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  4. Recombinant Human herpesvirus 1 Envelope glycoprotein D (gD), partial

Recombinant Human herpesvirus 1 Envelope glycoprotein D (gD), partial

  • 中文名稱：
    Recombinant Human herpesvirus 1 Envelope glycoprotein D(gD) ,partial
  • 貨號：
    CSB-YP721295HWY1
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Envelope glycoprotein D(gD) ,partial
  • 貨號：
    CSB-EP721295HWY1
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Envelope glycoprotein D(gD) ,partial
  • 貨號：
    CSB-EP721295HWY1-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Envelope glycoprotein D(gD) ,partial
  • 貨號：
    CSB-BP721295HWY1
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human herpesvirus 1 Envelope glycoprotein D(gD) ,partial
  • 貨號：
    CSB-MP721295HWY1
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    gD
  • Uniprot No.：
  • 別名：
    gD; US6; Envelope glycoprotein D; gD
  • 種屬：
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Envelope glycoprotein that binds to the potential host cell entry receptors TNFRSF14/HVEM, NECTIN1 and 3-O-sulfated heparan sulfate. May trigger fusion with host membrane, by recruiting the fusion machinery composed of gB and gH/gL.
  • 基因功能參考文獻：
    1. HSV gD is able to disrupt intercellular homophilic trans-interaction of nectin-1 and induce a rapid redistribution of nectin-1 from cell junctions. PMID: 27723487
    2. Syncytial mutations do not impair the specificity of entry and spread of a Glycoprotein D receptor-retargeted Herpes Simplex Virus. PMID: 27707922
    3. gD V231W induced cell-cell fusion in the absence of receptor. PMID: 24049165
    4. actively induces rapid internalization of various forms of nectin-1, suggesting that HSV activates a nectin-1 internalization pathway to use for endocytic entry PMID: 20089288
    5. Structural features of gD, including conformation of the N terminus, critical for functional interactions with HVEM/3-O-sulfated heparan sulfate, differ from those critical for interactions with nectin-1. PMID: 15557552
    6. length of the tandem repeat region was determined for 82 clinical HSV-1 isolates and the results revealed a polymorphic distribution of two to six or eight repeated blocks with a majority harbouring between two and four repeats PMID: 17485527
    7. Based upon the properties of the panel of mutants we conclude that fusion requires greater flexibility of the gD ectodomain C terminus than does receptor binding. PMID: 18032483
    8. These data suggest that the determinants of gD-mediated internalization of nectin-1 may direct HSV to an endocytic pathway during entry. PMID: 18076965
    9. These results establish that HVEM is involved in NF-kappaB activation by herpes simplex virus 1 glycoprotein D. PMID: 18671825

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  • 亞細胞定位：
    Virion membrane; Single-pass type I membrane protein. Host Golgi apparatus.
  • 蛋白家族：
    Herpesviridae glycoprotein D family
  • 數據庫鏈接：

    KEGG: vg:2703444



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