在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human immunodeficiency virus type 1 group M subtype A Protein Nef (nef)

  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype A Protein Nef(nef)
  • 貨號:
    CSB-YP361315HKF
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype A Protein Nef(nef)
  • 貨號:
    CSB-EP361315HKF
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype A Protein Nef(nef)
  • 貨號:
    CSB-EP361315HKF-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype A Protein Nef(nef)
  • 貨號:
    CSB-BP361315HKF
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    Recombinant Human immunodeficiency virus type 1 group M subtype A Protein Nef(nef)
  • 貨號:
    CSB-MP361315HKF
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    nef
  • Uniprot No.:
  • 別名:
    nef; Protein Nef; 3'ORF; Negative factor; F-protein) [Cleaved into: C-terminal core protein]
  • 種屬:
    Human immunodeficiency virus type 1 group M subtype A (isolate MAL) (HIV-1)
  • 蛋白長度:
    Full Length of Mature Protein
  • 表達區域:
    2-209
  • 氨基酸序列
    GGKWSKSSI VGWPKIRERI RRTPPTETGV GAVSQDAVSQ DLDKCGAAAS SSPAANNASC EPPEEEEEVG FPVRPQVPLR PMTYKGAFDL SHFLKEKGGL DGLVWSPKRQ EILDLWVYHT QGYFPDWQNY TPGPGIRFPL TFGWCFKLVP MSPEEVEEAN EGENNCLLHP ISQHGMEDAE REVLKWKFDS SLALRHRARE QHPEYYKDC
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Factor of infectivity and pathogenicity, required for optimal virus replication. Alters numerous pathways of T-lymphocytes function and down-regulates immunity surface molecules in order to evade host defense and increase viral infectivity. Alters the functionality of other immunity cells, like dendritic cells, monocytes/macrophages and NK cells.; In infected CD4(+) T-lymphocytes, down-regulates the surface MHC-I, mature MHC-II, CD4, CD28, CCR5 and CXCR4 molecules. Mediates internalization and degradation of host CD4 through the interaction of with the cytoplasmic tail of CD4, the recruitment of AP-2 (clathrin adapter protein complex 2), internalization through clathrin coated pits, and subsequent transport to endosomes and lysosomes for degradation. Diverts host MHC-I molecules to the trans-Golgi network-associated endosomal compartments by an endocytic pathway to finally target them for degradation. MHC-I down-regulation may involve AP-1 (clathrin adapter protein complex 1) or possibly Src family kinase-ZAP70/Syk-PI3K cascade recruited by PACS2. In consequence infected cells are masked for immune recognition by cytotoxic T-lymphocytes. Decreasing the number of immune receptors also prevents reinfection by more HIV particles (superinfection). Down-regulates host SERINC3 and SERINC5 thereby excluding these proteins from the viral particles. Virion infectivity is drastically higher when SERINC3 or SERINC5 are excluded from the viral envelope, because these host antiviral proteins impare the membrane fusion event necessary for subsequent virion penetration.; Bypasses host T-cell signaling by inducing a transcriptional program nearly identical to that of anti-CD3 cell activation. Interaction with TCR-zeta chain up-regulates the Fas ligand (FasL). Increasing surface FasL molecules and decreasing surface MHC-I molecules on infected CD4(+) cells send attacking cytotoxic CD8+ T-lymphocytes into apoptosis.; Plays a role in optimizing the host cell environment for viral replication without causing cell death by apoptosis. Protects the infected cells from apoptosis in order to keep them alive until the next virus generation is ready to strike. Inhibits the Fas and TNFR-mediated death signals by blocking MAP3K5/ASK1. Decreases the half-life of TP53, protecting the infected cell against p53-mediated apoptosis. Inhibits the apoptotic signals regulated by the Bcl-2 family proteins through the formation of a Nef/PI3-kinase/PAK2 complex that leads to activation of PAK2 and induces phosphorylation of host BAD.; Extracellular Nef protein targets CD4(+) T-lymphocytes for apoptosis by interacting with CXCR4 surface receptors.
  • 亞細胞定位:
    Host cell membrane; Lipid-anchor; Cytoplasmic side. Virion. Secreted. Host Golgi apparatus membrane.
  • 蛋白家族:
    Lentivirus primate group Nef protein family


主站蜘蛛池模板: 国产精品久久综合免费| 色噜噜av亚洲色一区二区| 日日躁夜夜躁狠狠躁超碰97| 中文字字幕在线中文乱码| 精品日本一区二区免费视频| 天天爽夜夜爽视频精品| 少妇被爽到高潮喷水久久欧美精品| 国内精品国产三级国产av| 性色a∨人人爽网站hdkp885| 免费播放婬乱男女婬视频国产 | 国产精品高潮呻吟av久久小说| 国产两女互慰高潮视频在线观看 | 欧美另类 自拍 亚洲 图区| 免费看又黄又无码的网站 | 国产农村妇女毛片精品久久| 色窝窝无码一区二区三区| 99精品热这里只有精品| 青青草无码精品伊人久久| 精品久久无码中文字幕 | 国产女人爽的流水毛片| 久久成人国产精品无码| 在线中文字幕亚洲日韩2020| 中文字幕乱码在线播放| 日韩理论午夜无码| 亚洲精品无码精品mv在线观看| 精品无码一区二区三区av| 丰满熟妇人妻中文字幕 | 亚洲日韩va无码中文字幕| 欧美一道本一区二区三区| а√最新版在线天堂| 少妇太爽了在线观看| 国产成人无码精品久久久性色 | 亚洲 日韩 国产欧美 另类| 美女视频黄频a免费| 一二三区乱码不卡手机版| 激情综合五月丁香亚洲| 夜精品a片一区二区三区无码白浆| 山东熟女啪啪哦哦叫| 美女人妻激情乱人伦| 亚洲中文字幕无码日韩精品| 亚洲成av人片在线观看|