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  4. Recombinant Human UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1), partial

Recombinant Human UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase (DPAGT1), partial

  • 中文名稱：
    人DPAGT1重組蛋白
  • 貨號：
    CSB-YP884460HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
    人DPAGT1重組蛋白
  • 貨號：
    CSB-EP884460HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
    人DPAGT1重組蛋白
  • 貨號：
    CSB-EP884460HU-B
  • 說明書：
  • 規(guī)格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
    人DPAGT1重組蛋白
  • 貨號：
    CSB-BP884460HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
    人DPAGT1重組蛋白
  • 貨號：
    CSB-MP884460HU
  • 說明書：
  • 規(guī)格：
  • 來源：
    Mammalian cell
  • 其他：

產(chǎn)品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    DPAGT1
  • Uniprot No.：
  • 別名：
    ALG7; AU021132; CDG Ij; CDG1J; CMS13; CMSTA2; D11S366; DGPT; Dolichyl phosphate (UDP N acetylglucosamine) acetylglucosaminephosphotransferase 1 (GlcNAc 1 P transferase); Dolichyl-phosphate N-acetylglucosaminephosphotransferase 1; DPAGT1; DPAGT2; G1PT; GlcNAc 1 P transferase 1; GlcNAc-1-P transferase; Gnpta; GPT; GPT_HUMAN; H2afx; N-acetylglucosamine-1-phosphate transferase; UAGT; UDP GlcNAc:dolichyl phosphate N acetylglucosaminephosphotransferase; UDP N acetylglucosamine dolichyl phosphate N acetylglucosaminephosphotransferase 1; UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase; UGAT
  • 種屬：
    Homo sapiens (Human)
  • 蛋白長度：
    Partial
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產(chǎn)品提供形式：
    Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質(zhì)期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產(chǎn)品評價

靶點詳情

  • 功能：
    Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.
  • 基因功能參考文獻：
    1. present work improves our knowledge of DPAGT1-CDG and provides bases for developing tailored splicing and folding therapies PMID: 28662078
    2. Data suggest that N-acetylglucosaminyl 1-phosphate transferase is a breast cancer therapeutic target. PMID: 25408354
    3. Studies show that cells coordinate DPAGT1 expression and protein N-glycosylation with canonical Wnt signaling and E-cadherin adhesion via positive and negative feedback mechanisms. PMID: 23178939
    4. prominent limb-girdle weakness and minimal craniobulbar symptoms who harbour a novel mutation in DPAGT1 PMID: 23591138
    5. Patients with DPAGT1 CMS share similar clinical features with patients who have CMS caused by mutations in GFPT1, another recently identified CMS subtype. PMID: 23447650
    6. Results indicate that the clinical spectrum of dolichyl-phosphate alpha-N-acetylglucosaminyltransferase (DPAGT1)-congenital disorders of glycosylation (CDG) is much broader than appreciated so far. PMID: 23249953
    7. Data suggest that in oral squamous cell carcinoma (OSCC), dysregulation of canonical Wnt signaling and DPAGT1-dependent N-glycosylation induces CTHRC1, thereby driving OSCC cell migration and tumor spread. PMID: 23703614
    8. suggest that the primary pathogenic mechanism of DPAGT1-associated CMS is reduced levels of AChRs at the endplate region. This finding demonstrates that impairment of the N-linked glycosylation pathway can lead to the development of CMS PMID: 23278575
    9. Overexpression of DPAGT1 in human oral squamous cell carcinoma specimens is linked to aberrant activation of canonical Wnt signaling. PMID: 22341307
    10. We identify DPAGT1 as a gene in which mutations cause a congenital myasthenic syndrome. PMID: 22742743
    11. Mutations in DPAGT1 gene is associated with Congenital disorder of glycosylation type Ij. PMID: 22304930
    12. up-regulation of DPAGT1 transcripts by Wnt3a led to altered N-glycosylation of E-cadherin. PMID: 20693288
    13. REVIEW: Structure, expression, and regulation PMID: 19519349
    14. Studies show for the first time that DPAGT1 is an upstream regulator of E-cadherin N-glycosylation status and adherens junction composition and suggest that dysregulation of DPAGT1 causes disturbances in intercellular adhesion in oral cancer. PMID: 19549906

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  • 相關疾病：
    Congenital disorder of glycosylation 1J (CDG1J); Myasthenic syndrome, congenital, 13 (CMS13)
  • 亞細胞定位：
    Endoplasmic reticulum membrane; Multi-pass membrane protein.
  • 蛋白家族：
    Glycosyltransferase 4 family
  • 數(shù)據(jù)庫鏈接：

    HGNC: 2995

    OMIM: 191350

    KEGG: hsa:1798

    STRING: 9606.ENSP00000346142

    UniGene: Hs.524081



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