国产剧情亂倫| 亚洲春色在线视频| 亚洲综合一区无码精品| 51被公侵犯玩弄漂亮人妻| 亚洲跨种族黑人xxxxx| 久久躁狠狠躁夜夜av| 亚洲精品国产成人精品| 狠狠亚洲色一日本高清色| 国产高清在线精品二区|