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  4. Recombinant Human Zinc finger protein basonuclin-2 (BNC2), partial

Recombinant Human Zinc finger protein basonuclin-2 (BNC2), partial

  • 中文名稱：
    Recombinant Human Zinc finger protein basonuclin-2(BNC2) ,partial
  • 貨號：
    CSB-YP751153HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    Recombinant Human Zinc finger protein basonuclin-2(BNC2) ,partial
  • 貨號：
    CSB-EP751153HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    Recombinant Human Zinc finger protein basonuclin-2(BNC2) ,partial
  • 貨號：
    CSB-EP751153HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    Recombinant Human Zinc finger protein basonuclin-2(BNC2) ,partial
  • 貨號：
    CSB-BP751153HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    Recombinant Human Zinc finger protein basonuclin-2(BNC2) ,partial
  • 貨號：
    CSB-MP751153HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    BNC2Zinc finger protein basonuclin-2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Probable transcription factor specific for skin keratinocytes. May play a role in the differentiation of spermatozoa and oocytes. May also play an important role in early urinary-tract development.
  • 基因功能參考文獻：
    1. the intergenic region located around rs3814113 regulates BNC2 expression, which in turn affects cell survival after oxidative stress response. PMID: 27899818
    2. This study suggests a functional role of BNC2 in the development and progression of the spinal deformity in adolescent idiopathic scoliosis. PMID: 28342042
    3. Study indicates that BNC2 expression was down-regulated in hepatocellular tumors and cell lines showing a frequent gene deletion. PMID: 26821013
    4. A functional SNP leading to increased expression in BNC2 is implicated in the etiology of Adolescent Idiopathic Scoliosis. PMID: 26211971
    5. BNC2 gene mutation influencing facial pigmented spots. PMID: 25705849
    6. Human skin color is influenced by an intergenic DNA polymorphism regulating transcription of the nearby BNC2 pigmentation gene. PMID: 24916375
    7. follow-up studies are necessary to establish the role of BNC2 in blood-based DNA and epithelial ovarian cancer (EOC), including prospective studies to validate this region as a potential biomarker and predictor of EOC susceptibility PMID: 24853948
    8. We identified two new skin color genes: genetic variants in UGT1A were significantly associated with hue and variants in BNC2 were significantly associated with saturation. PMID: 23052946
    9. Data indicate that the SNPs are located in the region of the BNC2 gene which is involved in ovarian development. PMID: 21750727
    10. results suggest that the analysed polymorphisms in the BNC2 gene are unlikely to contribute to the previously reported risk of ovarian cancer in women with endometriosis PMID: 21642636
    11. The association of BNC2 disruption with distal urethral defects and the gene's expression pattern indicate that it functions in urethral development. PMID: 21368915
    12. the 4 recently reported SNPs,located near BNC2, SORCS1, GSC and WDR72 loci, affecting glycemic control in type 1 diabetes had no apparent effect on HbA1c in type 2 diabetes; but, for SORCS1 SNP, findings do not rule out possible relationship with HbA1c PMID: 21294870
    13. Single nucleotide polymorphism in BNC2 is associated with ovarian cancer. PMID: 20852632
    14. the extreme conservation of the basonuclin 2 amino acid sequence across vertebrates suggests that basonuclin 2 serves an important function, presumably as a regulatory protein of DNA transcription PMID: 14988505
    15. molecular cloning PMID: 15081112
    16. Data show that basonuclin (Bn)2 but not bn1 colocalizes with SC35 in nuclear speckles, and may have a function in nuclear processing of mRNA. PMID: 16891417
    17. transcripts are initiated from six promoters, are alternatively spliced at multiple positions, and are polyadenylated at four sites PMID: 16942855
    18. Loss of BNC2 is associated with esophageal adenocarcinoma. PMID: 19670330

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  • 亞細胞定位：
    Nucleus.
  • 組織特異性：
    Highly expressed in testis, uterus and small intestine, and weakly expressed in colon and prostate. Also expressed in skin, primary keratinocytes, immortalized keratinocytes, and HeLa and HEK293 cells. Not detected in blood, thymus, spleen or Hep-G2 cells
  • 數據庫鏈接：

    HGNC: 30988

    OMIM: 608669

    KEGG: hsa:54796

    STRING: 9606.ENSP00000370047

    UniGene: Hs.656581



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