在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Z-DNA-binding protein 1 (ZBP1)

Recombinant Human Z-DNA-binding protein 1 (ZBP1)

  • 中文名稱：
    人ZBP1重組蛋白
  • 貨號：
    CSB-YP861990HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人ZBP1重組蛋白
  • 貨號：
    CSB-BP861990HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人ZBP1重組蛋白
  • 貨號：
    CSB-MP861990HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
  • Uniprot No.：
  • 別名：
    C20orf183; DAI; DLM 1; DLM1; DNA-dependent activator of interferon regulatory factors; DNA-dependent activator of IRFs; OTTHUMP00000031373; OTTHUMP00000174290; OTTHUMP00000237854; Tumor stroma and activated macrophage protein DLM 1; Tumor stroma and activated macrophage protein DLM-1; Z-DNA-binding protein 1; ZBP 1; Zbp1; ZBP1_HUMAN; ZDBP1
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-429
  • 氨基酸序列
    MAQAPADPGR EGHLEQRILQ VLTEAGSPVK LAQLVKECQA PKRELNQVLY RMKKELKVSL TSPATWCLGG TDPEGEGPAE LALSSPAERP QQHAATIPET PGPQFSQQRE EDIYRFLKDN GPQRALVIAQ ALGMRTAKDV NRDLYRMKSR HLLDMDEQSK AWTIYRPEDS GRRAKSASII YQHNPINMIC QNGPNSWISI ANSEAIQIGH GNIITRQTVS REDGSAGPRH LPSMAPGDSS TWGTLVDPWG PQDIHMEQSI LRRVQLGHSN EMRLHGVPSE GPAHIPPGSP PVSATAAGPE ASFEARIPSP GTHPEGEAAQ RIHMKSCFLE DATIGNSNKM SISPGVAGPG GVAGSGEGEP GEDAGRRPAD TQSRSHFPRD IGQPITPSHS KLTPKLETMT LGNRSHKAAE GSHYVDEASH EGSWWGGGI
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death. Once activated upon Z-RNA-binding, ZBP1 interacts with RIPK3, inducing the complementary pathways of apoptosis, necroptosis and pyroptosis. Acts as a key activator of necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members: ZBP1-dependent necroptosis involves RIPK3 stimulation, which phosphorylates and activates MLKL, triggering execution of programmed necrosis. In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol. ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps. In some cell types, also able to restrict viral replication by promoting cell death-independent responses. In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate. Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes.; (Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms hetero-amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit ZBP1-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion.
  • 基因功能參考文獻：
    1. this paper reviews the history and emergence of ZBP1 as a pathogen sensor and a central regulator of cell death and inflammatory responses PMID: 29236673
    2. PUMA promotes the cytosolic release of mitochondrial DNA and activation of the DNA sensors DAI/Zbp1 and STING, leading to enhanced RIP3 and MLKL phosphorylation in a positive feedback loop. PMID: 29581256
    3. There is a correlation between the decrease in DAI-1 receptor expression and the severity of disease progression in preeclampsia. PMID: 29127557
    4. Our results show that HSV2 is detected by a plethora of PRRs including DAI protein which trigger cytokine secretion to protect the host. PMID: 24080302
    5. DAI could function as a DNA sensor and a regulator in DNA-induced macrophage M2b polarization and lupus nephritis. PMID: 23553627
    6. Collectively, these results demonstrate that DAI can suppress HSV-1 growth independent of DNA sensing through mechanisms involving suppression of viral genomes and regulation of ICP0. PMID: 23283962
    7. The data of this study suggest that RNA-binding proteins can be used as a tool to identify the post-transcriptional regulation of gene expression in the establishment and function of neural circuits involved in addiction behaviors. PMID: 22240322
    8. these data indicate that ZBP1 may function as an adapter to export the Ro/Y3 RNA complex from nuclei. PMID: 22114317
    9. Solution structure of the Zbeta domain of human DNA-dependent activator of IFN-regulatory factors and its binding modes to B- and Z-DNAs. PMID: 21471454
    10. hZbeta(DAI) binds to Z-DNA via an active-di B-Z transition mechanism. PMID: 21296080
    11. These results suggest that activation of DAI might contribute to augment HIV-1 replication through DAI- NF-kappaB pathway. PMID: 20599623
    12. identify ZBP1 as being essential for IRF3 activation and interferon beta expression triggered by HCMV, as well as being sufficient to enhance HCMV-stimulated beta interferon transcription and secretion. PMID: 19846511
    13. molecular cloning and structure analysis PMID: 11842111
    14. Z-DNA binding activities of two Zalpha domains in the human ZBP1, hZalpha(ZBP1) and hZbeta(ZBP1)were characterized. PMID: 16448869
    15. In conclusion, intracellular bacteria and cytosolic poly(dA-dT) activate IFNbeta responses in different human cells without requiring human ZBP1. PMID: 18771559
    16. DAI binds to and colocalizes with endogenous adaptor receptor-interacting protein kinase (RIP)1 at characteristic cytoplasmic granules. PMID: 18941233
    17. binding 2 DAIs to 1 dsDNA brings about dimerization of DAI that might facilitate DNA-mediated innate immune activation. PMID: 19095800
    18. These data suggest that repression of ZBP1 by blocking beta-catenin binding at the ZBP1 promoter deregulates its associated mRNAs, leading to the phenotypic changes of breast cancers. PMID: 19461076

    顯示更多

    收起更多

  • 亞細胞定位：
    Cytoplasm. Nucleus.; [Isoform 7]: Cytoplasm. Nucleus.
  • 組織特異性：
    Highly expressed in lymphatic tissues including lymph node, leukocytes, tonsil, bone marrow and spleen. Expressed to a lesser extent in thymus, lung and liver.
  • 數據庫鏈接：

    HGNC: 16176

    OMIM: 606750

    KEGG: hsa:81030

    STRING: 9606.ENSP00000360215

    UniGene: Hs.302123



主站蜘蛛池模板： 久久99精品国产99久久6不卡 | 久久国产劲暴∨内射新川| 日韩精品无码一区二区三区视频| 亚洲人成网站18禁止人| 日韩人妻无码精品系列专区 | 国产精品进线69影院| 午夜视频在线在免费| 国产免费高清69式视频在线观看| 青青草大香焦在线综合视频| 日本老妇人乱xxy| 国产精品国产三级国产an| 国产办公室秘书无码精品99| 人妻少妇精品久久久久久| 欧美野外疯狂做受xxxx高潮| 亚洲精品久久yy5099| 蜜桃mv在线播放免费观看视频| 少妇把腿扒开让我舔18| 国内精品久久久久影院嫩草| 国产精品无码久久综合网| 日韩人妻精品无码一区二区三区| 午夜福利一区二区三区在线观看| 国产成人亚洲精品无码电影| 国产欧美丝袜在线二区| 欧美肥妇bwbwbwbxx| 亚洲色婷婷六月亚洲婷婷6月| 国产午夜精华2020在线| 亚洲国产人在线播放首页| 业余 自由 性别 成熟偷窥| 亚洲第一极品精品无码| 国产制服日韩丝袜86页| 国产精品偷伦视频免费观看了 | 久久av无码精品人妻出轨| 无码gogo大胆啪啪艺术 | 成人无码av网站在线观看| 欧美成人一区二区三区在线观看| 中国凸偷窥xxxx自由视频妇科| 国产午夜鲁丝无码拍拍| 亚洲人成电影免费观看在线看| 亚洲性猛交xxxx| 国产 一二三四五六| 久久精品囯产精品亚洲|