在线日韩日本国产亚洲丨少妇伦子伦情品无吗丨欧美性猛交xxxx免费看蜜桃丨精品人妻系列无码一区二区三区丨亚洲精品无码不卡在线播放

Your Good Partner in Biology Research

Recombinant Human Transmembrane prolyl 4-hydroxylase (P4HTM), partial

In Stock
  • 中文名稱:
    人P4HTM重組蛋白
  • 貨號:
    CSB-EP878913HU
  • 規格:
    ¥1344
  • 圖片:
    • (Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
  • 其他:

產品詳情

  • 純度:
    Greater than 90% as determined by SDS-PAGE.
  • 基因名:
    P4HTM
  • Uniprot No.:
  • 別名:
    EGLN4; HIF PH4; HIF Prolyl Hydroxylase 4; HIF prolyl hydroxylase PH 4; HIF prolyl hydroxylase PH4; HIF-PH4; HIF-prolyl hydroxylase 4; HIFPH4; HPH 4; HPH-4; Hypoxia inducible factor prolyl 4 hydroxylase; Hypoxia-inducible factor prolyl hydroxylase 4; P4H with transmembrane domain; P4H-TM; P4htm; P4HTM_HUMAN; PH 4; PH4; PHD 4; Proline 4 hydroxylase; prolyl 4-hydroxylase ; Transmembrane prolyl 4-hydroxylase
  • 種屬:
    Homo sapiens (Human)
  • 蛋白長度:
    Partial of Isoform 3
  • 來源:
    E.coli
  • 分子量:
    70.5kDa
  • 表達區域:
    82-563aa
  • 氨基酸序列
    VHYSNGDESSDPGPQHRAQGPGPEPTLGPLTRLEGIKVGHERKVQLVTDRDHFIRTLSLKPLLFEIPGFLTDEECRLIIHLAQMKGLQRSQILPTEEYEEAMSTMQVSQLDLFRLLDQNRDGHLQLREVLAQTRLGNGWWMTPESIQEMYAAIKADPDGDGVLSLQEFSNMDLRDFHKYMRSHKAESSELVRNSHHTWLYQGEGAHHIMRAIRQRVLRLTRLSPEIVELSEPLQVVRYGEGGHYHAHVDSGPVYPETICSHTKLVANESVPFETSCRQVSPNWGLPSILRPGTPMTQAQPCTVGVPLGMGPGDHWVIPVSPWEHPQLGTCSVPPLPYSYMTVLFYLNNVTGGGETVFPVADNRTYDEMSLIQDDVDLRDTRRHCDKGNLRVKPQQGTAVFWYNYLPDGQGWVGDVDDYSLHGGCLVTRGTKWIANNWINVDPSRARQALFQQEMARLAREGGTDSQPEWALDRAYRDARVEL
    Note: The complete sequence may include tag sequence, target protein sequence, linker sequence and extra sequence that is translated with the protein sequence for the purpose(s) of secretion, stability, solubility, etc.
    If the exact amino acid sequence of this recombinant protein is critical to your application, please explicitly request the full and complete sequence of this protein before ordering.
  • 蛋白標簽:
    N-terminal 6xHis-SUMO-tagged
  • 產品提供形式:
    Liquid or Lyophilized powder
    Note: We will preferentially ship the format that we have in stock, however, if you have any special requirement for the format, please remark your requirement when placing the order, we will prepare according to your demand.
  • 緩沖液:
    If the delivery form is liquid, the default storage buffer is Tris/PBS-based buffer, 5%-50% glycerol.
    Note: If you have any special requirement for the glycerol content, please remark when you place the order.
    If the delivery form is lyophilized powder, the buffer before lyophilization is Tris/PBS-based buffer, 6% Trehalose.
  • 儲存條件:
    Store at -20°C/-80°C upon receipt, aliquoting is necessary for mutiple use. Avoid repeated freeze-thaw cycles.
  • 保質期:
    The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself.
    Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
  • 貨期:
    3-7 business days
  • 注意事項:
    Repeated freezing and thawing is not recommended. Store working aliquots at 4°C for up to one week.
  • Datasheet & COA:
    Please contact us to get it.

產品評價

靶點詳情

  • 功能:
    Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex.
  • 基因功能參考文獻:
    1. The results suggest that SESN2 increases degradation of HIF-1A via AMPK-PHD regulation that contributes to inhibition of in vitro and in vivo tumorigenesis. PMID: 27840318
    2. This review will expand our knowledge of biology of HIFs, PHDs, PHD inhibitors, and bone regeneration, and it may also aid the design of novel therapies for accelerating bone repair and regeneration or inhibiting bone tumours. [review] PMID: 24895555
    3. Results suggest that increased expression of prolyl hydroxylase (PH) might play an role in the physiology of uterine leiomyoma during the menstrual cycle. PMID: 23241241
    4. Data suggest that PH-4 is a novel hypoxia-inducible factor-prolyl hydroxylase that may be involved in the degradation of hypoxia-inducible transcription factors under normoxia. PMID: 12163023
    5. the longest and shortest isoenzymes have major transcripts encoding inactive polypeptides, which suggest novel regulation by alternative splicing. PMID: 12788921
    6. crystal structure of the peptide-substrate-binding domain PMID: 15456751
    7. This review summarizes recent progress in elucidating the molecular mechanisms of hypoxia-inducible factor (HIF)-1 activation, focusing on the role of oxygen-dependent asparaginyl hydroxylase in hypoxia signal transduction. PMID: 16154531

    顯示更多

    收起更多

  • 亞細胞定位:
    Endoplasmic reticulum membrane; Single-pass type II membrane protein.
  • 組織特異性:
    Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts.
  • 數據庫鏈接:

    HGNC: 28858

    OMIM: 614584

    KEGG: hsa:54681

    STRING: 9606.ENSP00000341422

    UniGene: Hs.654944



主站蜘蛛池模板: 国产影片av级毛片特别刺激| 成人无码免费一区二区三区| 国产中文欧美日韩在线| 精品无码av无码专区| 日本一卡2卡三卡4卡免费网站| 人人超碰人人超级碰国| 暖暖视频日本| 国产精品亚洲专区无码不卡| 中文字幕熟妇人妻在线视频| 久久久久国色av∨免费看| 日本少妇春药特殊按摩3| 中文天堂网www新版资源在线| 卡一卡二卡三免费视频| 亚洲成av人片无码bt种子下载| 少妇被又大又粗猛烈进出视频| 亚洲精品乱码久久久久久按摩| 天天躁日日躁狠狠躁欧美老妇小说| 国产亚洲精品97在线视频一| 少妇人妻中文字幕hd| 色诱久久久久综合网ywww| 精品人妻av区乱码| 亚洲妇女水蜜桃av网网站| 男女做爰猛烈啪啪吃奶动 | 国产亚洲精品久久一区二区| 国产欧美一区二区精品久久久| 98国产精品综合一区二区三区| 亚洲国产精品一区二区动图| 国产av综合第一页| 天美传媒一区二区| 少妇内射兰兰久久| 720lu国产刺激无码| 亚洲人成人网站在线观看| 亚洲成av人片在线观看| 久久精品99av高久久精品 | 一边添奶一边添p好爽视频 | 97久久香蕉国产线看观看| 新区乱码无人区二精东| 亚洲欧洲美洲在线观看| 国产美女精品一区二区三区 | 国产精品自在拍一区二区不卡 | 人人爽人人爽人人爽|