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  4. Recombinant Human WD repeat-containing protein 81 (WDR81), partial

Recombinant Human WD repeat-containing protein 81 (WDR81), partial

  • 中文名稱：
    人WDR81重組蛋白
  • 貨號：
    CSB-YP701086HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人WDR81重組蛋白
  • 貨號：
    CSB-EP701086HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人WDR81重組蛋白
  • 貨號：
    CSB-EP701086HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人WDR81重組蛋白
  • 貨號：
    CSB-BP701086HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人WDR81重組蛋白
  • 貨號：
    CSB-MP701086HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    WDR81
  • Uniprot No.：
  • 別名：
    WDR81; WD repeat-containing protein 81
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3-phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome. May also play a role in aggrephagy, the macroautophagic degradation of ubiquitinated protein aggregates. In this process, may regulate the interaction of SQSTM1 with ubiquitinated proteins and also recruit MAP1LC3C. May also be involved in maintenance of normal mitochondrial structure and organization.
  • 基因功能參考文獻：
    1. suggest a role for the WDR81-WDR91 complex in the fusion of endolysosomal compartments and the absence of WDR81 leads to impaired receptor trafficking and degradation PMID: 27126989
    2. The WDR81 interacts with LC3C through canonical LC3-interacting regions in the BEACH domain, promoting LC3C recruitment to ubiquitinated proteins. PMID: 28404643
    3. The results of this study suggest that the WDR81 might have a role in mitosis that is conserved between Drosophila and humans. PMID: 28969387
    4. Recessive mutations in WDR81, previously linked to cerebellar ataxia, mental retardation, and disequilibrium syndrome 2, cause severe congenital hydrocephalus. PMID: 28556411
    5. WDR81 mutation is associated with dysequilibrium syndrome type 2 and sensorineural hearing loss. PMID: 26437881
    6. The neuro-ophthalmic examination in CAMRQ2 revealed downbeat nystagmus in all patients, and temporal disc pallor and macular atrophy in two patients. PMID: 22686558

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  • 相關疾?。?/div>
    Cerebellar ataxia, mental retardation, and dysequilibrium syndrome 2 (CAMRQ2)
  • 亞細胞定位：
    Early endosome membrane; Peripheral membrane protein. Late endosome membrane. Lysosome membrane. Cytoplasmic vesicle, autophagosome membrane. Mitochondrion. Cytoplasm, cytosol.
  • 蛋白家族：
    WD repeat WDR81 family
  • 組織特異性：
    Widely expressed. In the brain, highest levels in cerebellum and corpus callosum.
  • 數據庫鏈接：

    HGNC: 26600

    OMIM: 610185

    KEGG: hsa:124997

    STRING: 9606.ENSP00000386609

    UniGene: Hs.234572