在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Ubiquitin carboxyl-terminal hydrolase 12 (USP12)

  • 中文名稱:
    人USP12重組蛋白
  • 貨號:
    CSB-YP025699HU
  • 規格:
  • 來源:
    Yeast
  • 其他:
  • 中文名稱:
    人USP12重組蛋白
  • 貨號:
    CSB-EP025699HU
  • 規格:
  • 來源:
    E.coli
  • 其他:
  • 中文名稱:
    人USP12重組蛋白
  • 貨號:
    CSB-EP025699HU-B
  • 規格:
  • 來源:
    E.coli
  • 共軛:
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他:
  • 中文名稱:
    人USP12重組蛋白
  • 貨號:
    CSB-BP025699HU
  • 規格:
  • 來源:
    Baculovirus
  • 其他:
  • 中文名稱:
    人USP12重組蛋白
  • 貨號:
    CSB-MP025699HU
  • 規格:
  • 來源:
    Mammalian cell
  • 其他:

產品詳情

  • 純度:
    >85% (SDS-PAGE)
  • 基因名:
    USP12
  • Uniprot No.:
  • 別名:
    Deubiquitinating enzyme 12; OTTHUMP00000042337; UBH 1; UBH1; Ubiquitin carboxyl terminal hydrolase 12; Ubiquitin carboxyl-terminal hydrolase 12; Ubiquitin hydrolyzing enzyme 1; Ubiquitin specific peptidase 12; Ubiquitin specific processing protease 12; Ubiquitin specific protease 12 like 1; Ubiquitin thioesterase 12; Ubiquitin thiolesterase 12; Ubiquitin-hydrolyzing enzyme 1; Ubiquitin-specific-processing protease 12; UBP12_HUMAN; USP 12; Usp12; USP12L1
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full length protein
  • 表達區域:
    1-370
  • 氨基酸序列
    MEILMTVSKF ASICTMGANA SALEKEIGPE QFPVNEHYFG LVNFGNTCYC NSVLQALYFC RPFREKVLAY KSQPRKKESL LTCLADLFHS IATQKKKVGV IPPKKFITRL RKENELFDNY MQQDAHEFLN YLLNTIADIL QEERKQEKQN GRLPNGNIDN ENNNSTPDPT WVHEIFQGTL TNETRCLTCE TISSKDEDFL DLSVDVEQNT SITHCLRGFS NTETLCSEYK YYCEECRSKQ EAHKRMKVKK LPMILALHLK RFKYMDQLHR YTKLSYRVVF PLELRLFNTS GDATNPDRMY DLVAVVVHCG SGPNRGHYIA IVKSHDFWLL FDDDIVEKID AQAIEEFYGL TSDISKNSES GYILFYQSRD
  • 蛋白標簽:
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式:
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet :
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Deubiquitinating enzyme. Has almost no deubiquitinating activity by itself and requires the interaction with WDR20 and WDR48 to have a high activity. Not involved in deubiquitination of monoubiquitinated FANCD2. In complex with WDR48, acts as a potential tumor suppressor by positively regulating PHLPP1 stability.
  • 基因功能參考文獻:
    1. Usp12 deubiquitylates and prevents lysosomal degradation of LAT and Trat1 to maintain the proximal TCR complex for the duration of signaling. PMID: 26811477
    2. Usp12 directly deubiquitinates and stabilises the Akt phosphatases PHLPP and PHLPPL resulting in decreased levels of active pAkt. PMID: 25216524
    3. our results reveal WDR48 and USP12 as novel PHLPP1 regulators and potential suppressors of tumor cell survival PMID: 24145035
    4. Usp12 acts in a pro-proliferative manner by stabilizing AR and enhancing its cellular function. PMID: 24056413
    5. The ubiquitin-specific protease 12 (USP12) is a negative regulator of notch signaling acting on notch receptor trafficking toward degradation. PMID: 22778262

    顯示更多

    收起更多

  • 蛋白家族:
    Peptidase C19 family, USP12/USP46 subfamily
  • 數據庫鏈接:

    HGNC: 20485

    OMIM: 603091

    KEGG: hsa:219333

    STRING: 9606.ENSP00000282344

    UniGene: Hs.42400



主站蜘蛛池模板: 国产老熟女老女人老人| 久久婷婷色综合一区二区| 国产欧美久久一区二区| 少妇精品导航| 98视频精品全部国产| 国产成人精品视频国产| 亚洲免费观看视频| 无套内谢老熟女| 中文乱码人妻系列一区| 亚洲乱码卡一卡二卡新区仙踪木木| 天堂无码人妻精品av一区| 精品人妻av一区二区三区| 永久免费的av片在线电影网| 午夜免费啪视频在线观看区 | 日本丶国产丶欧美色综合| 国产精品美女被遭强扒开双腿| 一本久久综合亚洲鲁鲁五月天| 国精品人妻无码一区二区三区蜜柚| 乱码国产丰满人妻www| 十八禁裸体www网站免费观看| 亚洲熟妇中文字幕日产无码| 亚洲精品四区麻豆文化传媒| 日本少妇被黑人猛cao| 少妇高潮惨叫久久久久久| 国产成人无码a区在线| av无码国产在线看免费网站| 天堂…中文在线最新版在线| 99久久久无码国产精品性| 饥渴少妇做私密保健视频| 日日日日做夜夜夜夜无码| 毛片内射久久久一区| 朝鲜女人大白屁股ass| 曰本一道本久久88不卡| 2020精品国产户外| 亚洲精品美女久久7777777| 国产免费人成视频尤勿视频| 国产片a国产片免费看视频| 天天躁日日躁aaaaxxxx| 欧洲精品码一区二区三区| 久久久久国产精品人妻aⅴ天堂| 亚洲一区精品无码色成人|