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  4. Recombinant Human Zinc finger protein castor homolog 1 (CASZ1), partial

Recombinant Human Zinc finger protein castor homolog 1 (CASZ1), partial

  • 中文名稱：
    Recombinant Human Zinc finger protein castor homolog 1(CASZ1) ,partial
  • 貨號：
    CSB-YP773036HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Zinc finger protein castor homolog 1(CASZ1) ,partial
  • 貨號：
    CSB-EP773036HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Zinc finger protein castor homolog 1(CASZ1) ,partial
  • 貨號：
    CSB-EP773036HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Zinc finger protein castor homolog 1(CASZ1) ,partial
  • 貨號：
    CSB-BP773036HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Zinc finger protein castor homolog 1(CASZ1) ,partial
  • 貨號：
    CSB-MP773036HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    2410019P08Rik; AV096627; BC040081; BOS_15820; Castor-related protein; CASZ1; CASZ1_HUMAN; CST; D4Ertd432e; dJ734G22.1; FLJ12223; FLJ20321; MGC155102; MGC31683; OTTMUSP00000011746; OTTMUSP00000011748; Putative survival-related protein; RP23-230I5.1; RP4-734G22.2; SRG; Survival related; Zinc finger protein 693; Zinc finger protein castor homolog 1; ZNF693
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcriptional activator. Involved in vascular assembly and morphogenesis through direct transcriptional regulation of EGFL7.
  • 基因功能參考文獻：
    1. Collectively, our proteomic, biochemical, genetic, and structural studies suggest that the physical interaction between TBX20 and CASZ1 is required for cardiac homeostasis, and further, that reduction or loss of this critical interaction leads to dilated cardiomyopathy (DCM) PMID: 28945738
    2. These findings provide insight into mechanisms by which CASZ1 regulates transcription, and suggests that regulation of CASZ1 subcellular localization may impact its function in normal development and pathologic conditions such as NB tumorigenesis. PMID: 27270431
    3. The current study reveals CASZ1 as a new gene responsible for human dilated cardiomyopathy (DCM), which provides novel mechanistic insight and potential therapeutic target for CASZ1-associated DCM, implying potential implications in improved prophylactic and therapeutic strategies for DCM, the most common type of primary myocardial disease. PMID: 28099117
    4. the current study firstly identifies CASZ1 as a new gene predisposing to congenital heart disease in humans PMID: 27693370
    5. CASZ1b binds to chromatin and recruits NuRD complexes to orchestrate epigenetic-mediated transcriptional programs PMID: 26296975
    6. CASZ1 inhibits cell cycle progression in neuroblastoma by restoring retinoblastoma protein activity. PMID: 23892435
    7. Papillomavirus DNA integration is associated with loss of CASZ1 gene and thus cervical carcinogenesis. PMID: 22262398
    8. This study identifies key domains needed for CASZ1b to regulate gene transcription; a link between loss of CASZ1b transcriptional activity and attenuation of CASZ1b-mediated inhibition of neuroblastoma growth and tumorigenicity PMID: 22331471
    9. determined that the tumor suppressors CLU, NGFR, and RUNX3 were also directly repressed by EZH2 like CASZ1 in NB cells PMID: 22068036
    10. CASZ1 is a critical modulator of neural cell development, and that somatically acquired disruption of normal CASZ1 expression contributes to the malignant phenotype of human Neuroblastoma. PMID: 21252912
    11. The study indicates that although their mechanisms of regulation may be distinct, both CASZ1b and CASZ1a have largely redundant but critical roles in suppressing tumor cell growth. PMID: 21490919
    12. CASZ1 is expressed in a number of human tumors and localizes to a chromosomal region frequently lost in tumors of neuroectodermal origin. PMID: 16631614

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Expressed in heart, lung, skeletal muscle, pancreas, testis, small intestine, and stomach, but it is not detectable in the adult brain.
  • 數據庫鏈接：

    HGNC: 26002

    OMIM: 609895

    KEGG: hsa:54897

    STRING: 9606.ENSP00000366221

    UniGene: Hs.439894



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