在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Zinc finger MYND domain-containing protein 11 (ZMYND11)

Recombinant Human Zinc finger MYND domain-containing protein 11 (ZMYND11)

  • 中文名稱：
    人ZMYND11重組蛋白
  • 貨號：
    CSB-YP621870HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ZMYND11重組蛋白
  • 貨號：
    CSB-EP621870HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人ZMYND11重組蛋白
  • 貨號：
    CSB-EP621870HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人ZMYND11重組蛋白
  • 貨號：
    CSB-BP621870HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ZMYND11重組蛋白
  • 貨號：
    CSB-MP621870HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    ZMYND11
  • Uniprot No.：
  • 別名：
    ZMYND11; BRAM1; BS69; Zinc finger MYND domain-containing protein 11; Adenovirus 5 E1A-binding protein; Bone morphogenetic protein receptor-associated molecule 1; Protein BS69
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區(qū)域：
    1-602
  • 氨基酸序列
    MARLTKRRQA DTKAIQHLWA AIEIIRNQKQ IANIDRITKY MSRVHGMHPK ETTRQLSLAV KDGLIVETLT VGCKGSKAGI EQEGYWLPGD EIDWETENHD WYCFECHLPG EVLICDLCFR VYHSKCLSDE FRLRDSSSPW QCPVCRSIKK KNTNKQEMGT YLRFIVSRMK ERAIDLNKKG KDNKHPMYRR LVHSAVDVPT IQEKVNEGKY RSYEEFKADA QLLLHNTVIF YGADSEQADI ARMLYKDTCH ELDELQLCKN CFYLSNARPD NWFCYPCIPN HELVWAKMKG FGFWPAKVMQ KEDNQVDVRF FGHHHQRAWI PSENIQDITV NIHRLHVKRS MGWKKACDEL ELHQRFLREG RFWKSKNEDR GEEEAESSIS STSNEQLKVT QEPRAKKGRR NQSVEPKKEE PEPETEAVSS SQEIPTMPQP IEKVSVSTQT KKLSASSPRM LHRSTQTTND GVCQSMCHDK YTKIFNDFKD RMKSDHKRET ERVVREALEK LRSEMEEEKR QAVNKAVANM QGEMDRKCKQ VKEKCKEEFV EEIKKLATQH KQLISQTKKK QWCYNCEEEA MYHCCWNTSY CSIKCQQEHW HAEHKRTCRR KR
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Chromatin reader that specifically recognizes and binds histone H3.3 trimethylated at 'Lys-36' (H3.3K36me3) and regulates RNA polymerase II elongation. Does not bind other histone H3 subtypes (H3.1 or H3.2). Colocalizes with highly expressed genes and functions as a transcription corepressor by modulating RNA polymerase II at the elongation stage. Binds non-specifically to dsDNA. Acts as a tumor-suppressor by repressing a transcriptional program essential for tumor cell growth.; (Microbial infection) Inhibits Epstein-Barr virus EBNA2-mediated transcriptional activation and host cell proliferation, through direct interaction.
  • 基因功能參考文獻：
    1. The ZMYND11 gene has important functions in epigenetic regulation. PMID: 28933030
    2. Taken together, ZMYND11 was demonstrated to be a potential and extremely promising suppressor of GBM, while miRNA-196a-5p was quite an important target of treatment of GBM. PMID: 29066350
    3. Interaction with ZMYND11 mediates opposing roles of Ras-responsive ETS1 and ETS2. PMID: 28119415
    4. In this study, we show that this translocation results in an in-frame translocation fusing exon 12 of the tumor suppressor gene ZMYND11 to exon 3 of the chromatin protein MBTD1, encoding a protein of 1,054 amino acids PMID: 26608508
    5. ZMYND11 represses gene expression by binding H3.3K36me3 and preventing transcription elongation. PMID: 24795016
    6. We propose that BS69 specifically associates with H3K36me3-enriched chromatin through the PWWP domain, which facilitates the recruitment of MYND-bound transcription and chromatin remodeling factors PMID: 24675531
    7. this study identifies an H3.3K36me3-specific reader and a regulator of intron retention and reveals that BS69 connects histone H3.3K36me3 to regulated RNA splicing, providing significant, important insights into chromatin regulation of pre-mRNA processing. PMID: 25263594
    8. identification of ZMYND11 as an H3.3-specific reader of H3K36me3 that links the histone-variant-mediated transcription elongation control to tumor suppression PMID: 24590075
    9. BRAM1 acts as a negative signal regulator located at the very proximal end of lymphotoxin beta receptor complex assembly. PMID: 20732415
    10. Data show significant association between the copy number variations of BS69 and some hematological malignancies. PMID: 20425112
    11. Data found that BS69 directly interacted with TRAF3, a negative regulator of NF-kappaB activation. Results revealed that TRAF3 was involved in the BS69-mediated suppression of LMP1/CTAR1-induced NF-kappaB activation. PMID: 20138174
    12. BS69 forms oligomers. The PHD and MYND domains are important for the cellular localization of BS69. PIAS1 and Ubc9 interact with BS69 and promote the sumoylation of BS69. BS69 plays inhibitory roles in both muscle and neuron differentiation. PMID: 19766626
    13. the C-terminal Mynd domain of BS69 (amino acids 516-561) or Mynd domains of the Caenorhabditis elegans proteins Bra-1 and Bra-2 bind not only to E1A but also to the Epstein-Barr virus EBNA2 oncoprotein and the Myc-related cellular protein MGA PMID: 11733528
    14. BS69 controls E1A stability via inhibition of ubiquitination. PMID: 16300738
    15. The recruitment and aggregation of BS69 is a prerequisite for JNK activation by LMP1. PMID: 16382137
    16. BS69 has roles in gene repression and chromatin remodeling PMID: 16565076
    17. Data indicate that BS69 is involved in cellular senescence mainly through the p53-p21Cip1 pathway. PMID: 17721438
    18. Knockdown of BS69 resulted in a decrease of IFN-beta induction, suggesting that BS69 is a positive regulator for the TLR3-TICAM-1 pathway and negative regulatory properties in NF-kappaB activation. PMID: 19795416
    19. The adenovirus E1A binding protein BS69 is a corepressor of transcription through recruitment of N-CoR. PMID: 10734313

