在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)

In Stock
  • 中文名稱:
    Recombinant Human Tumor necrosis factor receptor type 1-associated DEATH domain protein (TRADD)
  • 貨號:
    CSB-EP621879HUc7
  • 規(guī)格:
    ¥1836
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 生物活性:
    Not Test
  • 基因名:
  • Uniprot No.:
  • 別名:
    TNFR1-associated DEATH domain protein;TNFRSF1A-associated via death domain
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Full Length
  • 來源:
    E.coli
  • 分子量:
    41.2 kDa
  • 表達區(qū)域:
    1-312aa
  • 氨基酸序列
    MAAGQNGHEEWVGSAYLFVESSLDKVVLSDAYAHPQQKVAVYRALQAALAESGGSPDVLQMLKIHRSDPQLIVQLRFCGRQPCGRFLRAYREGALRAALQRSLAAALAQHSVPLQLELRAGAERLDALLADEERCLSCILAQQPDRLRDEELAELEDALRNLKCGSGARGGDGEVASAPLQPPVPSLSEVKPPPPPPPAQTFLFQGQPVVNRPLSLKDQQTFARSVGLKWRKVGRSLQRGCRALRDPALDSLAYEYEREGLYEQAFQLLRRFVQAEGRRATLQRLVEALEENELTSLAEDLLGLTDPNGGLA
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    C-terminal 6xHis-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol. If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose, pH 8.0.
  • 復溶:
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4℃ for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Adapter molecule for TNFRSF1A/TNFR1 that specifically associates with the cytoplasmic domain of activated TNFRSF1A/TNFR1 mediating its interaction with FADD. Overexpression of TRADD leads to two major TNF-induced responses, apoptosis and activation of NF-kappa-B. The nuclear form acts as a tumor suppressor by preventing ubiquitination and degradation of isoform p19ARF/ARF of CDKN2A by TRIP12: acts by interacting with TRIP12, leading to disrupt interaction between TRIP12 and isoform p19ARF/ARF of CDKN2A.
  • 基因功能參考文獻:
    1. potential biological significance of TRADD mediated inflammatory response in the development of uterine leiomyoma, is reported. PMID: 28698006
    2. we found that ORF3 protein downregulates TLR3-mediated NF-kappaB signaling via TRADD and RIP1. Our findings provide a new perspective on the cellular response in HEV infection and expand our understanding of the molecular mechanisms of Hepatitis E virus (HEV) pathogenesis in innate immunity. PMID: 27270888
    3. In conclusion, for the first time, we report that TRADD, TRAF2, RIP1 and TAK1 play a role in the regulating TNF-alpha signalling in human myometrium. These findings are of significance given the central role of TNF-alpha in the processes of human labour and delivery. PMID: 28337828
    4. These data for the first time identifies miR-485-5p/TRADD axis in hydrogen sulfide protecting against TNF-alpha-induced neuronal cell apoptosis. PMID: 27562714
    5. By reducing the levels of TRADD, wild type CFTR suppresses downstream proinflammatory NFkappaB signaling. PMID: 27960153
    6. NPM-RAR binding to TRADD selectively inhibits caspase activation, while allowing activation of NFkappaB and JNK PMID: 25791120
    7. The release of extracellular vesicles was triggered by TNFA from BEAS-2b cells.TNFA-triggered extracellular vesicles contained TNFR1 and TRADD. PMID: 26475675
    8. MicroRNA-30c-2-3p negatively regulates NF-kappaB signaling and cell cycle progression through downregulation of TRADD and CCNE1 in breast cancer. PMID: 25732226
    9. domains of calmodulin mediate FADD and TRADD interaction PMID: 25643035
    10. PA induced the apoptosis of HUVECs by initiating the death pathway (TNF-R1/TRADD/caspases 8 pathway), whereas AA enhanced cell survival to protect vascular endothelial cells by activating the survival pathway (TNF-R1/RIP/NF-kappaB 50/NF-kappaB 65). PMID: 25230327
    11. Biologic assessment found that NPM-RAR expression impaired TNF-induced signaling through TRADD, blunting TNF-mediated activation of caspase-3 (CASP3) and caspase-8 (CASP8), to ultimately block apoptosis. PMID: 25033841
    12. TRADD gene expression was knocked down by an antisense oligonucleotide. PMID: 24070137
    13. structure-based mutations of TNFR-1 (P367A and P368A), TRADD (F266A), and RIP1 (M637A and R638A) disrupted formation of the death domain (DD) complex and prevented stable interactions among those DDs PMID: 24361886
    14. Data indicate that the ASK1-FoxO3a-TRADD-caspase 8 pathway is present in neural tube defects (NTDs)-affected tissues. PMID: 23982205
    15. we demonstrated that the association between DR6 and TRADD was enhanced upon DQM3 stimulation and TRADD was involved in DR6-induced signaling activation PMID: 24374337
    16. Data indicate that silencing tumor necrosis factor receptor 1 (TNFR1)-associated death domain protein (TRADD) in glioma cells results in decreased NF-kappaB activity, decreased proliferation of cells, and increased sensitivity to temozolomide. PMID: 23908590
    17. death domains in several proteins, including TRADD, FADD, RIPK1 and TNFR1, were directly inactivated by NleB, an enteropathogenic Escherichia coli (EPEC) type III secretion system effector known to inhibit host nuclear factor-kappaB (NF-kappaB) signalling PMID: 23955153
    18. rpS3 appears to be recruited to the death-inducing signaling complex (DISC) to induce apoptosis by interacting TRADD in response to extracellular stresses. PMID: 22510408
    19. NSP 5a3a induces apoptosis in Head and Neck cell line HN30 through p73-DAXX and TRAF2-TRADD. PMID: 22170762
    20. Death domain SXXE/D motifs are phosphorylated, as is required for stable TNFR1-TRADD complex formation and subsequent activation of NF-kappaB in inflamed mucosa. PMID: 21724995
    21. TRADD contains a nuclear export and import sequence that allows shuttling between the nucleus and the cytoplasm. It induces apoptosis via different mechanisms. PMID: 12045187
    22. chemotherapeutic drugs exhibited their cytotoxic effects in part by down-regulating Akt signaling following TRADD expression PMID: 12446787
    23. Diphtheria toxins induce apoptosis by activating components of the death receptor pathway in a receptor-independent manner. PMID: 12576460
    24. TRADD is involved in the p75(NTR)-mediated antiapoptotic activity of nerve growth factor in breast cancer cells PMID: 12604596
    25. TRAD binds with keratin 14 and has a role in susceptibility of keratinocytes to caspase-8-mediated apoptosis PMID: 14660619
    26. TRADD activates distinct mechanisms of apoptosis from the nucleus and the cytoplasm. PMID: 15761471
    27. TRADD employs a Pelle-like surface to interact with its binding partners, either receptor TNFR1 or adaptor FADD. PMID: 16006552
    28. PAK4 has a role in TNF-alpha induced cell survival pathyways by facilitating TRADD binding to the TNF Receptor PMID: 16227624
    29. TRADD and RIP1 compete for recruitment to the TNFR1 signaling complex and the distinct programs of cell death. PMID: 16611992
    30. These findings suggest that EMAP-II sensitises endothelial cells to apoptosis by facilitating TNF-R1 apoptotic signalling via TRADD mobilization. PMID: 17051333
    31. The expression of TRADD in peripheral blood mononuclear cells was significantly decreased in SLE patients. PMID: 17235653
    32. The structure of TRADD DD was solved by NMR. PMID: 17922260
    33. unique interaction of LMP1 with TRADD encodes the transforming phenotype of viral TRADD signaling and masks TRADD's pro-apoptotic function PMID: 18198944
    34. Mutations in the TRADD gene may contribute to the development of different hematological diseases. PMID: 18661484
    35. glomerular and tubular expression of TNF-alpha, (TNF receptor-associated death domain protein)TRADD, RIP(receptor-interacting protein) and TRAF-2 (TNF receptor-associated factor-) was significantly up-regulated in Lupus nephritis PMID: 19151112

