在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human herpesvirus 1 Accessory factor US11 (US11)

In Stock
  • 中文名稱:
    Recombinant Human herpesvirus 1 Accessory factor US11(US11)
  • 貨號:
    CSB-EP366164HWY
  • 規格:
    ¥2328
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 85% as determined by SDS-PAGE.
  • 基因名:
    US11
  • Uniprot No.:
  • 別名:
    US11; Accessory factor US11; Vmw21
  • 種屬:
    Human herpesvirus 1 (strain 17) (HHV-1) (Human herpes simplex virus 1)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    25.2 kDa
  • 表達區域:
    1-161aa
  • 氨基酸序列
    MSQTQPPAPVGPGDPDVYLKGVPSAGMHPRGVHAPRGHPRMISGPPQRGDNDQAAGQCGDSGLLRVGADTTISKPSEAVRPPTIPRTPRVPREPRVPRPPREPREPRVPRAPRDPRVPRDPRDPRQPRSPREPRSPREPRSPREPRTPRTPREPRTARGSV
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 10xHis-tagged and C-terminal Myc-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    Tris-based buffer,50% glycerol
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Plays a role in the inhibition of host immune response. Participates in the inhibition of host autophagy by interacting with and inhibiting host PKR/EIF2AK2. This interaction also prevents the interferon-induced shut down of protein synthesis following viral infection. Downmodulates the host RLR signaling pathway via direct interaction with host DDX58 and IFIH1. Associates with endogenous HSP90 to disrupt the HSP90-TBK1 complex and induces destabilization of host TBK1 through a proteasome-dependent pathway. May also participate in nuclear egress of viral particles through interactions with host NCL and regulation of the viral UL34 mRNA.
  • 基因功能參考文獻:
    1. Nucleophosmin Interactions with Human Immunodeficiency Virus Rev and Herpes Simplex Virus US11 PMID: 26624888
    2. Herpes simplex virus 1 Us11 suppresses host interferon beta1 production through the inhibition of the PACT. PMID: 24067967
    3. Herpes simplex virus type 1 virion-derived US11 inhibits type 1 interferon-induced protein kinase R phosphorylation. PMID: 23773021
    4. PKR expression and the PKR binding domain of herpes simplex virus 1 Us11 are required for the antiautophagic activity of Us11. PMID: 23115300
    5. HSV-1 US11 binds to RIG-I and MDA-5 and inhibits their downstream signaling pathway. PMID: 22301138
    6. found an increase in the nucleolar accumulation of US11 in nucleolin-depleted cells, thereby revealing that nucleolin could play a role in US11 nucleocytoplasmic trafficking through one-way directional transport out of the nucleolus PMID: 22130536
    7. By constructing a series of deletion mutants fused with enhanced yellow fluorescent protein, three novel nucleolar localization signals of US11 were for the first time mapped to amino acids 84-125, 126-152, and 89-146, respectively. PMID: 20633584
    8. The binding site of the RNA-binding domain of US11 to RNA was characterized. PMID: 16246910
    9. herpes simplex virus type 1 Us11 gene product is able to counteract the activity of 2'-5' oligoadenylate synthetase, a third cellular protein critical for host defense PMID: 17229694
    10. The results favor an anti-apoptotic activity of US11 polypeptide that appears to be located at the level of mitochondria or upstream signaling pathways. PMID: 18395766

    顯示更多

    收起更多

  • 亞細胞定位:
    Host nucleus, host nucleolus. Host cytoplasm. Note=Following infection, it is released into the cell cytoplasm.
  • 蛋白家族:
    Simplex virus US11 protein family
  • 數據庫鏈接:

    KEGG: vg:2703439



主站蜘蛛池模板: 亚洲色无码中文字幕在线| 国产精品无码一区二区桃花视频| 亚洲精品一区国产| 性色高清xxxxx厕所偷窥| 狠狠色噜噜狠狠狠888777米奇 | 亚洲国产精品国自产拍电影| 老司机在线精品视频网站| 久久只精品99品免费久23| 少妇被爽到高潮喷水久久欧美精品| аⅴ天堂中文在线网| 男人添女人下部高潮视频| 亚洲的天堂av无码| 国产一区视频一区欧美| 怡红院av亚洲一区二区三区h| 国产区又黄又硬高潮的视频| 丁香花在线影院观看在线播放 | 国产精品日本一区二区在线播放| 色妞色综合久久夜夜| 国产精品综合av一区二区国产馆| 中文字幕丰满孑伦无码精品| 国产区精品福利在线社区| 99热国产这里只有精品6| 国产aⅴ精品一区二区三区久久| 亚洲中文字幕无码av| 少妇特黄a一区二区三区| 内射老阿姨1区2区3区4区| 免费观看国产小粉嫩喷水| 又大又黄又粗又爽的免费视频| 极品少妇的粉嫩小泬视频| 午夜无码人妻av大片色欲| 国产成人无码a区在线观看视频免费| 在教室伦流澡到高潮hgl动漫| 欧洲熟妇色 欧美| 女人被强╳到高潮喷水在线观看| 亚洲6080yy久久无码产自国产 | 688欧美人禽杂交狂配| 人妻洗澡被强公日日澡电影| 精品欧洲av无码一区二区| 欧美成人高清视频a在线看| 国产亚洲精品久久yy5099| 亚洲欧洲美色一区二区三区|