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  4. Recombinant Human Zinc finger protein ZFPM2 (ZFPM2), partial

Recombinant Human Zinc finger protein ZFPM2 (ZFPM2), partial

  • 中文名稱：
    人ZFPM2重組蛋白
  • 貨號：
    CSB-YP855487HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ZFPM2重組蛋白
  • 貨號：
    CSB-EP855487HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ZFPM2重組蛋白
  • 貨號：
    CSB-EP855487HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ZFPM2重組蛋白
  • 貨號：
    CSB-BP855487HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ZFPM2重組蛋白
  • 貨號：
    CSB-MP855487HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ZFPM2
  • Uniprot No.：
  • 別名：
    FOG-2; FOG2_HUMAN; Friend of GATA 2; Friend of GATA protein 2; Friend of GATA2; hFOG-2; ZFPM2; Zinc finger protein 89B; Zinc finger protein M2; Zinc finger protein multitype 2; Zinc finger protein ZFPM2
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Transcription regulator that plays a central role in heart morphogenesis and development of coronary vessels from epicardium, by regulating genes that are essential during cardiogenesis. Essential cofactor that acts via the formation of a heterodimer with transcription factors of the GATA family GATA4, GATA5 and GATA6. Such heterodimer can both activate or repress transcriptional activity, depending on the cell and promoter context. Also required in gonadal differentiation, possibly be regulating expression of SRY. Probably acts a corepressor of NR2F2.
  • 基因功能參考文獻：
    1. The single nucleotide polymorphisms (SNPs) of NKX2.5, GATA4, and TBX5 are highly associated with congenital heart diseases in the Chinese population, but not significant in the SNPs of FOG2. PMID: 29972125
    2. when ZFPM2R698Q was co-transfected with GATA4, BNP promoter activity increased significantly, whereas co-transfection with ZFPM2R736L and GATA4 did not significantly increase BNP promoter activity. This suggests that the R698Q mutation may affect the ability of ZFPM2 to bind GATA4. PMID: 29018978
    3. Aberrant methylation status at the promoter CpG island shore of ZFPM2 gene may be associated with its gene transcription regulation in the tetralogy of fallot patients PMID: 26959486
    4. Genetic Analysis of Venous Thromboembolism in UK Biobank Identifies the ZFPM2 Locus and Implicates Obesity as a Causal Risk Factor. PMID: 28373160
    5. ZFPM2 is a glioma susceptibility gene, its genotype and expression showing associations with incidence and severity. The balancing selection acting on ZFPM2 may relate to its roles in multiple organ development or associated disease etiology. PMID: 26207917
    6. Isolated congenital diaphragmatic hernia was the predominant phenotype observed in our ZFPM2 mutation patients. PMID: 24702427
    7. screened a larger CTD population, which comprised 145 tetralogy of Fallot (TOF), 37 double-outlet ventricle outflow (DORV), and 18 transposition of the great artery (TGA), to investigate exon mutations as well as copy number variations in ZFPM2/FOG2 PMID: 25025186
    8. Whole exome sequencing identified independent missense mutations in FOG2 in two patients with 46,XY gonadal dysgenesis. PMID: 24549039
    9. Findings indicate that zinc finger protein, multitype 2 protein (ZFPM2) plays a role in diaphragm and cardiovascular development. PMID: 24769157
    10. Art27 interacts with GATA4, FOG2 and NKX2.5 and is a novel co-repressor of cardiac genes. PMID: 24743694
    11. our results provide strong evidence regarding the susceptibility of the ZFPM2 gene to the development of non-syndromic TOF/DORV. PMID: 24469719
    12. FOG1, FOG2 and GATA-6 modulate the transcriptional up-regulation of HAMP in hepatocytes during inflammation. PMID: 24179092
    13. Variants of the ZFPM2/FOG2 gene might be a common cause of Double outlet right ventricle. PMID: 21919901
    14. Sex Cord Stromal Tumors in childhood exhibited an embryonal gonadal phenotype, expressing a FOG-2/GATA-4 pattern in keeping with embryonal gonads. PMID: 23029311
    15. association of the ZFPM2 SNP, rs12678719, with antipsychotic-induced parkinsonism PMID: 21947317
    16. New mutations in ZFPM2/FOG2 gene in tetralogy of Fallot and double outlet right ventricle PMID: 20807224
    17. These results implicate FOG1 and 2 and CTBPs as partners of GATA proteins in the control of adipocyte proliferation and differentiation. PMID: 20705609
    18. FOG-2 has specific role in fetal ovaries counteracting transactivation of mullerian-inhibiting substance gene by GATA-4. Important role for FOG-2 and GATA transcription factors in developing ovary. PMID: 12606418
    19. AML1-FOG2 and FOG2-AML1 are expressed in myelodysplastic syndrome; results suggest a central role for CtBP in AML1-FOG2 transcriptional repression and implicate coordinated disruption of AML1 and GATA developmental programs in the disease pathogenesis PMID: 15705784
    20. FOG-2 affects not only cardiac development but also gonadal function and its preservation PMID: 17309641
    21. sequence variation in diaphragmatic hernia PMID: 17568391
    22. SERCA2 is an important target of FOG-2 and that increased FOG-2 expression may contribute to a decline in cardiac function in end-stage heart failure by impaired T3 signaling PMID: 18658259
    23. Comparative analyses identify USH and its human homolog, FOG2, as the targets of fly miR-8 and human miR-200, respectively; USH/FOG2 inhibits PI3K activity, suppressing cell growth in both flies and humans. PMID: 20005803

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  • 相關疾病：
    Tetralogy of Fallot (TOF); Diaphragmatic hernia 3 (DIH3); 46,XY sex reversal 9 (SRXY9); Conotruncal heart malformations (CTHM)
  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    FOG (Friend of GATA) family
  • 組織特異性：
    Widely expressed at low level.
  • 數據庫鏈接：

    HGNC: 16700

    OMIM: 187500

    KEGG: hsa:23414

    STRING: 9606.ENSP00000384179

    UniGene: Hs.431009



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