    顯示更多

    收起更多

  • 亞細胞定位:
    Nucleus. Cytoplasm. Cytoplasm, cytoskeleton.
  • 組織特異性:
    Found in all examined tissues.
  • 數(shù)據(jù)庫鏈接:

    HGNC: 12030

    OMIM: 603500

    KEGG: hsa:8717

    STRING: 9606.ENSP00000341268

    UniGene: Hs.460996



主站蜘蛛池模板: 玩弄放荡人妻一区二区三区| 国产成人精品.视频| 欧美人与动欧交视频| 直接观看黄网站免费视频| 最近中文字幕免费大全在线| 国产一本一道久久香蕉| 无码精品国产va在线观看| 久久精品国产99精品国产2021| 欧美一区二区| 亚洲一区无码中文字幕乱码| 女人的天堂a国产在线观看| 国产精品亚洲a∨天堂不卡| 欧美大屁股熟妇bbbbbb| 亚洲精品乱码久久久久久日本| 国产精品爽爽久久久久久竹菊 | 中文字幕乱码一区二区三区免费 | 亚洲欧美日韩成人综合一区| 欧美亚洲色aⅴ大片| 玩弄放荡人妻少妇系列| 亚洲欧美在线观看| 国产免费毛卡片| 国产精品亚洲精品日韩已满| 2018年秋霞无码片| 亚洲伊人久久大香线蕉av| 国产精品久久久久久久久久久久午夜片| 免费看成人欧美片爱潮app| 国产在线高清理伦片a| 亚洲欧洲综合有码无码| 国产肉体xxxx裸体784大胆| 亚洲www啪成人一区二区麻豆| 激情亚洲一区国产精品| 欧美性生交活xxxxxdddd| 动漫无遮挡h纯肉亚洲资源大片| 亚洲午夜成人片| 亚洲妇女无套内射精| 一区二区精品视频日本| 亚洲国产成人久久精品99| 青青草视频在线观看 | 69天堂人成无码免费视频| 人人爽久久久噜噜噜婷婷| 好大好硬好爽免费视频|