在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Wilms tumor protein 1-interacting protein (WTIP)

  • 中文名稱:
    人WTIP重組蛋白
  • 貨號:
    CSB-YP026161HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人WTIP重組蛋白
  • 貨號:
    CSB-EP026161HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人WTIP重組蛋白
  • 貨號:
    CSB-EP026161HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人WTIP重組蛋白
  • 貨號:
    CSB-BP026161HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人WTIP重組蛋白
  • 貨號:
    CSB-MP026161HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
  • Uniprot No.:
  • 別名:
    WTIP; Wilms tumor protein 1-interacting protein; WT1-interacting protein
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-430
  • 氨基酸序列
    MQRSRAGADE AALLLAGLAL RELEPGCGSP GRGRRGPRPG PGDEAAPALG RRGKGSGGPE AGADGLSRGE RGPRRAAVPE LSAQPAGSPR ASLAGSDGGG GGGSARSSGI SLGYDQRHGS PRSGRSDPRP GPGPPSVGSA RSSVSSLGSR GSAGAYADFL PPGACPAPAR SPEPAGPAPF PLPALPLPPG REGGPSAAER RLEALTRELE RALEARTARD YFGICIKCGL GIYGAQQACQ AMGSLYHTDC FTCDSCGRRL RGKAFYNVGE KVYCQEDFLY SGFQQTADKC SVCGHLIMEM ILQALGKSYH PGCFRCSVCN ECLDGVPFTV DVENNIYCVR DYHTVFAPKC ASCARPILPA QGCETTIRVV SMDRDYHVAC YHCEDCGLQL SGEEGRRCYP LAGHLLCRRC HLRRLQPGPL PSPTVHVTEL
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Adapter or scaffold protein which participates in the assembly of numerous protein complexes and is involved in several cellular processes such as cell fate determination, cytoskeletal organization, repression of gene transcription, cell-cell adhesion, cell differentiation, proliferation and migration. Positively regulates microRNA (miRNA)-mediated gene silencing. Negatively regulates Hippo signaling pathway and antagonizes phosphorylation of YAP1. Acts as a transcriptional corepressor for SNAI1 and SNAI2/SLUG-dependent repression of E-cadherin transcription. Acts as a hypoxic regulator by bridging an association between the prolyl hydroxylases and VHL enabling efficient degradation of HIF1A. In podocytes, may play a role in the regulation of actin dynamics and/or foot process cytoarchitecture. In the course of podocyte injury, shuttles into the nucleus and acts as a transcription regulator that represses WT1-dependent transcription regulation, thereby translating changes in slit diaphragm structure into altered gene expression and a less differentiated phenotype. Involved in the organization of the basal body. Involved in cilia growth and positioning.
  • 基因功能參考文獻:
    1. WTIP interacts with BRCA2 and might be responsible for BRCA2 centrosome localization in cervical cancer cell. PMID: 27535760
    2. Nck1 and Nck2 Interact with WTIP. Nck1/2 integrates nephrin with the Hippo kinase cascade through association with the adaptor protein WTIP. PMID: 27033705
    3. Wtip regulates the stable formation of cell adhesions to both extracellular matrix and neighboring cells and suggest that Wtip is necessary for normal glomerular filtration barrier function PMID: 21900451
    4. Report role of WTIP in regulating podocyte phenotype in chronic kidney disease. PMID: 21686224
    5. Full-length Ror2 recruits Wtip to the cell membrane, a mutant involved in human disease fails to do so. Both genes and proteins show overlapping expression in the mouse embryo. PMID: 19785987
    6. WTIP is a member of the Ajuba family of LIM-domain containing proteins. Ajuba LIM proteins co-repress E-cadherin expression through interaction with the SNAG domain of Snail/Slug and promote epithelial to mesenchymal differentiation in a Xenopus model. PMID: 18331720
    7. Stress signaling pathways initiate WTIP nuclear translocation, and the concomitant loss of WTIP from cell contacts changes podocyte morphology and dynamic actin assembly, suggesting a mechanism that transmits changes in podocyte morphology to the nucleus. PMID: 20086015
    8. WTIP monitors slit diaphragm protein assembly as part of a multiple protein complex, linking this specialized adhesion junction to the actin cytoskeleton, and shuttles into the nucleus after podocyte injury PMID: 14736876

    顯示更多

    收起更多

  • 亞細胞定位:
    Cell junction, adherens junction. Nucleus. Cytoplasm, P-body.
  • 蛋白家族:
    Zyxin/ajuba family
  • 數據庫鏈接:

    HGNC: 20964

    OMIM: 614790

    KEGG: hsa:126374

    STRING: 9606.ENSP00000270288

    UniGene: Hs.585010



主站蜘蛛池模板: 久久9精品区-无套内射无码 | 免费人成视频在线| 欧美人牲口杂交在线播放免费| 男女啪啪无遮挡免费网站| 人妻无码vs中文字幕久久av爆 | 韩国久久久久久级做爰片| 国产高清在线a免费视频观看| 久久国产中文娱乐网| 毛茸茸性xxxx毛茸茸毛茸茸| 久久成人国产精品免费| 午夜人妻理论片天堂影院| 无套内射在线观看theporn| 国产精品丝袜一区二区三区| 精品乱码久久久久久中文字幕| 国产第一页浮力影院入口 | 亚洲精品欧美综合四区| 久九九久视频精品免费| 中国女人高潮hd| 久久久www成人免费毛片| 果冻传媒2021精品一区| av国産精品毛片一区二区视频 | 色又黄又爽18禁免费网站现观看| 一卡二卡3卡4卡视频免费播放| 国产在线观看免费人成视频| 国产精品午夜无码av体验区| 国产猛男猛女超爽免费视频| 国产超碰人人模人人爽人人喊| 久久久久久久精品成人热色戒汤唯 | 99久热re在线精品99 6热视频| 久久久久国产一区二区| 中文字幕av一区乱码| 国产一起色一起爱| 国产亚洲精品aaaa片小说| 无码专区亚洲综合另类| 亚洲乱码中文字幕综合234| 夜夜夜夜猛噜噜噜噜噜| 久久婷婷五月综合色99啪| 亚洲综合小说专区图片| 成人av片在线观看免费| 久久成人a毛片免费观看网站| 国产99在线 | 亚洲|