在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Zinc finger and BTB domain-containing protein 24 (ZBTB24)

  • 中文名稱:
    人ZBTB24重組蛋白
  • 貨號:
    CSB-YP026321HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人ZBTB24重組蛋白
  • 貨號:
    CSB-EP026321HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人ZBTB24重組蛋白
  • 貨號:
    CSB-EP026321HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人ZBTB24重組蛋白
  • 貨號:
    CSB-BP026321HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人ZBTB24重組蛋白
  • 貨號:
    CSB-MP026321HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    ZBTB24
  • Uniprot No.:
  • 別名:
    BIF1; ICF2; OTTHUMP00000016968; POZ (BTB) and AT hook containing zinc finger 2; ZBT24_HUMAN; Zbtb24; Zinc finger and BTB domain-containing protein 24; Zinc finger protein 450; ZNF45
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-697
  • 氨基酸序列
    MAETSPEPSG QLVVHSDAHS DTVLASFEDQ RKKGFLCDIT LIVENVHFRA HKALLAASSE YFSMMFAEEG EIGQSIYMLE GMVADTFGIL LEFIYTGYLH ASEKSTEQIL ATAQFLKVYD LVKAYTDFQN NHSSPKPTTL NTAGAPVVVI SNKKNDPPKR KRGRPKKVNT LQEEKSELAA EEEIQLRVNN SVQNRQNFVV KGDSGVLNEQ IAAKEKEESE PTCEPSREEE MPVEKDENYD PKTEDGQASQ SRYSKRRIWR SVKLKDYKLV GDQEDHGSAK RICGRRKRPG GPEARCKDCG KVFKYNHFLA IHQRSHTGER PFKCNECGKG FAQKHSLQVH TRMHTGERPY TCTVCSKALT TKHSLLEHMS LHSGQKSFTC DQCGKYFSQN RQLKSHYRVH TGHSLPECKD CHRKFMDVSQ LKKHLRTHTG EKPFTCEICG KSFTAKSSLQ THIRIHRGEK PYSCGICGKS FSDSSAKRRH CILHTGKKPF SCPECNLQFA RLDNLKAHLK IHSKEKHASD ASSISGSSNT EEVRNILQLQ PYQLSTSGEQ EIQLLVTDSV HNINFMPGPS QGISIVTAES SQNMTADQAA NLTLLTQQPE QLQNLILSAQ QEQTEHIQSL NMIESQMGPS QTEPVHVITL SKETLEHLHA HQEQTEELHL ATSTSDPAQH LQLTQEPGPP PPTHHVPQPT PLGQEQS
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    May be involved in BMP2-induced transcription.
  • 基因功能參考文獻:
    1. data indicate that SRRM4 regulates alternative RNA splicing of the Bif-1 gene that enables PCa cells resistant to apoptotic stimuli under anti-cancer therapies, and may contribute to AdPC progression into t-NEPC. PMID: 29759485
    2. The biallelic deletion of ZBTB24 provides strong support for the hypothesis that most ICF2 patients suffer from a ZBTB24 loss of function mechanism and confirms that complete absence of ZBTB24 is compatible with human life. This is in contrast to the observed early embryonic lethality in mice lacking functional Zbtb24 PMID: 28128455
    3. Transcriptome analysis identified Cdca7 as the top down-regulated gene in Zbtb24 homozygous mutant mESCs, which can be restored by ectopic ZBTB24 expression. Finally, we show that this regulation is conserved between species and that CDCA7 levels are reduced in patients carrying ZBTB24 nonsense mutations PMID: 27466202
    4. Downregulation of ZBTB24 increases the expression of IRF-4 and reduces b-cell proliferation. PMID: 27098601
    5. Our results demonstrate a novel role of Bif-1 in hepatocellular carcinoma (HCC), in which Bif-1 promotes cell metastasis by regulating Cdc42 expression and activity. PMID: 27730394
    6. ICF2, caused by biallelic ZBTB24 gene mutations, is acknowledged primarily as an isolated B-cell defect. PMID: 25330735
    7. This suggests that Bif-1 protein expression may be a useful prognostic marker in early-stage CRC PMID: 24175288
    8. Clinical and genetic data of mutations in DNMT3B and ZBTB24 in patients with ICF syndrome, were compared. PMID: 23486536
    9. We report three novel ZBTB24 mutations in Japanese and Cape Verdean type 2 ICF syndrome patients. PMID: 23739126
    10. A novel deletion in the ZBTB24 gene was responsible for causing immunodeficiency, centromeric instability and facial anomalies syndrome type 2 in this family. PMID: 21906047
    11. These data indicate that ZBTB24 is involved in DNA methylation of juxtacentromeric DNA and in B cell development and/or B and T cell interactions. PMID: 21596365

    顯示更多

    收起更多

  • 相關疾病:
    Immunodeficiency-centromeric instability-facial anomalies syndrome 2 (ICF2)
  • 亞細胞定位:
    Nucleus.
  • 蛋白家族:
    Krueppel C2H2-type zinc-finger protein family
  • 組織特異性:
    Widely expressed, with highest levels in naive B-cells.
  • 數據庫鏈接:

    HGNC: 21143

    OMIM: 614064

    KEGG: hsa:9841

    STRING: 9606.ENSP00000230122

    UniGene: Hs.409876



主站蜘蛛池模板: 真人抽搐一进一出视频| 影音先锋无码a∨男人资源站| 护士av无码在线观看| 内射人妻无码色ab麻豆| 国产精品精华液网站| 国产jjzzjjzz视频全部免费| 国产免费爽爽视频在线观看| 国产精品久久久久久熟妇吹潮软件 | 日产无码中文字幕av| 国产精品美女久久久m| 初尝黑人巨砲波多野结衣| 国产情侣久久久久aⅴ免费| 漂亮人妻熟睡中被公侵犯中文版| av综合网男人的天堂| 妺妺窝人体色www在线观看| 国内露脸中年夫妇交换| 玩弄放荡人妇系列av在线网站 | 国产女人喷潮视频免费| 久久精品中文字幕第一页| 中文字字幕人妻中文| 日韩欧美成人免费观看| 国色天香社区视频手机免费| 久热这里只有精品12| 亚洲成色www久久网站| 国产草莓精品国产av片国产| 日本xxxx丰满老妇| 久久成人国产精品| 国产午夜精品一区二区三区嫩草| 日韩av一国产av一中文字慕| 亚洲高清国产拍精品闺蜜合租| 国产末成年女av片一区二区| 麻豆亚洲一区| 麻豆传煤入口免费进入2023| 琪琪午夜理论片福利在线观看| 国产欧美一区二区精品久久久| а√中文在线资源库| 国产精品高潮呻吟av久久| 女人扒开屁股爽桶30分钟| 少妇粉嫩小泬喷水视频| 国产做a爰片久久毛片a片白丝| 国产99视频精品免费视看6|