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  4. Recombinant Human Vigilin (HDLBP), partial

Recombinant Human Vigilin (HDLBP), partial

  • 中文名稱：
    人HDLBP重組蛋白
  • 貨號：
    CSB-YP010257HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人HDLBP重組蛋白
  • 貨號：
    CSB-EP010257HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人HDLBP重組蛋白
  • 貨號：
    CSB-BP010257HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人HDLBP重組蛋白
  • 貨號：
    CSB-MP010257HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    HDLBP
  • Uniprot No.：
  • 別名：
    HBP; HDL binding protein; HDL-binding protein; HDLBP; high density lipoprotein binding protein; high density lipoprotein binding protein (vigilin); High density lipoprotein-binding protein; PRO2900; VGL; Vigilin; VIGLN_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.
  • 基因功能參考文獻：
    1. Our data reveal that vigilin is essential for maintenance of imprinting of IGF2 gene via functional interaction between KH1-7 domains of vigilin and zinc-finger domains of CTCF. PMID: 29157910
    2. vigilin has been shown to bind over 700 mRNAs and has been associated with cancer progression and cardiovascular disease. PMID: 28975734
    3. this study shows that vigilin (HDLBP) binds and negatively regulates MICB expression through its 5'UTR, and that vigilin downregulation in target cells leads to NK cell activation against said target cells PMID: 28356383
    4. progressively upregulated vigilin may serve as a molecular risk marker for hepatocellular carcinoma development, and targeting vigilin may help to inhibit hepatocellular carcinoma cell growth, survival and migration. PMID: 24676454
    5. CTCF may regulate vigilin behavior and thus indirectly influence the binding of HP1alpha to the satellite 2 locus PMID: 24561205
    6. Vigilin may have a relationship with hepatocellular carcinoma progression and proliferation. PMID: 21500547
    7. identified a competition for binding the 69-nt sequence, through which vigilin and HuR exert opposing effects on c-fms expression, suggesting a role for vigilin in suppression of breast cancer progression PMID: 20974809
    8. Expression profiles of human VIGILIN, H19, and IGF2 mRNA increased with cell-cycle prograssion. PMID: 19950580
    9. RNA interference studies indicate vigilin is essential for cell viability but is not a global regulator of translation. PMID: 14500828
    10. evidence that vigilin is bound to the ribosomal complex. PMID: 15109574
    11. C-terminal domain of human vigilin binds to the histone methyltransferase SUV39H1 in vivo;a new model for vigilin-mediated, RNA-induced gene silencing is presented. PMID: 18648073

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  • 亞細胞定位：
    Cytoplasm. Nucleus.
  • 數據庫鏈接：

    HGNC: 4857

    OMIM: 142695

    KEGG: hsa:3069

    STRING: 9606.ENSP00000312042

    UniGene: Hs.471851



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