在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Vascular endothelial growth factor B (VEGFB)

Recombinant Human Vascular endothelial growth factor B (VEGFB)

  • 中文名稱：
    人VEGFB重組蛋白
  • 貨號：
    CSB-EP025834HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人VEGFB重組蛋白
  • 貨號：
    CSB-EP025834HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人VEGFB重組蛋白
  • 貨號：
    CSB-BP025834HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人VEGFB重組蛋白
  • 貨號：
    CSB-MP025834HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    Greater than 85% as determined by SDS-PAGE.
  • 基因名：
  • Uniprot No.：
  • 別名：
    Vascular endothelial growth factor B; Vascular endothelial growth factor-related factor; VEGF B; VEGF related factor; VEGF-B; VEGF-related factor; Vegfb; VEGFB_HUMAN; VEGFL; VRF
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Full Length of Mature Protein
  • 表達區域：
    22-207aa
  • 氨基酸序列
    PVSQPDAPGHQRKVVSWIDVYTRATCQPREVVVPLTVELMGTVAKQLVPSCVTVQRCGGCCPDDGLECVPTGQHQVRMQILMIRYPSSQLGEMSLEEHSQCECRPKKKDSAVKPDRAATPHHRPQPRSVPGWDSAPGAPSPADITHPTPAPGPSAHAAPSTTSALTPGPAAAAADAAASSVAKGGA
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Growth factor for endothelial cells. VEGF-B167 binds heparin and neuropilin-1 whereas the binding to neuropilin-1 of VEGF-B186 is regulated by proteolysis.
  • 基因功能參考文獻：
    1. High plasma VEGF-B levels are associated with type 2 diabetes mellitus. PMID: 28523459
    2. Data from clinical studies point out the changes in circulating or tissue expression levels of VEGF-B in obese compared with lean patients. PMID: 28798193
    3. Cardiac transgenic vascular endothelial growth factor-B overexpression failed to protect heart transplants from ischemia-reperfusion injury. PMID: 27588416
    4. renal VEGF-B expression correlates with the severity of Diabetic Kidney Disease. PMID: 28190774
    5. Data show that metformin treatment reduces serum vascular endothelial growth factor B (VEGF-B) levels and ameliorates insulin resistance. PMID: 26387747
    6. Frameshift mutations of VEGFB gene is associated with stomach and colorectal cancers. PMID: 25633991
    7. fluid shear stress induces the synthesis of Insulin growth factor-2 and vascular endothelial growth factor (VEGF) B and D, which in turn transactivate MMP-12. PMID: 25435370
    8. MMP9 may activate VEGF-B via PI3K/Akt signaling pathway. PMID: 25424698
    9. Roles of vascular endothelial growth factor in amyotrophic lateral sclerosis. PMID: 24987705
    10. Low VEGFB and VEGFD gene expression is associated with early-stage non-small cell lung cancer. PMID: 24145997
    11. Our study suggested that VEGF-B was an angiogenesis factor in vitro and that ERK1/2 and p38-related signaling pathways were involved in these VEGF-B activities. PMID: 24374930
    12. VEGF-B has possible roles in cardiac protection, energy metabolism support, and neuroprotectin [review] PMID: 24987005
    13. High VEGF-B levels might correlate with the presence of hyperlipidemia and target organ damage in type 2 diabetic patients. PMID: 25001655
    14. High VEGFB expression is associated with bone marrow metastasis in neuroblastoma. PMID: 23553333
    15. VEGF-B might be an important ligand in the signalling between the tumor and preexisting blood vessels to ensure a functional blood supply for tumor survival. PMID: 23417498
    16. we report significant associations with overall survival and distant failure for certain VEGF(VEGF-B) family members. PMID: 23728940
    17. Data indicate that three miRs (miR-484, -642, and -217) were able to predict chemoresistance and vasculature of serous epithelial ovarian carcinomas through the regulation of the VEGFB and VEGFR2 pathways. PMID: 23697367
    18. Expression of VEGF-B genes in glioma cell lines U87 is significantly changed under hypoxia and ischemic conditions. PMID: 23350126
    19. In WT1 mutant cells, reduced VEGF(165)b was due to lack of WT1-mediated transcriptional repression of the splicing-factor kinase SRPK1 PMID: 22172722
    20. analysis of binding of vascular endothelial growth factor-B by VEGFR-1(D2) PMID: 20501651
    21. TIMP3 blocks the binding of VEGF to VEGF receptor-2 and inhibits downstream signaling and angiogenesis. PMID: 12652295
    22. Results describe the crystal structure of human vascular endothelial growth factor-B (VEGF-B) and present a predicted model for the association of VEGF-B with the second domain of its receptor, VEGFR-1. PMID: 16616187
    23. Basophils could play a role in angiogenesis and inflammation through the expression of several forms of VEGF-B and their receptors. PMID: 17082651
    24. VEGFB, and receptor were highly expressed in dysplastic neurons. IR in astroglial and balloon cells was observed for VEGFA and its receptors Double-labeling also showed expression of VEGFA, VEGFB and VEGFR-1 in cells of the microglia/macrophage lineage. PMID: 18317782
    25. VEGF-B appears to have a relatively restricted angiogenic activity in the ischemic heart. PMID: 18511699
    26. Increased VEGFB expression is associated with hepatocellular carcinoma PMID: 18537151
    27. Overexpression of vascular endothelial growth factor-B in mouse heart alters cardiac lipid metabolism and induces myocardial hypertrophy. PMID: 18757827
    28. The structural features of the 'highly ordered' interaction of the Fab fragment of the antibody (Fab-2H10) with VEGF-B, is presented. PMID: 18930733
    29. VEGF-B mRNA was not expressed either in normal urothelium or in bladder cancer. PMID: 19424629

