在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

  1. 首頁
  2. 蛋白
  3. 重組蛋白
  4. Recombinant Human Transportin-3 (TNPO3 IPO12)

Recombinant Human Transportin-3 (TNPO3 IPO12)

  • 中文名稱：
  • 貨號：
    CSB-YP757558HU
  • 規格：
  • 來源：
    Yeast
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP757558HU
  • 規格：
  • 來源：
    E.coli
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-EP757558HU-B
  • 規格：
  • 來源：
    E.coli
  • 共軛：
    Avi-tag Biotinylated

    E. coli biotin ligase (BirA) is highly specific in covalently attaching biotin to the 15 amino acid AviTag peptide. This recombinant protein was biotinylated in vivo by AviTag-BirA technology, which method is BriA catalyzes amide linkage between the biotin and the specific lysine of the AviTag.

  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-BP757558HU
  • 規格：
  • 來源：
    Baculovirus
  • 其他：
  • 中文名稱：
  • 貨號：
    CSB-MP757558HU
  • 規格：
  • 來源：
    Mammalian cell
  • 其他：

產品詳情

  • 純度：
    >85% (SDS-PAGE)
  • 基因名：
    TNPO3
  • Uniprot No.：
  • 別名：
    Transportin-3; Importin-12; Imp12; Transportin-SR; TRN-SR; TNPO3 IPO12
  • 種屬：
    Homo sapiens (Human)
  • 蛋白標簽：
    Tag?type?will?be?determined?during?the?manufacturing?process.
    The tag type will be determined during production process. If you have specified tag type, please tell us and we will develop the specified tag preferentially.
  • 產品提供形式：
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 復溶：
    We recommend that this vial be briefly centrifuged prior to opening to bring the contents to the bottom. Please reconstitute protein in deionized sterile water to a concentration of 0.1-1.0 mg/mL.We recommend to add 5-50% of glycerol (final concentration) and aliquot for long-term storage at -20℃/-80℃. Our default final concentration of glycerol is 50%. Customers could use it as reference.
  • 儲存條件：
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期：
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期：
    Delivery time may differ from different purchasing way or location, please kindly consult your local distributors for specific delivery time.
    Note: All of our proteins are default shipped with normal blue ice packs, if you request to ship with dry ice, please communicate with us in advance and extra fees will be charged.
  • 注意事項：
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet ：
    Please contact us to get it.

