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  4. Recombinant Human Zinc finger protein 512B (ZNF512B), partial

Recombinant Human Zinc finger protein 512B (ZNF512B), partial

  • 中文名稱：
    人ZNF512B重組蛋白
  • 貨號：
    CSB-YP026803HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ZNF512B重組蛋白
  • 貨號：
    CSB-EP026803HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ZNF512B重組蛋白
  • 貨號：
    CSB-EP026803HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ZNF512B重組蛋白
  • 貨號：
    CSB-BP026803HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ZNF512B重組蛋白
  • 貨號：
    CSB-MP026803HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ZNF512B
  • Uniprot No.：
  • 別名：
    ZNF512B; KIAA1196Zinc finger protein 512B
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    May be involved in transcriptional regulation.
  • 基因功能參考文獻：
    1. Five case-control studies involving 2559 patients with sporadic amyotrophic lateral sclerosis (ALS) and 5740 controls were analyzed. Based on random-effects meta-analysis, the ZNF512B polymorphism rs2275294 was associated with increased risk of ALS disease in an allele model. The available evidence suggests that the ZNF512B polymorphism rs2275294 is associated with ALS risk. PMID: 29713939
    2. Single nucleotide polymorphism (SNP) rs2275294 associated with susceptibility to sporadic ALS (sALS) in the ZNF512B gene on chromosome 20q13.33. PMID: 28740063
    3. Genetic Analysis of the ZNF512B, SLC41A1, and ALDH2 Polymorphisms in Parkinson's Disease in the Iranian Population. PMID: 27612022
    4. The SNP rs2275294 in ZNF512B is not considered to be associated with ALS susceptibility in the Chinese population. Our PMID: 26668144
    5. In conclusion, our case-control study suggests that the CC genotype and C allele at rs2275294 are associated with increased risk of ALS in Han Chinese, particularly females. PMID: 26313240
    6. The objective of our study was to examine whether the new single-nucleotide polymorphism in the ZNF512B gene might influence the phenotype of amyotrophic lateral sclerosis PMID: 23168171
    7. A functional SNP (rs2275294) in ZNF512B was found to be significantly associated with amyotrophic lateral sclerosis in Japanese. PMID: 21665992
    8. Evidence that GAM/ZFp/ZNF512B may potentially maintain homeostasis by affecting the levels of regulators such as E2F1 and Ras, by modulating miR-17-92 miRNAs, by interacting with Drosha, and by interfering with TGFbeta signaling. PMID: 20639536

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  • 亞細胞定位：
    Nucleus.
  • 蛋白家族：
    Krueppel C2H2-type zinc-finger protein family
  • 數據庫鏈接：

    HGNC: 29212

    OMIM: 617886

    KEGG: hsa:57473

    STRING: 9606.ENSP00000217130

    UniGene: Hs.740578



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