    顯示更多

    收起更多

  • 亞細胞定位：
    Secreted. Note=Secreted but remains associated to cells or to the extracellular matrix unless released by heparin.
  • 蛋白家族：
    PDGF/VEGF growth factor family
  • 組織特異性：
    Expressed in all tissues except liver. Highest levels found in heart, skeletal muscle and pancreas.
  • 數據庫鏈接：

    HGNC: 12681

    OMIM: 601398

    KEGG: hsa:7423

    STRING: 9606.ENSP00000311127

    UniGene: Hs.732095



主站蜘蛛池模板： 中文无码精品a∨在线观看不卡| 国产高清在线精品一区免费| 大肉大捧一进一出好爽视色大师 | 精品人伦一区二区三区潘金莲| 久久 国产 尿 小便 嘘嘘| 亚洲丁香婷婷综合久久| 中国美女牲交视频| 超碰免费公开| 色欲av伊人久久大香线蕉影院| 风韵饥渴少妇在线观看| 亚洲中文字幕人成乱码| 国产在线精品一区二区三区| аⅴ天堂中文在线网| 伊人久久大香线蕉综合直播| 亚洲精品无码精品mv在线观看 | 国精品无码人妻一区二区三区 | 女被啪到深处喷水gif动态图| 日韩国产综合精选| 鲁大师影院在线观看| 九九视频在线观看视频6| 麻豆熟妇人妻xxxxxx| 亚洲a片成人无码久久精品色欲| 亚洲国产精品无码久久久不卡| 抽插丰满内射高潮视频| 国产精品高潮呻吟av久久4虎| 精品服丝袜无码视频一区| 亚洲最大的熟女水蜜桃av网站 | 亚洲欧美国产va在线播放| 夜先锋av资源网站| 性一交一乱一伧国产女士spa| 国产精品国产自线拍免费不卡| 无码熟妇人妻av在线网站| 免费观看的av毛片的网站| 十八禁视频网站在线观看| 18处破外女出血在线| 久久www成人免费直播| 啦啦啦www在线观看免费视频| 国产成人午夜福利在线观看| 国产免费福利在线视频| 好吊妞人成视频在线观看27du| 一色屋精品视频在线观看|