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  4. Recombinant Human Xylosyltransferase 2 (XYLT2), partial

Recombinant Human Xylosyltransferase 2 (XYLT2), partial

  • 中文名稱：
    人XYLT2重組蛋白
  • 貨號：
    CSB-YP884439HU
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人XYLT2重組蛋白
  • 貨號：
    CSB-EP884439HU
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人XYLT2重組蛋白
  • 貨號：
    CSB-EP884439HU-B
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人XYLT2重組蛋白
  • 貨號：
    CSB-BP884439HU
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人XYLT2重組蛋白
  • 貨號：
    CSB-MP884439HU
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    XYLT2
  • Uniprot No.：
  • 別名：
    Peptide O xylosyltransferase 1; Peptide O-xylosyltransferase 1; protein xylosyltransferase 2; PXYLT2; UDP-D-XYLOSE:PROTEOGLYCAN CORE PROTEIN BETA-D-XYLOSYLTRANSFERASE 2; UDP-D-xylose:proteoglycan core protein beta-D-xylosyltransferase; XT II; XT-II; XT2; Xylosyltransferase 2; Xylosyltransferase II; xylT II; XylT-II; XYLT2; XYLT2_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the first step in the biosynthesis of chondroitin sulfate, heparan sulfate and dermatan sulfate proteoglycans, such as DCN. Transfers D-xylose from UDP-D-xylose to specific serine residues of the core protein.
  • 基因功能參考文獻：
    1. mutations in the XYLT2 gene result in a variable phenotype dominated by spinal osteoporosis, cataract, and hearing loss. PMID: 26987875
    2. XYLT2 mutations cause a relatively distinct phenotype, the so-called spondyloocular syndrome. PMID: 27871115
    3. Homozygosity for frameshift mutations in XYLT2 result in a spondylo-ocular syndrome with bone fragility, cataracts, and hearing defects. PMID: 26027496
    4. Demonstrate that XT-II is the predominant isoenzyme responsible for XT activity in serum. The proof was performed using UDP-xylose as the xylose donor, as well as the compound UDP-4-azido-4-deoxyxylose, which is a selective xylose donor for XT-I. PMID: 25748573
    5. Seven XYLT2 promoter single nucleotide variants (SNVs) were identified and genotyped. PMID: 25704086
    6. The study identified and characterized for the first time the XYLT2 gene promoter region and transcription factors involved in its regulation. PMID: 22886070
    7. demonstrate that a soluble form of human XT-II expressed in the xylosyltransferase-deficient pgsA-745 (S745) Chinese hamster ovary cell line is indeed capable of catalyzing the transfer of xylose to a variety of peptide substrates PMID: 17194707
    8. Our data show for the first time that XT-I and XT-II are xylosyltransferases with similar but not identical properties, pointing to their potential role in modulating the cellular proteoglycan pool. PMID: 18023272
    9. Our data show that a XYLT2 haplotype is associated with nephropathy in type 1 diabetic patients PMID: 18789912
    10. The deviation from Hardy-Weinberg equilibrium of two XYLT2 variants might be due to gene-phenotype associations which remain to be explored, as well as the possibility of gene-gene interactions. PMID: 19197251
    11. A protein sequence alignment and polarity plot of XylT-I and XylT-II revealed several Cardin-Weintraub motifs and charged surface clusters, which might be involved in electrostatic-mediated heparin-binding. PMID: 19289103
    12. serum XylT levels may be an informative biomarker in patients who suffer from diseases affecting platelet and/or liver homeostasis. PMID: 19389916

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  • 相關(guān)疾病：
    Spondyloocular syndrome (SOS); Pseudoxanthoma elasticum (PXE)
  • 亞細(xì)胞定位：
    Golgi apparatus membrane; Single-pass type II membrane protein. Secreted.
  • 蛋白家族：
    Glycosyltransferase 14 family, XylT subfamily
  • 組織特異性：
    Widely expressed. Expressed at higher level in kidney and pancreas.
  • 數(shù)據(jù)庫鏈接：

    HGNC: 15517

    OMIM: 264800

    KEGG: hsa:64132

    STRING: 9606.ENSP00000017003

    UniGene: Hs.463416



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