在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Tat

  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Tat
  • 貨號:
    CSB-YP889537HGAJ
  • 說明書:
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Tat
  • 貨號:
    CSB-EP889537HGAJ
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Tat
  • 貨號:
    CSB-EP889537HGAJ-B
  • 說明書:
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Tat
  • 貨號:
    CSB-BP889537HGAJ
  • 說明書:
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype F1 Protein Tat
  • 貨號:
    CSB-MP889537HGAJ
  • 說明書:
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    tat
  • Uniprot No.:
  • 別名:
    tat; Protein Tat; Transactivating regulatory protein
  • 種屬:
    Human immunodeficiency virus type 1 group M subtype F1 (isolate VI850) (HIV-1)
  • 蛋白長度:
    full length protein
  • 表達區域:
    1-101
  • 氨基酸序列
    MEPVDPSLDP WNHPGSQPTT PCTKCYCKRC CFHCQWCFTT KGLGISYGRK KRRQRHRTPQ SSQVHQNSLP KQPLSQARGD PTGPKESKKE VESKAKTDPC A
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Nuclear transcriptional activator of viral gene expression, that is essential for viral transcription from the LTR promoter and replication. Acts as a sequence-specific molecular adapter, directing components of the cellular transcription machinery to the viral RNA to promote processive transcription elongation by the RNA polymerase II (RNA pol II) complex, thereby increasing the level of full-length transcripts. In the absence of Tat, the RNA Pol II generates short or non-processive transcripts that terminate at approximately 60 bp from the initiation site. Tat associates with the CCNT1/cyclin-T1 component of the P-TEFb complex (CDK9 and CCNT1), which promotes RNA chain elongation. This binding increases Tat's affinity for a hairpin structure at the 5'-end of all nascent viral mRNAs referred to as the transactivation responsive RNA element (TAR RNA) and allows Tat/P-TEFb complex to bind cooperatively to TAR RNA. The CDK9 component of P-TEFb and other Tat-activated kinases hyperphosphorylate the C-terminus of RNA Pol II that becomes stabilized and much more processive. Other factors such as HTATSF1/Tat-SF1, SUPT5H/SPT5, and HTATIP2 are also important for Tat's function. Besides its effect on RNA Pol II processivity, Tat induces chromatin remodeling of proviral genes by recruiting the histone acetyltransferases (HATs) CREBBP, EP300 and PCAF to the chromatin. This also contributes to the increase in proviral transcription rate, especially when the provirus integrates in transcriptionally silent region of the host genome. To ensure maximal activation of the LTR, Tat mediates nuclear translocation of NF-kappa-B by interacting with host RELA. Through its interaction with host TBP, Tat may also modulate transcription initiation. Tat can reactivate a latently infected cell by penetrating in it and transactivating its LTR promoter. In the cytoplasm, Tat is thought to act as a translational activator of HIV-1 mRNAs.; Extracellular circulating Tat can be endocytosed by surrounding uninfected cells via the binding to several surface receptors such as CD26, CXCR4, heparan sulfate proteoglycans (HSPG) or LDLR. Neurons are rarely infected, but they internalize Tat via their LDLR. Through its interaction with nuclear HATs, Tat is potentially able to control the acetylation-dependent cellular gene expression. Modulates the expression of many cellular genes involved in cell survival, proliferation or in coding for cytokines or cytokine receptors. Tat plays a role in T-cell and neurons apoptosis. Tat induced neurotoxicity and apoptosis probably contribute to neuroAIDS. Circulating Tat also acts as a chemokine-like and/or growth factor-like molecule that binds to specific receptors on the surface of the cells, affecting many cellular pathways. In the vascular system, Tat binds to ITGAV/ITGB3 and ITGA5/ITGB1 integrins dimers at the surface of endothelial cells and competes with bFGF for heparin-binding sites, leading to an excess of soluble bFGF.
  • 亞細胞定位:
    Host nucleus, host nucleolus. Host cytoplasm. Secreted.
  • 蛋白家族:
    Lentiviruses Tat family


主站蜘蛛池模板: 天天av天天翘天天综合网色鬼| 人妻无码手机在线中文| 老子影院无码午夜伦不卡| 免费精品99久久国产综合精品| 国产日韩精品一区二区三区在线| 日日做夜狠狠爱欧美黑人| 精品欧美小视频在线观看| 欧美日韩中文国产一区发布| 国产乱子伦精品视频| 国产美女自卫慰水免费视频| 久久精品人人做人人爽97| 久久人妻av中文字幕| 风流老熟女一区二区三区| 一边啪啪的一边呻吟声口述| 无码帝国www无码专区色综合| 美丽的熟妇中文字幕| 亚洲中文字幕无码日韩| 亚洲成在线aⅴ免费视频| 日本xxxx裸体xxxx视频大全| 丁香花在线影院观看在线播放 | 亚洲欧美综合区丁香五月小说 | 免费观看又污又黄的网站| 美女裸体自慰在线观看| 午夜国人精品av免费看| 亚洲人成网站18禁止中文字幕| 无码人妻aⅴ一区二区三区| 囯产精品久久久久久久久久妞妞| 日本久久久久久久久久加勒比| 国产一区二区三区高清在线观看| 偷拍区清纯另类丝袜美腿| 美女mm131爽爽爽作爱| 大香网伊人久久综合网2018| 女人被黑人狂躁c到高潮小说 | 久久精品国产精品亚洲蜜月| 国产人妻精品久久久久野外| 国产色诱视频在线观看| 久久理论片午夜琪琪电影院| 欧美极品少妇×xxxbbb| 午夜福利在线永久视频| 亚洲欧洲久久av| www夜插内射视频网站|