    顯示更多

    收起更多

  • 相關(guān)疾?。?/div>
    Mental retardation, autosomal dominant 30 (MRD30)
  • 亞細胞定位：
    Nucleus. Chromosome.
  • 組織特異性：
    Ubiquitous.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 16966

    OMIM: 608668

    KEGG: hsa:10771

    STRING: 9606.ENSP00000371003

    UniGene: Hs.292265



主站蜘蛛池模板： 国产人妻丰满熟妇嗷嗷叫| 国产免费踩踏调教视频| 人禽伦免费交视频播放| 中文在线√天堂| 真人做受试看120分钟小视频| 人妻出差精油按摩被中出| 柠檬福利第一导航在线| 妺妺窝人体色www看美女| 一本色道无码道在线观看| 亚洲乱亚洲乱妇无码麻豆 | 99热久久这里只有精品| 亚洲精品一品区二品区三区| 性按摩无码中文| 噜噜噜亚洲色成人网站∨| 免费观看18禁无遮挡真人网站| 欧美制服丝袜人妻另类| 丝袜足控一区二区三区| 久久综合亚洲色hezyo社区| 曰本丰满熟妇xxxx性| 国产成人毛片无码视频软件| 亚洲狠狠婷婷综合久久久久图片 | 亚洲va无码专区国产乱码| 亚洲精品乱码久久久久久日本麻豆| 欧美日韩国产综合新一区| 99久久免费精品高清特色大片 | 男女吃奶做爰猛烈紧视频| 亚洲精品色播一区二区| 亚洲日韩欧美在线成人| 欧美肥胖老妇bbw| 人妻少妇乱子伦无码专区| 欧美日韩一本的免费高清视频| 国产精品区免费视频| 尤物网址在线观看| 国产成人亚洲综合无码品善网 | 国产亚洲久久久久久久| 国产精品爽爽v在线观看无码| 国产艳妇av在线出轨| 亚洲 欧美 动漫 少妇 自拍| 99久久人妻无码精品系列蜜桃| 好紧好爽好湿别拔出来视频男男| 少妇被粗大的猛进出69影院|