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  4. Recombinant Human Undifferentiated embryonic cell transcription factor 1 (UTF1)

Recombinant Human Undifferentiated embryonic cell transcription factor 1 (UTF1)

  • 中文名稱：
    人UTF1重組蛋白
  • 貨號：
    CSB-YP025760HU
  • 說明書：
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人UTF1重組蛋白
  • 貨號：
    CSB-EP025760HU
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人UTF1重組蛋白
  • 貨號：
    CSB-EP025760HU-B
  • 說明書：
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人UTF1重組蛋白
  • 貨號：
    CSB-BP025760HU
  • 說明書：
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人UTF1重組蛋白
  • 貨號：
    CSB-MP025760HU
  • 說明書：
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    UTF1
  • Uniprot No.：
  • 別名：
    hUTF 1; hUTF1; Undifferentiated embryonic cell transcription factor 1; UTF 1; UTF1; UTF1_HUMAN
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    full length protein
  • 表達區域：
    1-341
  • 氨基酸序列
    MLLRPRRPPP LAPPAPPSPA SPDPEPRTPG DAPGTPPRRP ASPSALGELG LPVSPGSAQR TPWSARETEL LLGTLLQPAV WRALLLDRRQ ALPTYRRVSA ALAQQQVRRT PAQCRRRYKF LKDKFREAHG QPPGPFDEQI RKLMGLLGDN GRKRPRRRSP GSGRPQRARR PVPNAHAPAP SEPDATPLPT ARDRDADPTW TLRFSPSPPK SADASPAPGS PPAPAPTALA TCIPEDRAPV RGPGSPPPPP AREDPDSPPG RPEDCAPPPA APPSLNTALL QTLGHLGDIA NILGPLRDQL LTLNQHVEQL RGAFDQTVSL AVGFILGSAA AERGVLRDPC Q
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Acts as a transcriptional coactivator of ATF2.
  • 基因功能參考文獻：
    1. With a sensitivity of 100% and a specificity of 97% in the detection of central nervous system (CNS) germinomas, UTF1 serves as a new reliable alternative in the diagnostic setting of CNS germ cell tumours. PMID: 24614704
    2. UTF1 attenuates cell proliferation and is inactivated in cervical carcinogenesis through epigenetic modification. PMID: 23536577
    3. These findings strongly suggest that UTF1 promoter methylation profile might be a useful biomarker for cervical cancer diagnosis. PMID: 22880087
    4. Utf1 couples the core pluripotency factors with Myc and PRC2 networks to promote the pluripotency and proliferation of embryonic stem cells. PMID: 23101626
    5. role for UTF1 in differentiation of matrix cells of the shaft as well as in suprabasal keratinocytes. PMID: 21446939
    6. Human UTF1 is a tightly DNA-associated protein with transcriptional repressor activity. PMID: 19393592
    7. Strong UTF1 staining can be used for diagnosing embryonal carcinoma and seminoma. UTF1 expression in spermatogonia suggests its possible role in spermatogenesis and renewal of spermatogonia. PMID: 20855642
    8. Single SNPs did not alter the chromatin association and mobility of hUTF1; however, the double mutant, G73R/L275M, demonstrated a decreased chromatin association, indicating a degree of protein malfunction. PMID: 20218897
    9. The expression pattern indicated that UTF-1 plays a possible role in spermatogonial self-renewal PMID: 18281244
    10. enhances reprogramming efficiency of pluripotent stem cells generation induced from human adult fibroblasts PMID: 18983962

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  • 亞細胞定位：
    Nucleus.
  • 數據庫鏈接：

    HGNC: 12634

    OMIM: 604130

    KEGG: hsa:8433

    STRING: 9606.ENSP00000305906

    UniGene: Hs.458406



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