產品評價

靶點詳情

  • 功能：
    Importin, which transports target proteins into the nucleus. Specifically mediates the nuclear import of splicing factor serine/arginine (SR) proteins, such as RBM4, SFRS1 and SFRS2, by recognizing phosphorylated SR domains. Also mediates the nuclear import of serine/arginine (SR) protein CPSF6, independently of CPSF6 phosphorylation. The nuclear import process is regulated by the small GTPase Ran that partitions between cytoplasm and nucleus in the predominantly GDP- and GTP-bound form, respectively. Importin associates with target cargo proteins in the cytoplasm, and the competitive binding of GTP-bound Ran induces the release of cargos in the nucleus.; (Microbial infection) Involved in immunodeficiency virus (HIV-1) infection by importing the pre-integration complex (PIC) into the nucleus. Required for a nuclear maturation step of HIV-1 prior to integration.
  • 基因功能參考文獻：
    1. Combining these results with small-angle X-ray scattering data for the complex of TRN-SR2 with truncated integrase, we propose a molecular model of the complex. We speculate that nuclear import of the PIC may proceed concurrently with the normal nuclear transport. PMID: 28356354
    2. IRF5-TNPO3 genetic variation is associated systemic lupus erythematosus. PMID: 25205108
    3. Data suggest that the HIV-1 integrase (IN)/transportin-SR2 (TRN-SR2) interaction interface is a potential target for antiviral therapy. PMID: 25063804
    4. Tnpo3 mutants that are not able to interact with cleavage and polyadenylation specificity factor 6 do not facilitate HIV-1 infectivity, suggesting a potential route of pharmacological intervention in the treatment of AIDS. PMID: 24449914
    5. TNPO3 mutation is the cause of limb-girdle muscular dystrophy 1F, expands knowledge of the molecular basis of muscular dystrophies and bolsters the importance of defects of nuclear envelope proteins as causes of inherited myopathies. PMID: 23543484
    6. The TNPO3 gene is mapped within the Limb-girdle muscular dystrophy 1F critical interval and its 923-amino acid human gene product is also expressed in skeletal muscle. PMID: 23667635
    7. a model wherein one monomer of TRN-SR2 is bound to one monomer of RanGTP. PMID: 23878195
    8. In skeletal muscle of limb-girdle muscular dystrophy 1F individuals, expression of transportin 3 indicates altered transportin 3 function. PMID: 23543484
    9. These results suggest that TNPO3 and cyclophilin A facilitate HIV-1 infection by coordinating proper uncoating of the core in target cells. PMID: 23097435
    10. Identification of residues in the C-terminal domain of HIV-1 integrase that mediate binding to the transportin-SR2 protein. PMID: 22872638
    11. TNPO3 can directly engage the HIV-1 IN tetramer prebound to the cognate DNA. PMID: 22872640
    12. Transportin 3 and importin alpha act as receptors and are required for effective nuclear import of HIV-1 integrase in virus-infected cells. PMID: 21326825
    13. TNPO3 interacts with HIV-1 gag in the cytoplasm to assist HIV-1 infection after nuclear import. PMID: 22398280
    14. TNPO3 promotes HIV-1 infectivity at a step in the virus life cycle that is detectable after the preintegration complex arrives in the nucleus and capsid is the viral determinant for TNPO3 dependence. PMID: 22145813
    15. TNPO3 binds to a surface of monomeric HIV-1 integrase that remains exposed after tetramerization. PMID: 22176773
    16. a novel nuclear localization signal and mechanism for serpinF1 nuclear import PMID: 22028839
    17. The authors demonstrated that TNPO3 was required by several lentiviruses for nuclear import. PMID: 21976643
    18. Tnp3 binds to tRNAs and capsids proteins, and is required for efficient HIV-1 integration. PMID: 21901095
    19. Here the authors discover a link between the viral entry of HIV and its interaction with TRN-SR2. PMID: 21276267
    20. capsid, not integrase, is the dominant viral factor that dictates transportin 3 dependency during HIV-1 infection PMID: 19846519
    21. Results imply that the mechanism by which SR proteins are imported to the nucleus is conserved between Drosophila and humans and involves the nuclear import receptor transportin-SR PMID: 12134081

    顯示更多

    收起更多

  • 相關疾病：
    Limb-girdle muscular dystrophy 1F (LGMD1F)
  • 亞細胞定位：
    Nucleus envelope. Cytoplasm.
  • 組織特異性：
    Expressed in skeletal muscle.
  • 數據庫鏈接：

    HGNC: 17103

    OMIM: 608423

    KEGG: hsa:23534

    STRING: 9606.ENSP00000265388

    UniGene: Hs.193613



主站蜘蛛池模板： 亚洲精品久久久久久一区二区| 免费无码又爽又刺激高潮的动态图| 亚洲国产成人精品无码区在线软件| 亚洲精品无码久久久久av麻豆| 国产亚洲精品久久无码98| 丰满熟妇被猛烈进入高清片| 亚洲一区二区三区写真| 国产精品高潮呻吟av久久4虎| 人妻少妇精品专区性色av| 动漫成人无码精品一区二区三区| 欲色欲色天天天www| 农民人伦一区二区三区| 日本护士╳╳╳hd少妇| 国产精品综合一区二区三区| 亚洲国产成人高清影视| 久久精品人妻无码专区| 亚洲日韩aⅴ在线视频| 少妇性l交大片| 成年奭片免费观看视频天天看| 中本亚洲欧美国产日韩| 国产毛片久久久久久国产毛片| 最近在线更新8中文字幕免费| 午夜爽爽爽男女污污污网站| 国产成人精品自在线拍| 国产日韩在线时看高清视频 | 久久久国产精品人人片| 久久99国产亚洲高清观看首页| 长腿校花无力呻吟娇喘| 狠狠色老熟妇老熟女| 无码喷水一区二区浪潮av| 激情内射日本一区二区三区| 人妻在客厅被c的呻吟| 在线天堂资源www在线污| 国产精品久久久久久久久久直播 | 国产日产亚洲系列最新美使用方法| 老熟女老太婆爽| 国产午夜精品av一区二区 | 久久精品国产精品亚洲| 国产成人一区二区三区在线观看| 国产按头口爆吞精在线视频| 破了亲妺妺的处免费视频国产|