在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Unconventional myosin-Ic (MYO1C), partial

Recombinant Human Unconventional myosin-Ic (MYO1C), partial

  • 中文名稱：
    人MYO1C重組蛋白
  • 貨號：
    CSB-YP015340HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人MYO1C重組蛋白
  • 貨號：
    CSB-EP015340HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人MYO1C重組蛋白
  • 貨號：
    CSB-EP015340HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人MYO1C重組蛋白
  • 貨號：
    CSB-BP015340HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人MYO1C重組蛋白
  • 貨號：
    CSB-MP015340HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    MYO1C
  • Uniprot No.：
  • 別名：
    MMI beta; MMI-beta; MMIb; MYO1C; MYO1C_HUMAN; Myosin I beta; Myosin Ic; Myosin-Ic; MYR2; NMI; Nuclear myosin I
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標(biāo)簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder Warning: in_array() expects parameter 2 to be array, null given in /www/web/cusabio_cn/public_html/caches/caches_template/default/content/show_product_protein.php on line 662
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復(fù)溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

相關(guān)產(chǎn)品

靶點詳情

  • 功能：
    Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes.; Isoform 3 is involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation.
  • 基因功能參考文獻(xiàn)：
    1. E2 and NM1 associate via their N-terminal domains and this interaction is ATP dependent. PMID: 29179037
    2. The results establish a mechanistic connection between the calcium regulation of the motor function of myosin IC in the cytoplasm and the induction of its import into the nucleus. PMID: 27192697
    3. NTR(35), which harbors the R21G mutation, was unable to confer MYO1C(35)-like kinetic behavior. Thus, the NTRs affect the specific nucleotide-binding properties of MYO1C isoforms, adding to their kinetic diversity. We propose that this level of fine-tuning within MYO1C broadens its adaptability within cells. PMID: 28893906
    4. Cells expressing excess of MYO1C had low basal level of phosphorylated protein kinase B. PMID: 27716847
    5. Upon DNA damage, an increase in the levels of chromatin bound motor protein nuclear myosin 1 (NM1) ensues, which appears to be functionally linked to Upsilon-H2AX signaling. PMID: 27365048
    6. Study presents structural demonstration of a cargo protein, Neph1, attached to Myo1c, providing novel insights into the role of Myo1c in intracellular movements of this critical slit diaphragm protein. PMID: 27044863
    7. In glioblastoma 1321 N1 cells, we recently identified Myo1c as a new interactor of SHIP2. SHIP2 localization at lamellipodia and ruffles is impaired in Myo1c depleted cells. In the absence of Myo1c, N1 cells tend to associate to form clusters. PMID: 27246739
    8. Overexpression of MYO1C is associated with gastric cancer. PMID: 27468717
    9. Ablating MYO1C function causes abnormal cholesterol distribution, which has a major selective impact on the autophagy pathway PMID: 25551774
    10. Myo1c significantly increases the frequency of kinesin-1-driven microtubule-based runs that begin at actin/microtubule intersections. The actin-binding protein tropomyosin 2 abolishes Myo1c-specific effects on both run initiation and run termination. PMID: 25660542
    11. NM1 phosphorylation by GSK3beta blocks NM1 ubiquitination by UBR5 and degradation by the proteasome, leads to NM1 association with the chromatin and promotes rDNA transcription activation at G1. PMID: 24901984
    12. The relationship between MYO1C and KAT6B suggests that the two are interacting in chromatin remodelling for gene expression in human masseter muscle. This is the nuclear myosin1 (NM1) function of MYO1C. PMID: 24698832
    13. myosin 1c manipulations lead to loss of the actin filaments and to similar endoplasmic reticulum phenotype as observed after actin depolymerization. PMID: 24523293
    14. The structural context and the chemical environment of Myo1c mutations that are involved in sensorineural hearing loss in humans are described and their impact on motor function is discussed. PMID: 24636949
    15. These results suggest a unique structural role for NM1 in which the interaction with SNF2h stabilizes B-WICH at the gene promoter and facilitates recruitment of the HAT PCAF PMID: 23555303
    16. Both nucleolar localization signals are functional and necessary for nucleolar localization of specifically myosin IC isoform B. PMID: 23438938
    17. This is the first report demonstrating that Myo1c is an important mediator of VEGF-induced VEGFR2 delivery to the cell surface and plays a role in angiogenic signaling. PMID: 23262137
    18. Myo1c regulates lipid raft recycling to control cell spreading, migration and Salmonella invasion. PMID: 22328521
    19. Myo1c plays a critical role in the translocation of Neph1 complexes in podocytes. Myo1c's ability to interact with membranes, F-actin, Neph1, and nephrin indicates that it actively contributes to the dynamic organization of the filtration slit. PMID: 21402783
    20. NM1 facilitates maturation and accompanies export-competent preribosomal subunits to the nuclear pore complex, thus modulating export. PMID: 19729515
    21. NM1 cooperates with a chromatin remodelling complex containing WSTF (Williams syndrome transcription factor) and SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily A member 5 protein (SNF2h). PMID: 16514417
    22. WSTF-SNF2h-NM1 forms a platform in transcription while providing chromatin remodeling PMID: 16603771

    顯示更多

    收起更多

  • 亞細(xì)胞定位：
    [Isoform 1]: Cytoplasm. Nucleus.; [Isoform 3]: Nucleus, nucleoplasm. Nucleus, nucleolus. Nucleus, nuclear pore complex.
  • 蛋白家族：
    TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 7597

    OMIM: 606538

    KEGG: hsa:4641

    STRING: 9606.ENSP00000352834

    UniGene: Hs.286226



主站蜘蛛池模板： 日韩69永久免费视频| 人妻妺妺窝人体色www聚色窝| 婷婷六月丁香缴 清| 双乳被一左一右吃着动态图| 2022国产日产欧产精品| 性一交一乱一伦一色一情孩交| 国产欧美另类久久精品蜜芽| 亚洲高清无码加勒比| 强 暴 疼 哭 处 女 身子视频| 亚洲色大成网站www久久九| 妺妺窝人体色www在线小说| 国产精品亚洲综合久久系列| 成人免费午夜无码视频| 蜜臀av无码精品人妻色欲| 日日摸天天摸爽爽狠狠97| 大j8黑人w巨大888a片| 亚洲伊人久久成人综合网| 久久人妻av无码中文专区| 亚洲精品国产精品乱码不99| 亚洲乱色伦图片区小说| 好爽好硬好深高潮视频456| 丁香花在线影院观看在线播放| 国产黑色丝袜在线观看下| 久久精品人人做人人综合试看| 人妻少妇av中文字幕乱码| 久久久www免费人成精品| 18禁黄网站禁片无遮挡观看 | 欧美巨大巨粗黑人性aaaaaa| 国产精品岛国久久久久| 免费va国产高清大片在线| 欧美激欧美啪啪片| 国产精品久久久久久无毒不卡| 欧美成人va免费大片视频| 亚洲 卡通 欧美 制服 中文| 亚洲成a人片在线观看无码| 国产v亚洲v天堂无码久久久| 无码高潮喷吹在线观看| 2020无码天天喷水天天爽| 一区二区乱子伦在线播放| 无码h肉动漫在线观看免费| av无码不卡一区二区三区|