在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human herpesvirus 1 ICP47 protein (US12)

  • 中文名稱:
    Recombinant Human herpesvirus 1 ICP47 protein(US12)
  • 貨號:
    CSB-YP360979HWY
  • 規格:
    ¥2616
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    US12
  • Uniprot No.:
  • 別名:
    US12; ICP47 protein; Immediate-early protein IE12; Immediate-early-5; Infected cell protein 47; US12 protein; Vmw12
  • 種屬:
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白長度:
    Full Length
  • 來源:
    Yeast
  • 分子量:
    11.8kDa
  • 表達區域:
    1-88aa
  • 氨基酸序列
    MSWALEMADTFLDTMRVGPRTYADVRDEINKRGREDREAARTAVHDPERPLLRSPGLLPEIAPNASLGVAHRRTGGTVTDSPRNPVTR
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • 產品描述:

    The fusion tag N-terminal 6xHis tag gene was added to the gene sequence corresponding to the yeast of the HHV-1 US12 protein to form the recombinant DNA. The recombinant DNA was cloned into the expression vector and then transfected into the yeast cells for expression. Following purification, the product is the recombinant HHV-1 US12 protein carrying N-terminal 6xHis tag. The SDS-PAGE assessed the purity of this recombinant US12 protein up to 90%. It had an apparent molecular weight of approximately 14 kDa.

    US12 is gene providing instructions for making a protein named human herpesvirus 1 ICP47 protein (abbreviated US12) and belongs to Herpesviridae US12 family. US12, a HSV immediate early protein, is small protein produced by the herpes simplex virus, is considered as an important factor in the evasion of cellular immune responses in HSV-infected cells. It is expressed very early after infection and can inhibit CD8+ T cell recognition of infected cells. Recent studies have established clearly that ICP47 can bind with high affinity to human TAP and inhibit the transport of peptides into the endoplasmic reticulum.

  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role in the inhibition of host immune response. Binds specifically to transporters associated with antigen processing (TAP), thereby blocking peptide-binding and translocation by TAP as well as subsequent loading of peptides onto MHC class I molecules. Empty MHC I molecules are retained in the endoplasmic reticulum and ultimately directed to proteasomal degradation. In consequence, infected cells are masked for immune recognition by cytotoxic T-lymphocytes.
  • 基因功能參考文獻:
    1. The structure shows that herpes simplex virus ICP47 traps human TAP in an inactive conformation distinct from the normal transport cycle. PMID: 27935481
    2. cryo-electron microscopy structure of human TAP in complex with its inhibitor ICP47, a small protein produced by the herpes simplex virus I PMID: 26789246
    3. Results indicate that recombinant adenovirus r-H-ICP47 had the abilities of reducing the proliferation of lymphocytes activated by dendritic cells (DCs). PMID: 23774531
  • 亞細胞定位:
    Host cytoplasm. Host nucleus.
  • 蛋白家族:
    Herpesviridae US12 family
  • 數據庫鏈接:

    KEGG: vg:2703441



主站蜘蛛池模板: 国产农村妇女毛片精品久久| 精品国产杨幂在线观看| 新版资源天堂中文| 一本久道久久综合久久爱| 国产丰满人妻一区二区| 亚洲色大成网站www久久九九| 午夜家庭影院| 国产午夜亚洲精品区| 亚洲精品国产自在久久| 中文午夜人妻无码看片| 国产精品污www一区二区三区| 中文字幕人成乱码熟女app| 日本一道综合久久aⅴ免费| 久热这里在线精品| 亚洲hdmi高清线| 搡老女人老妇女老熟妇| 一本久道高清无码视频| 欧美精品九九久久久久久久久| 99久久国产综合精品五月天| 文中字幕一区二区三区视频播放 | 中文字幕av一区二区三区人妻少妇| 亚洲人成网站观看在线播放| 18禁黄网站禁片免费观看不卡| 无码啪啪熟妇人妻区| 在线看亚洲十八禁网站| 无遮挡又爽又刺激的视频| 无码免费无线观看在线视| 日韩一区二区三区四区区区| 无套内谢孕妇毛片免费看| 亚洲男人的天堂网站| 久久九九有精品国产23百花影院 | 动漫人妻h无码中文字幕| 成人污污污www网站免费| 精品人伦一区二区三电影| 亚洲精品蜜夜内射| 色噜噜狠狼综合在线| 国内精品2020情侣视频| 国产黄a三级三级三级| 久久久综合香蕉尹人综合网| 久久亚洲国产最新网站之一| 特黄做受又粗又大又硬老头|