在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 12 (USP12)

  • 中文名稱:
    人USP12重組蛋白
  • 貨號:
    CSB-YP025699HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人USP12重組蛋白
  • 貨號:
    CSB-EP025699HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人USP12重組蛋白
  • 貨號:
    CSB-EP025699HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人USP12重組蛋白
  • 貨號:
    CSB-BP025699HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人USP12重組蛋白
  • 貨號:
    CSB-MP025699HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    USP12
  • Uniprot No.:
  • 別名:
    Deubiquitinating enzyme 12; OTTHUMP00000042337; UBH 1; UBH1; Ubiquitin carboxyl terminal hydrolase 12; Ubiquitin carboxyl-terminal hydrolase 12; Ubiquitin hydrolyzing enzyme 1; Ubiquitin specific peptidase 12; Ubiquitin specific processing protease 12; Ubiquitin specific protease 12 like 1; Ubiquitin thioesterase 12; Ubiquitin thiolesterase 12; Ubiquitin-hydrolyzing enzyme 1; Ubiquitin-specific-processing protease 12; UBP12_HUMAN; USP 12; Usp12; USP12L1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-370
  • 氨基酸序列
    MEILMTVSKF ASICTMGANA SALEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC RPFREKVLAY KSQPRKKESL LTCLADLFHS IATQKKKVGV IPPKKFITRL RKENELFDNY MQQDAHEFLN YLLNTIADIL QEERKQEKQN GRLPNGNIDN ENNNSTPDPT WVHEIFQGTL TNETRCLTCE TISSKDEDFL DLSVDVEQNT SITHCLRGFS NTETLCSEYK YYCEECRSKQ EAHKRMKVKK LPMILALHLK RFKYMDQLHR YTKLSYRVVF PLELRLFNTS GDATNPDRMY DLVAVVVHCG SGPNRGHYIA IVKSHDFWLL FDDDIVEKID AQAIEEFYGL TSDISKNSES GYILFYQSRD
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability.
  • 基因功能參考文獻:
    1. Usp12 deubiquitylates and prevents lysosomal degradation of LAT and Trat1 to maintain the proximal TCR complex for the duration of signaling. PMID: 26811477
    2. Usp12 directly deubiquitinates and stabilises the Akt phosphatases PHLPP and PHLPPL resulting in decreased levels of active pAkt. PMID: 25216524
    3. our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival PMID: 24145035
    4. Usp12 acts in a pro-proliferative manner by stabilizing AR and enhancing its cellular function. PMID: 24056413
    5. The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. PMID: 22778262

    顯示更多

    收起更多

  • 蛋白家族:
    Peptidase C19 family, USP12/USP46 subfamily
  • 數據庫鏈接:

    HGNC: 20485

    OMIM: 603091

    KEGG: hsa:219333

    STRING: 9606.ENSP00000282344

    UniGene: Hs.42400



主站蜘蛛池模板: 久久精品成人欧美大片| 7m精品福利视频导航| 人妻熟女一区二区aⅴ清水理纱| 国产桃色无码视频在线观看| 美女高潮黄又色高清视频免费| 300部国产真实乱| 18岁日韩内射颜射午夜久久成人| 欧美成人精品三级网站| 熟女人妻少妇精品视频| 久久综合久久综合九色| 中日韩精品无码一区二区三区| 久久精品99久久香蕉国产色戒| 久久久久久亚洲综合影院| 免费无码av片在线观看潮喷| 四虎国产成人永久精品免费| 欧美多毛肥胖老妇做爰| 少妇无码精油按摩专区| 中文字幕在线观看亚洲日韩| 亚洲中文精品久久久久久| 国产成人无码18禁午夜福利网址| 精品深夜av无码一区二区老年 | 韩国19禁主播深夜福利视频| 日韩欧美一区二区三区免费观看| 亚洲精品久久av无码麻| 国产线观看免费观看| 妺妺窝人体色www聚色窝仙踪| 国产又黄又大又粗视频| 最近中文字幕mv在线视频看| 国产在线观看黄av免费| 久久天天躁狠狠躁夜夜av | 亚洲精品久久久狠狠爱小说| 蜜柚av久久久久久久| 无码东京热一区二区三区| 国产精品狼人久久久久影院| 欧美 国产 综合 欧美 视频| 亚洲乱亚洲乱妇50p| 国产狂喷潮在线观看中文| 亚洲最大成人网 色香蕉| 日本一道一区二区视频| 18禁黄网站禁片免费观看国产| 亚洲欧美中文字幕5发布|