在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human immunodeficiency virus type 1 group M subtype D Protein Nef (nef)

  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype D Protein Nef(nef)
  • 貨號:
    CSB-YP361314HLL
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype D Protein Nef(nef)
  • 貨號:
    CSB-EP361314HLL
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype D Protein Nef(nef)
  • 貨號:
    CSB-EP361314HLL-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype D Protein Nef(nef)
  • 貨號:
    CSB-BP361314HLL
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype D Protein Nef(nef)
  • 貨號:
    CSB-MP361314HLL
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    nef
  • Uniprot No.:
  • 別名:
    nef; Protein Nef; 3'ORF; Negative factor; F-protein) [Cleaved into: C-terminal core protein]
  • 種屬:
    Human immunodeficiency virus type 1 group M subtype D (isolate Z6) (HIV-1)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-212
  • 氨基酸序列
    GGRWSKSSI VGWPAIRERI RRTDPRRTDP AADGVGAASR DLEKHGAITS SNTRDTNADC AWLEAQEESE EVGFPVRPQV PLRPMTYKLA VDLSHFLKEK GGLEGLIWSK KRQEILDLWV YNTQGIFPDW QNYTPGPGIR YPLTFGWCFE LVPVDPREVE EATEGETNCL LHPVCQHGME DTEREVLKWR FNSRLAFEHK AREMHPEFYK DC
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Factor of infectivity and pathogenicity, required for optimal virus replication. Alters numerous pathways of T-lymphocytes function and down-regulates immunity surface molecules in order to evade host defense and increase viral infectivity. Alters the functionality of other immunity cells, like dendritic cells, monocytes/macrophages and NK cells.; In infected CD4(+) T-lymphocytes, down-regulates the surface MHC-I, mature MHC-II, CD4, CD28, CCR5 and CXCR4 molecules. Mediates internalization and degradation of host CD4 through the interaction of with the cytoplasmic tail of CD4, the recruitment of AP-2 (clathrin adapter protein complex 2), internalization through clathrin coated pits, and subsequent transport to endosomes and lysosomes for degradation. Diverts host MHC-I molecules to the trans-Golgi network-associated endosomal compartments by an endocytic pathway to finally target them for degradation. MHC-I down-regulation may involve AP-1 (clathrin adapter protein complex 1) or possibly Src family kinase-ZAP70/Syk-PI3K cascade recruited by PACS2. In consequence infected cells are masked for immune recognition by cytotoxic T-lymphocytes. Decreasing the number of immune receptors also prevents reinfection by more HIV particles (superinfection). Down-regulates host SERINC3 and SERINC5 thereby excluding these proteins from the viral particles. Virion infectivity is drastically higher when SERINC3 or SERINC5 are excluded from the viral envelope, because these host antiviral proteins impare the membrane fusion event necessary for subsequent virion penetration.; Bypasses host T-cell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation. Interaction with TCR-zeta chain up-regulates the Fas ligand (FasL). Increasing surface FasL molecules and decreasing surface MHC-I molecules on infected CD4(+) cells send attacking cytotoxic CD8+ T-lymphocytes into apoptosis.; Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike. Inhibits the Fas and TNFR-mediated death signals by blocking MAP3K5/ASK1. Decreases the half-life of TP53, protecting the infected cell against p53-mediated apoptosis. Inhibits the apoptotic signals regulated by the Bcl-2 family proteins through the formation of a Nef/PI3-kinase/PAK2 complex that leads to activation of PAK2 and induces phosphorylation of host BAD.; Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
  • 亞細胞定位:
    Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane.
  • 蛋白家族:
    Lentivirus primate group Nef protein family


主站蜘蛛池模板: 国色天香社区视频手机免费| 国产无套内射普通话对白| 国产欧美高清在线观看| 琪琪女色窝窝777777| 亚洲一卡2卡3卡4卡国产| 最大胆裸体人体牲交免费| 中国美女毛茸茸撒尿| 亚洲精品无码久久久久| 男男女女爽爽爽免费视频| 2018高清国产一区二区三区| 午夜不卡av免费| 亚洲日韩乱码久久久久久| 女邻居的大乳中文字幕| 国产精品色拉拉| 成人奭片免费观看| 久久综合狠狠综合久久综合88| 各处沟厕大尺度偷拍女厕嘘嘘| 欧美兽交xxxx×视频| av天堂久久精品影音先锋| 国语自产偷拍精品视频蜜芽| 国产桃色无码视频在线观看| 精品一区二区不卡无码av| 日韩精品中文字幕无码专区 | 欧美亚洲人成网站在线观看| 十八禁无码免费网站| 亚洲另类无码一区二区三区| 99久久国产宗和精品1上映| 超级av在线天堂东京热| 亚洲综合激情七月婷婷| 少妇系列之白嫩人妻| 亚洲不乱码卡一卡二卡4卡5| 久久er99国产精品免费 | 真人与拘做受免费视频| 中文字幕精品久久久乱码乱码| 亚洲 欧美 天堂 综合| 夜色福利院在线观看免费| 免费无码av片在线观看潮喷| 裸体女人高潮毛片| 女人被狂躁的高潮免费视频| 伊人色综合久久天天| 中文字幕久精品免费视频|