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  4. Recombinant Human immunodeficiency virus type 2 subtype A Protein Nef (nef)

Recombinant Human immunodeficiency virus type 2 subtype A Protein Nef (nef)

  • 中文名稱：
    Recombinant Human immunodeficiency virus type 2 subtype A Protein Nef(nef)
  • 貨號：
    CSB-YP321582HLU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human immunodeficiency virus type 2 subtype A Protein Nef(nef)
  • 貨號：
    CSB-EP321582HLU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human immunodeficiency virus type 2 subtype A Protein Nef(nef)
  • 貨號：
    CSB-EP321582HLU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human immunodeficiency virus type 2 subtype A Protein Nef(nef)
  • 貨號：
    CSB-BP321582HLU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human immunodeficiency virus type 2 subtype A Protein Nef(nef)
  • 貨號：
    CSB-MP321582HLU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    nef
  • Uniprot No.：
  • 別名：
    nef; Protein Nef; 3'ORF; Negative factor; F-protein
  • 種屬：
    Human immunodeficiency virus type 2 subtype A (isolate BEN) (HIV-2)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    2-257
  • 氨基酸序列
    GASGSKKLS KHSRGLRERL LRARGDGYGK QRDASGGEYS QFQEESGREQ NSPSCEGQQY QQGEYMNSPW RNPATERQKD LYRQQNMDDV DSDDDDLIGV PVTPRVPRRE MTYKLAIDMS HFIKEKGGLQ GMFYSRRRHR ILDIYLEKEE GIIPDWQNYT HGPGVRYPMY FGWLWKLVSV ELSQEAEEDE ANCLVHPAQT SRHDDEHGET LVWQFDSMLA YNYKAFTLYP EEFGHKSGLP EKEWKAKLKA RGIPYSE
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Factor of infectivity and pathogenicity, required for optimal virus replication. Alters numerous pathways of T-lymphocytes function and down-regulates immunity surface molecules in order to evade host defense and increase viral infectivity. Alters the functionality of other immunity cells, like dendritic cells, monocytes/macrophages and NK cells. One of the earliest and most abundantly expressed viral proteins.; In infected CD4(+) T-lymphocytes, down-regulates cell surface expression of CD4, CD28, CD3, and MHC-I or MHC-II molecules.; Interferes with TCR signaling from the cell membrane. Interacts with CD247/TCRZ (TCR zeta chain) and exert potent down-regulation of cell surface TCR/CD3 complexes.; Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike.; Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
  • 基因功能參考文獻：
    1. Nef-mediated downmodulation of TCR-CD3 and CD28 help viremic HIV-2-infected individuals to maintain normal CD4(+) T cell homeostasis PMID: 22345473
  • 亞細胞定位：
    Host cell membrane; Lipid-anchor; Cytoplasmic side.
  • 蛋白家族：
    Lentivirus primate group Nef protein family
  • 數據庫鏈接：

    KEGG: vg:1724715



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